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Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension

  • Hypertension and Metabolic Syndrome (J Sperati, Section Editor)
  • Published:
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Abstract

Purpose of the Review

Our review explores the epidemiology, physiology, and clinical data surrounding the connection between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension.

Recent Findings

Compelling physiologic mechanisms have been proposed to explain a causal relationship between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension but clinical studies have given mixed results in terms of whether intervening with hyperuricemia using urate-lowering therapy has any beneficial effects for patients with these conditions.

Summary

Despite the large amount of research already put into this topic, more randomized placebo-controlled trials are needed to more firmly establish whether a cause-effect relationship exists and whether lowering uric acid levels in patients with these conditions is beneficial.

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Availability of Data and Materials

No raw data or materials were used for this literature review.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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  1. Section of Nephrology and Hypertension, Louisiana State University Health Science Center, New Orleans, LA, USA

    Ramzi Vareldzis, Annalisa Perez & Efrain Reisin

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R.V., A.P., and E.R. wrote the main manuscript text, and all three authors also reviewed the final manuscript

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Vareldzis, R., Perez, A. & Reisin, E. Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension. Curr Hypertens Rep (2024). https://doi.org/10.1007/s11906-024-01295-3

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