Abstract
A wide array of options are now available for migraine prophylaxis. Conventional treatments include beta-blockers, anticonvulsants, antidepressants, calcium antagonists and antiserotoninergic drugs. Emerging medications such as ACE inhibitors, sartans and nutritional supplements are gaining favour for migraine prophylaxis. Botulinum toxin type A is a promising therapeutic tool for chronic migraine. Tonabersat is likely to be a step forward for the treatment of migraine with aura. However, much work is needed to identify predictive clinical features of successful responsiveness and to better define the duration of prophylaxis.
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References
Rasmussen BK (1995) Epidemiology of headache. Cephalalgia 15:45–68
Schoenen J (2006) Neurophysiological features of the migrainous brain. Neurol Sci 27(2):77–81
Olesen J, Burstein R, Ashina M, Tfelt-Hansen P (2009) Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol 8:679–690
Lipton RB, Stewart WF, Diamond S et al (2001) Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 41:646–657
Lipton RB, Bigal ME, Diamond M et al (2007) Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68:343–349
Schmitz N, Admiraal-Behloul F, Arkink EB et al (2008) Attack frequency and disease duration as indicators for brain damage in migraine. Headache 48(7):1044–1055
Vikelis M, Rapoport AM (2010) Role of antiepileptic drugs as preventive agents for migraine. CNS Drugs 24(1):21–33
Chronicle E, Mulleners W (2004) Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev 3: CD003226
Pringsheim T, Davenport WJ, Becker WJ (2010) Prophylaxis of migraine headache. CMAJ 182(7):E269–E276
Wyszynski DF, Nambisan M, Surve T et al (2005) Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 64(6):961–965
Mathew NT, Rapoport A, Saper J et al (2001) Efficacy of gabapentin in migraine prophylaxis. Headache 41:119–128
Galletti F, Cupini LM, Corbelli I et al (2009) Pathophysiological basis of migraine prophylaxis. Prog Neurobiol 89(2):176–192
Linde K, Rossnagel K (2004) Propranolol for migraine prophylaxis. Cochrane Database Syst Rev 2: CD003225
Jackson JL, Shimeall W, Sessums L et al (2010) Tricyclic antidepressants and headaches: systematic review and meta-analysis. BMJ 341: c5222. doi:10.1136/bmj.c5222
Ozyalcin SN, Talu GK, Kiziltan E et al (2005) The efficacy and safety of venlafaxine in the prophylaxis of migraine. Headache 45(2):144–152
Osterman PO (1977) A comparison between placebo, pizotifen and 1-isopropyl-3-hydroxy-5-semicarbazono-6-oxo-2.3.5.6-tetrahydroindol (Divascan) in migraine prophylaxis. Acta Neurol Scand 56(1):17–28
Silberstein SD (1998) Methysergide. Cephalalgia 18(7):421–435
Reveiz-Herault L, Cardona AF, Ospina EG, Carrillo P (2003) Effectiveness of flunarizine in the prophylaxis of migraine: a meta-analytical review of the literature. Rev Neurol 36(10):907–912
Diener HC, Gendolla A, Feuersenger A et al (2009) Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial. Cephalalgia 29(9):921–927
Tronvik E, Stovner LJ, Bovim G et al (2008) Angiotensin-converting enzyme gene insertion/deletion polymorphism in migraine patients. BMC Neurol 8: 4
Schuh-hofer S, Flach U, Meisel A et al (2007) Efficacy of lisinopril in migraine prophylaxis–an open label study. Eur J Neurol 14(6):701–703
Schoenen J, Jacquy J, Lenaerts M (1998) Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial. Neurology 50:466–470
Sándor P, Di Clemente L, Coppola G et al (2005) Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized, controlled trial. Neurology 64:713–715
Peikert A, Wilimzig C, Kohne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multicentre, placebo-controlled and double blind randomized study. Cephalalgia 16:257–263
Diener HC, Rahlfs VW, Danesch U (2004) The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51:89–97
Pittler MH, Ernst E (2004) Feverfew for preventing migraine. Cochrane Database Syst Rev (1):CD002286
Shuhendler AJ, Lee S, Siu M et al (2009) Efficacy of botulinum toxin type A for the prophylaxis of episodic migraine headaches: a meta-analysis of randomized, double-blind, placebo-controlled trials. Pharmacotherapy 29(7):784–789
Aurora SK, Dodick DW, Turkel CC et al (2010) OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia 30(7):793–803
Diener HC, Dodick DW, Aurora SK et al (2010) OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia 30(7):804–814
Dodick DW, Turkel CC, DeGryse RE et al (2010) OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache 50(6):921–936
Hauge AW, Asghar MS, Schytz HW et al (2009) Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study. Lancet Neurol 8(8):718–723
Pringsheim T, Davenport WJ, Dodick D (2008) Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology 70(17):1555–1563
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Barbanti, P., Aurilia, C., Egeo, G. et al. Migraine prophylaxis: what is new and what we need?. Neurol Sci 32 (Suppl 1), 111–115 (2011). https://doi.org/10.1007/s10072-011-0526-3
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DOI: https://doi.org/10.1007/s10072-011-0526-3