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100% Adherence Study: Educational Workshops vs. Video Sessions to Improve Adherence Among ART-Naïve Patients in Salvador, Brazil

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Abstract

We conducted a randomized trial to test an intervention aimed at increasing adherence to antiretroviral therapy (ART) among HIV-positive, ART-naïve patients in Salvador, Brazil. Participants (N = 107) were randomized to either educational workshops based on the information-motivation-behavioral skills model (n = 52) or a control video session (n = 55). Changes in self-reported ART adherence, viral load, CD4 cell counts and ART pharmacy records were measured periodically over 12 months. After 3–6 months, ART adherence (≥95%) was 77.8% in the workshop group and 85.7% in video group (as treated) and 53.8% and 65.5%, respectively, using intention-to-treat (ITT) analysis (both P > 0.05) At 9–12 months, ART adherence decreased to 73.7% in the workshop group and 79.1% in the video group (as treated) and 53.8% and 61.8% using ITT, respectively. No differences were found in self-reported adherence, viral load or pharmacy records between groups. We found that the educational workshop intervention does not increase adherence to ART.

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Acknowledgements

We wish to thank all the respondents who gave their valuable time to participate in this study. We also are indebted to the research team and staff from the Reference Center for AIDS Treatment (CREAIDS) in Salvador-Brazil for logistic support. This research was supported by a grant from the Brazilian National AIDS Program, Ministry of Health. We also would like to thank the University of California, San Francisco, Center for AIDS Prevention Studies (NIMH-P30 MH062246), the International Clinical, Operational and Health Services Research Training Award (ICOHRTA), Brazil Scientists Program, Fogarty International Center (D43TW005799) and the Starr Foundation AIDS International Scholarship Fund for their technical assistance and support during the writing of this paper. Dr. Bangsberg was supported by K24 AA015287.

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Authors and Affiliations

  1. Federal University of Bahia, Salvador, Bahia, Brazil

    Marcia Sampaio-Sa, Eduardo M. Netto & Carlos Brites

  2. Secretariat of Health of the State of Bahia, Salvador, Bahia, Brazil

    Marcia Sampaio-Sa, Maria de Lourdes Dourado & Celia Teixeira

  3. University of California, San Francisco, CA, USA

    Kimberly Page-Shafer & Jennifer Evans

  4. University of California, San Francisco, San Francisco General Hospital, California (UCSF-SFGH), San Francisco, CA, USA

    David R. Bangsberg

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  1. Marcia Sampaio-Sa
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Correspondence to Marcia Sampaio-Sa.

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Sampaio-Sa, M., Page-Shafer, K., Bangsberg, D.R. et al. 100% Adherence Study: Educational Workshops vs. Video Sessions to Improve Adherence Among ART-Naïve Patients in Salvador, Brazil. AIDS Behav 12 (Suppl 1), 54–62 (2008). https://doi.org/10.1007/s10461-008-9414-0

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