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Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic

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Abstract

The success of potent combination antiretroviral therapy (ART) for HIV infection is compromised primarily by failure to maintain optimal levels of adherence over the long term. Recent reviews suggest behavioral interventions to promote ART adherence can have significant effects, but these tend to be small and to diminish over time; sustained improvements in biomarkers are particularly elusive. In this article, we update current reviews, focusing specifically on the 13 studies evaluating behavioral interventions to promote ART adherence published since September 2007. We describe the range of intervention strategies employed and qualitatively summarize findings of their efficacy. In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment.

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Disclosure

No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Department of Psychology, University of Washington, Campus Box 351525, Seattle, WA, 98195-1525, USA

    Jane M. Simoni

  2. Center for Health, Intervention & Prevention, University of Connecticut, 2006 Hillside Road, Storrs, CT, 06269, USA

    K. Rivet Amico

  3. Center for Health, Intervention & Prevention, Department of Psychology, University of Connecticut, 2006 Hillside Road, Unit 1248, Storrs, CT, 06269, USA

    Laramie Smith

  4. Department of Psychology, University of Washington, Campus Box 351525, Seattle, WA, 98195-1525, USA

    Kimberly Nelson

Authors
  1. Jane M. Simoni
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  2. K. Rivet Amico
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  3. Laramie Smith
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  4. Kimberly Nelson
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Correspondence to Jane M. Simoni.

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Simoni, J.M., Amico, K.R., Smith, L. et al. Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic. Curr HIV/AIDS Rep 7, 44–51 (2010). https://doi.org/10.1007/s11904-009-0037-5

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  • DOI: https://doi.org/10.1007/s11904-009-0037-5

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