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Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

  • Neuropathic Pain (E Eisenberg, Section Editor)
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Abstract

Psychophysical evaluation of endogenous pain inhibition via conditioned pain modulation (CPM) represents a new generation of laboratory tests for pain assessment. In this review we discuss recent findings on CPM in neuropathic pain and refer to psychophysical, neurophysiological, and methodological aspects of its clinical implications. Typically, chronic neuropathic pain patients express less efficient CPM, to the extent that incidence of acquiring neuropathic pain (e.g. post-surgery) and its intensity can be predicted by a pre-surgery CPM assessment. Moreover, pre-treatment CPM evaluation may assist in the correct choice of serotonin-noradrenalin reuptake inhibitor analgesic agents for individual patients. Evaluation of pain modulation capabilities can serve as a step forward in individualizing pain medicine.

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Conflict of Interest

Dr Yelena Granovsky is a paid consultant of Medoc Ltd. Dr Granovsky reports receiving a grant from the Israeli Scientific Foundation (ISF #147/08) and an IIT grant from Eli Lilly Inc.

Human and Animal Rights and Informed Consent

With regard to the author’s research cited in this paper, all institutional and national guidelines for the care and use of humans and laboratory animals were followed. In addition, all procedures were followed in accordance with the ethical standards of the responsible local committee of Rambam Health Care Campus, Haifa, Israel.

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  1. Department of Neurology, Rambam Health Care Campus, Laboratory of Clinical Neurophysiology, Faculty of Medicine, Technion, PO Box 9602, Haifa, Israel

    Yelena Granovsky

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This article is part of the Topical Collection on Neuropathic Pain

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Granovsky, Y. Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain. Curr Pain Headache Rep 17, 361 (2013). https://doi.org/10.1007/s11916-013-0361-8

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