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Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?

  • Hypertension and Obesity (E Reisin, Section Editor)
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Abstract

Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events. Hyperuricemia has been attributed to hyperinsulinemia in metabolic syndrome and to decreased uric acid excretion in kidney dysfunction, and is not acknowledged as a main mediator of metabolic syndrome, renal disease, and cardiovascular disorder development. However, more recent investigations have altered this traditional view and shown, by providing compelling evidence, to support an independent link between hyperuricemia and increased risk of metabolic syndrome, diabetes, hypertension, kidney disease and cardiovascular disorders. However, despite these new findings, controversy regarding the exact role of uric acid in inducing these diseases remains to be unfolded. Furthermore, recent data suggest that the high-fructose diet in the United State, as a major cause of hyperuricemia, may be contributing to the metabolic syndrome/obesity epidemic, diabetes, hypertension, kidney disease and cardiovascular disorder. Our focus in this review is to discuss the available evidence supporting a role for uric acid in the development of metabolic syndrome, hypertension, renal disease, and cardiovascular disorder; and the potential pathophysiology mechanisms involved.

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Acknowledgment

This work was supported by National Institutes of Health grants 8P20 GM103514 and P20 RR018766 (to Z. Soltani and D.R. Kapusta) and American Heart Association grant 12GRNT12060613 (to D.R. Kapusta).

Conflict of Interest

Z. Soltani declares that he has no conflict of interest.

Kashef Rasheed declares that he has no conflict of interest.

D.R. Kapusta declares that he has no conflict of interest.

E. Reisin declares that he has no conflict of interest.

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  1. Section of Nephrology and Hypertension, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, Room 330A, New Orleans, LA, 70112, USA

    Zohreh Soltani, Kashaf Rasheed & Efrain Reisin

  2. Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Daniel R. Kapusta

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  1. Zohreh Soltani
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Soltani, Z., Rasheed, K., Kapusta, D.R. et al. Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?. Curr Hypertens Rep 15, 175–181 (2013). https://doi.org/10.1007/s11906-013-0344-5

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