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Bone Imaging and Fracture Risk after Spinal Cord Injury

  • Therapeutics and Medical Management (E Shane and R Adler, Section Editors)
  • Published:
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Abstract

Spinal cord injury (SCI) is characterized by marked bone loss and an increased risk of fracture with high complication rate. Recent research based on advanced imaging analysis, including quantitative computed tomography (QCT) and patient-specific finite element (FE) modeling, has provided new and important insights into the magnitude and temporal pattern of bone loss, as well as the associated changes to bone structure and strength, following SCI. This work has illustrated the importance of early therapeutic treatment to prevent bone loss after SCI and may someday serve as the basis for a clinical fracture risk assessment tool for the SCI population. This review provides an update on the epidemiology of fracture after SCI and discusses new findings and significant developments related to bone loss and fracture risk assessment in the SCI population based on QCT analysis and patient-specific FE modeling.

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Conflict of Interest

Dr. Edwards declare they have no conflicts of interest to disclose

Dr. Schnitzer reports non-financial support from Eli LIlly, non-financial support from Novartis, outside the submitted work.

Human and Animal Rights and Informed Consent

All studies by Dr. Edwards and Dr. Schnitzer involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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  1. Human Performance Laboratory, Faculty of Kinesiology, and Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, 2500 University Dr. NW, Calgary, AB, T2N 1N4, Canada

    W. Brent Edwards

  2. Department of Physical Medicine and Rehabilitation, and Department of Internal Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL, 60611, USA

    Thomas J. Schnitzer

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  1. W. Brent Edwards
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Correspondence to W. Brent Edwards.

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Edwards, W.B., Schnitzer, T.J. Bone Imaging and Fracture Risk after Spinal Cord Injury. Curr Osteoporos Rep 13, 310–317 (2015). https://doi.org/10.1007/s11914-015-0288-6

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