Skip to main content
Log in

Salvage Options for Fundoplication Failure

  • Esophagus (J Clarke and N Ahuja, Section Editors)
  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Gastroesophageal reflux disease (GERD) affects millions of people worldwide. Many patients with medically refractory symptoms ultimately undergo antireflux surgery, most often with a laparoscopic fundoplication. Symptoms related to GERD may persist or recur. Revisional surgery is necessary in some patients.

Recent Findings

A reoperative fundoplication is the most commonly performed salvage procedure for failed fundoplication. Although redo fundoplication has been reported to have increased risk of morbidity compared with primary cases, increasing experience with the minimally invasive approach to reoperative surgery has significantly improved patient outcome with acceptable resolution of reflux symptoms in the majority of patients.

Summary

Recurrence of reflux symptoms after an initial fundoplication requires a thorough work-up and a thoughtful approach. While reoperative fundoplication is the most common procedure performed, there are other options and the treatment should be tailored to the patient, their history, and the mechanism of fundoplication failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Richter JE, Rubenstein JH. Presentation and epidemiology of gastroesophageal reflux disease. Gastroenterology. 2018;154(2):267–76.

    Article  Google Scholar 

  2. Rubenstein JH, Chen JW. Epidemiology of gastroesophageal reflux disease. Gastroenterol Clin N Am. 2014;43(1):1–14. https://doi.org/10.1016/j.gtc.2013.11.006.

    Article  Google Scholar 

  3. Furnée EJB, Draaisma WA, Broeders IAMJ, Gooszen HG. Surgical reintervention after failed antireflux surgery: a systematic review of the literature. J Gastrointest Surg. 2009;13(8):1539–49.

    Article  Google Scholar 

  4. Grover BT, Kothari SN. Reoperative antireflux surgery. Surg Clin North Am. 2015;95(3):629–40. https://doi.org/10.1016/j.suc.2015.02.014.

    Article  PubMed  Google Scholar 

  5. van Beek DB, Auyang ED, Soper NJ. A comprehensive review of laparoscopic redo fundoplication. Surg Endosc. 2011;25(3):706–12.

    Article  Google Scholar 

  6. Khan F, Maradey-Romero C, Ganocy S, Frazier R, Fass R. Utilisation of surgical fundoplication for patients with gastro-oesophageal reflux disease in the USA has declined rapidly between 2009 and 2013. Aliment Pharmacol Ther. 2016;43(11):1124–31.

    Article  CAS  Google Scholar 

  7. Finlayson SRG, Birkmeyer JD, Laycock WS. Trends in surgery for gastroesophageal reflux disease: the effect of laparoscopic surgery on utilization. Surgery. 2003;133(2):147–53.

    Article  Google Scholar 

  8. Robinson B, Dunst CM, Cassera MA, Reavis KM, Sharata A, Swanstrom LL. 20 years later: laparoscopic fundoplication durability. Surg Endosc. 2015;29(9):2520–4. https://doi.org/10.1007/s00464-014-4012-x.

    Article  PubMed  Google Scholar 

  9. Morgenthal CB, Shane MD, Stival A, Gletsu N, Milam G, Swafford V, et al. The durability of laparoscopic Nissen fundoplication: 11-year outcomes. J Gastrointest Surg. 2007;11(6):693–700.

    Article  Google Scholar 

  10. Broeders JA, Rijnhart-de Jong HG, Draaisma WA, Bredenoord AJ, Smout AJ, Gooszen HG. Ten-year outcome of laparoscopic and conventional Nissen fundoplication. Ann Surg. 2009;250(5):698–706.

    Article  Google Scholar 

  11. Kellokumpu I, Voutilainen M, Haglund C, Färkkilä M, Roberts PJ, Kautiainen H. Quality of life following laparoscopic Nissen fundoplication: assessing short-term and long-term outcomes. World J Gastroenterol. 2013;19(24):3810–8.

    Article  Google Scholar 

  12. Kelly JJ, Watson DI, Chin KF, Devitt PG, Game PA, Jamieson GG. Laparoscopic Nissen fundoplication: clinical outcomes at 10 years. J Am Coll Surg. 2007;205(4):570–5.

    Article  Google Scholar 

  13. Dallemagne B, Weerts J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, et al. Clinical results of laparoscopic fundoplication at ten years after surgery. Surg Endosc Other Interv Tech. 2006;20(1):159–65.

    Article  CAS  Google Scholar 

  14. Oelschlager BK, Ma KC, Soares RV, Montenovo MI, Munoz Oca JE, Pellegrini CA. A broad assessment of clinical outcomes after laparoscopic antireflux surgery. Ann Surg. 2012;256(1):87–94.

    Article  Google Scholar 

  15. Smith CD, McClusky DA, Rajad MA, Lederman AB, Hunter JG, Richards WO, et al. When fundoplication fails: redo? Ann Surg. 2005;241(6):861–71.

    Article  Google Scholar 

  16. Al Hashmi AW, Pineton de Chambrun G, Souche R, Bertrand M, De Blasi V, Jacques E, et al. A retrospective multicenter analysis on redo-laparoscopic anti-reflux surgery: conservative or conversion fundoplication? Surg Endosc. 2019;33(1):243–51.

    Article  Google Scholar 

  17. • Obeid NR, Altieri MS, Yang J, Park J, Price K, Bates A, et al. Patterns of reoperation after failed fundoplication: an analysis of 9462 patients. Surg Endosc. 2018;32(1):345–50. This analysis examines the incidence and pattern of fundoplication failure in a statewide database. Fundoplication had a low failure rate and redo fundoplication is more commonly performed and at an earlier point than conversion to gastric bypass.

    Article  Google Scholar 

  18. Vilar A, Priego P, Puerta A, Cuadrado M, García Angarita F, García-Moreno F, et al. Redo surgery after failure of antireflux surgery. Am Surg. 2018;84(11):1819–24.

    PubMed  Google Scholar 

  19. Antiporda M, Jackson C, Smith CD, Thomas M, Elli EF, Bowers SP. Strategies for surgical remediation of the multi-fundoplication failure patient. Surg Endosc Other Interv Tech. 2018;33:1474–81. https://doi.org/10.1007/s00464-018-6429-0.

    Article  Google Scholar 

  20. Khajanchee YS. Laparoscopic reintervention for failed antireflux surgery. Arch Surg. 2007;142(8):785.

    Article  Google Scholar 

  21. Makdisi G, Nichols FC, Cassivi SD, Wigle DA, Shen KR, Allen MS, et al. Laparoscopic repair for failed antireflux procedures. Ann Thorac Surg. 2014;98(4):1261–6. https://doi.org/10.1016/j.athoracsur.2014.05.036.

    Article  PubMed  Google Scholar 

  22. Wakeam E, Wee J, Lebenthal A, Ali SO, Gilbert RJ, Bueno R. Does BMI predict recurrence or complications after reoperative reflux surgery? Review of a single center’s experience and a comparison of outcomes. J Gastrointest Surg. 2014;18(11):1965–73.

    Article  CAS  Google Scholar 

  23. Pennathur A, Awais O, Luketich JD. Minimally invasive redo antireflux surgery: lessons learned. Ann Thorac Surg. 2010;89(6):S2174–9. https://doi.org/10.1016/j.athoracsur.2010.03.077.

    Article  PubMed  Google Scholar 

  24. Suppiah A, Sirimanna P, Vivian SJ, O’Donnell H, Lee G, Falk GL. Temporal patterns of hiatus hernia recurrence and hiatal failure: quality of life and recurrence after revision surgery. Dis Esophagus. 2017;30(4):1–8.

    Article  CAS  Google Scholar 

  25. Morgenthal CB, Lin E, Shane MD, Hunter JG, Smith CD. Who will fail laparoscopic Nissen fundoplication? Preoperative prediction of long-term outcomes. Surg Endosc Other Interv Tech. 2007;21(11):1978–84.

    Article  Google Scholar 

  26. Power C, Maguire D, McAnena O. Factors contributing to failure of laparoscopic Nissen fundoplication and the predictive value of preoperative assessment. Am J Surg. 2004;187(4):457–63.

    Article  Google Scholar 

  27. Davis CS, Baldea A, Johns JR, Joehl RJ, Fisichella PM. The evolution and long-term results of laparoscopic antireflux surgery for the treatment of gastroesophageal reflux disease. JSLS J Soc Laparoendosc Surg. 2010;14(3):332–41.

    Article  CAS  Google Scholar 

  28. Perez AR, Moncure AC, Rattner DW. Obesity adversely affects the outcome of antireflux operations. Surg Endosc. 2004;15(9):986–9.

    Article  Google Scholar 

  29. Tekin K, Toydemir T, Yerdel MA. Is laparoscopic antireflux surgery safe and effective in obese patients? Surg Endosc. 2012;26(1):86–95.

    Article  Google Scholar 

  30. Tandon A, Rao R, Hotouras A, Nunes QM, Hartley M, Gunasekera R, et al. Safety and effectiveness of antireflux surgery in obese patients. Ann R Coll Surg Engl. 2017;99(7):515–23.

    Article  CAS  Google Scholar 

  31. Akimoto S, Nandipati KC, Kapoor H, Yamamoto SR, Pallati PK, Mittal SK. Association of body mass index (BMI) with patterns of fundoplication failure: insights gained. J Gastrointest Surg. 2015;19(11):1943–8.

    Article  Google Scholar 

  32. Page MP, Kastenmeier A, Goldblatt M, Frelich M, Bosler M, Wallace J, et al. Medically refractory gastroesophageal reflux disease in the obese: what is the best surgical approach? Surg Endosc. 2014;28(5):1500–4.

    Article  Google Scholar 

  33. Kim M, Navarro F, Eruchalu CN, Augenstein VA, Heniford BT, Stefanidis D. Minimally invasive Roux-en-Y gastric bypass for fundoplication failure offers excellent gastroesophageal reflux control. Am Surg. 2014;80(7):696–703.

    PubMed  Google Scholar 

  34. Lamb PJ, Myers JC, Jamieson GG, Thompson SK, Devitt PG, Watson DI. Long-term outcomes of revisional surgery following laparoscopic fundoplication. Br J Surg. 2009;96:391–7.

    Article  CAS  Google Scholar 

  35. •• Patti MG, Allaix ME, Fisichella PM. Analysis of the causes of failed antireflux surgery and the principles of treatment a review. JAMA Surg. 2015;150(6):585–90. This review is a thorough report on the causes of fundoplication failure and the appropriate evaluation needed to determine the optimal treatment.

    Article  Google Scholar 

  36. Thompson SK, Jamieson GG, Myers JC, Chin KF, Watson DI, Devitt PG. Recurrent heartburn after laparoscopic fundoplication is not always recurrent reflux. J Gastrointest Surg. 2007;11(5):642–7.

    Article  Google Scholar 

  37. Tatum RP, Soares RV, Figueredo E, Oelschlager BK, Pellegrini CA. High-resolution manometry in evaluation of factors responsible for fundoplication failure. J Am Coll Surg. 2010;210(5):611–7. https://doi.org/10.1016/j.jamcollsurg.2009.12.023.

    Article  PubMed  Google Scholar 

  38. Rebecchi F, Allaix ME, Giaccone C, Morino M. Gastric emptying as a prognostic factor for long-term results of total laparoscopic fundoplication for weakly acidic or mixed reflux. Ann Surg. 2013;258(5):831–7.

    Article  Google Scholar 

  39. Farrell TM, Richardson WS, Halkar R, Lyon CP, Galloway KD, Waring JP, et al. Surgical endoscopy Nissen fundoplication improves gastric motility in patients with delayed gastric emptying. Surg Endosc. 2001;15:271–4.

    Article  CAS  Google Scholar 

  40. Banki F, Kaushik C, Roife D, Chawla M, Casimir R, Iii CCM. The American journal of surgery Laparoscopic reoperative antireflux surgery : a safe procedure with high patient satisfaction and low morbidity. Am J Surg. 2016;212:1115–20. https://doi.org/10.1016/j.amjsurg.2016.09.011.

    Article  PubMed  Google Scholar 

  41. Banki F, Weaver M, Roife D, Kaushik C, Khanna A, Ochoa K, et al. Laparoscopic reoperative antireflux surgery is more cost-effective than open approach. J Am Coll Surg. 2017;225(2):235–42. https://doi.org/10.1016/j.jamcollsurg.2017.03.019.

    Article  PubMed  Google Scholar 

  42. del Campo SEM, Mansfield SA, Suzo AJ, Hazey JW, Perry KA. Laparoscopic redo fundoplication improves disease-specific and global quality of life following failed laparoscopic or open fundoplication. Surg Endosc. 2017;31(11):4649–55.

    Article  Google Scholar 

  43. Tolboom RC, Draaisma WA, Broeders IAMJ. Evaluation of conventional laparoscopic versus robot-assisted laparoscopic redo hiatal hernia and antireflux surgery: a cohort study. J Robot Surg. 2016;10(1):33–9.

    Article  Google Scholar 

  44. Awais O, Luketich JD, Schuchert MJ, Morse CR, Wilson J, Gooding WE, et al. Reoperative antireflux surgery for failed fundoplication: an analysis of outcomes in 275 patients. Ann Thorac Surg. 2011;92(3):1083–90. https://doi.org/10.1016/j.athoracsur.2011.02.088.

    Article  PubMed  Google Scholar 

  45. Bradley D, Louie B, Farivar A, Wilshire C, Baik P, Aye R. Assessment and reduction of diaphragmatic tension during hiatal hernia repair. Surg Endosc. 2015;29(4):796–804.

    Article  Google Scholar 

  46. Oelschlager B, Pellegrini C, Hunter J, Brunt M, Soper N, Sheppard B, et al. Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair: long term follow-up from a multicenter, prospective, randomized trial. J Am Coll Surg. 2011;213(4):461–8.

    Article  Google Scholar 

  47. Obeid N, Velanovich V. The choice of primary repair or mesh repair for paraesophageal hernia: a decision analysis based on utility scores. Ann Surg. 2013;257(4):655–64.

    Article  Google Scholar 

  48. Stadlhuber R, Sherif A, Mittal S, Fitzqibbons R, Michael B, Hunter J, et al. Mesh complications after prosthetic reinforcement of hiatal closure: a 28-case series. Surg Endosc. 2009;23(6):1219–26.

    Article  Google Scholar 

  49. Higgins R, Schumm M, Bosler M, Gould J. Pre-existing mesh at the hiatus in revisional surgery does not result in increased morbidity: a case control evaluation. J Laparoendosc Adv Surg Tech A. 2017;27(10):997–1001.

    Article  Google Scholar 

  50. Musunuru S, Gould JC. Perioperative outcomes of surgical procedures for symptomatic fundoplication failure: a retrospective case-control study. Surg Endosc. 2012;26(3):838–42.

    Article  Google Scholar 

  51. Wilshire CL, Louie BE, Shultz D, Jutric Z, Farivar AS, Aye RW. Clinical outcomes of reoperation for failed antireflux operations Presented at the Poster Session of the Fifty-first Annual Meeting of the Society of Thoracic Surgeons, San Diego, CA January 24–28, 2015. Ann Thorac Surg. 2016;101(4):1290–6. https://doi.org/10.1016/j.athoracsur.2015.10.027.

    Article  PubMed  Google Scholar 

  52. Patterson EJ, Davis DG, Khajanchee Y, Swanstro LL. Comparison of objective outcomes following laparoscopic Nissen fundoplication vs laparoscopic gastric bypass in the morbidly obese with heartburn. Surg Endosc. 2003;17(10):1561–5.

    Article  CAS  Google Scholar 

  53. Stefanidis D, Navarro F, Augenstein VA, Gersin KS, Heniford BT. Laparoscopic fundoplication takedown with conversion to Roux-en-Y gastric bypass leads to excellent reflux control and quality of life after fundoplication failure. Surg Endosc. 2012;26(12):3521–7.

    Article  Google Scholar 

  54. Kellogg TA, Andrade R, Maddaus M, Slusarek B, Buchwald H, Ikramuddin S. Anatomic findings and outcomes after antireflux procedures in morbidly obese patients undergoing laparoscopic conversion to Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3(1):52–7.

    Article  Google Scholar 

  55. Raftopoulos I, Awais O, Courcoulas AP, Luketich JD. Laparoscopic gastric bypass after antireflux surgery for the treatment of gastroesophageal reflux in morbidly obese patients: initial experience. Obes Surg. 2004;14(10):1373–80.

    Article  Google Scholar 

  56. Madalosso CAS, Gurski RR, Callegari-Jacques SM, Navarini D, Mazzini G, Da Silva Pereira M. The impact of gastric bypass on gastroesophageal reflux disease in morbidly obese patients. Ann Surg. 2016;263(1):110–6.

    Article  Google Scholar 

  57. Frezza EE, Ikramuddin S, Gourash W, Rakitt T, Kingston A, Luketich J, et al. Symptomatic improvement in gastroesophageal reflux disease (GERD) following laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2002;16:1027–31.

    Article  CAS  Google Scholar 

  58. Weber CE, Kanani Z, Schumm M, Helm M, Gould JC. Roux-en-Y gastric bypass as a salvage procedure in complicated patients with failed fundoplication(s). Surg Endosc. 2019;33:738–44.

    Article  Google Scholar 

  59. Makris KI, Panwar A, Willer BL, Ali A, Sramek KL, Lee TH, et al. The role of short-limb Roux-en-Y reconstruction for failed antireflux surgery: a single-center 5-year experience. Surg Endosc. 2012;26:1279–86.

    Article  Google Scholar 

  60. Ibele A, Garren M, Gould J. The impact of previous fundoplication on laparoscopic gastric bypass outcomes: a case-control evaluation. Surg Endosc. 2012;26:177–81.

    Article  Google Scholar 

  61. Williams VA, Watson TJ, Gellersen O, Feuerlein S, Molena D, Sillin LF, et al. Gastrectomy as a remedial operation for failed fundoplication. J Gastrointest Surg. 2007;11:29–35.

    Article  Google Scholar 

  62. •• Mittal SK, Légner A, Tsuboi K, Juhasz A, Bathla L, Lee TH. Roux-en-Y reconstruction is superior to redo fundoplication in a subset of patients with failed antireflux surgery. Surg Endosc. 2013;27(3):927–35. This study compares the outcomes of complicated patients with failed fundoplication to undergo either salvage gastric bypass or reoperative fundoplication. Patients with more complex pathology benefit more from gastric bypass despite a higher complication rate.

    Article  Google Scholar 

  63. Zainabadi K, Courcoulas AP, Awais O, Raftopoulos I. Laparoscopic revision of Nissen fundoplication to Roux-en-Y gastric bypass in morbidly obese patients. Surg Endosc. 2008;22(12):2737–40.

    Article  Google Scholar 

  64. Awais O, Luketich JD, Tam J, Irshad K, Schuchert MJ, Landreneau RJ, et al. Roux-en-Y near esophagojejunostomy for intractable gastroesophageal reflux after antireflux surgery. Ann Thorac Surg. 2008;85:1954–61.

    Article  Google Scholar 

  65. Yamamoto SR, Hoshino M, Nandipati KC, Lee TH, Mittal SK. Long-term outcomes of reintervention for failed fundoplication: redo fundoplication versus Roux-en-Y reconstruction. Surg Endosc. 2014;28(1):42–8.

    Article  Google Scholar 

  66. Singhal S, Kirkpatrick DR, Masuda T, Gerhardt J, Mittal SK. Primary and redo antireflex surgery: outcomes and lessons learned. J Gastrointest Surg. 2018;22:177–86.

    Article  Google Scholar 

  67. Furnée EJB, Draaisma WA, Broeders IAMJ, Smout AJPM, Vlek ALM, Gooszen HG. Predictors of symptomatic and objective outcomes after surgical reintervention for failed antireflux surgery. Br J Surg. 2008;95(11):1369–74.

    Article  Google Scholar 

  68. Legner A, Tsuboi K, Bathla L, Lee T, Morrow LE, Mittal SK. Reoperative antireflux surgery for dysphagia. Surg Endosc. 2011;25:1160–7.

    Article  Google Scholar 

  69. Aly A, Jamieson GG. Reflux after oesophagectomy. Br J Surg. 2004;91:137–41.

    Article  CAS  Google Scholar 

  70. Masabni K, Kandagatla P, Popoff A, Rubinfeld I, Hammoud ZT. Is esophagectomy for benign conditions benign? Ann Thorac Surg. 2018;106(2):368–74.

    Article  Google Scholar 

  71. Huang X, Chen S, Zhao H, Zeng X. Efficacy of transoral incisionless fundoplication (TIF) for the treatment of GERD: a systematic review with meta-analysis. Surg Endosc. 2017;31:1032–44.

    Article  Google Scholar 

  72. Bell RCW, Hufford RJ, Fearon J, Freeman KD. Revision of failed traditional fundoplication using EsophyX® transoral fundoplication. Surg Endosc. 2013;27(3):761–7.

    Article  Google Scholar 

  73. Furnée EJB, Broeders JAJL, Draaisma WA, Schwartz MP, Hazebroek EJ, Smout AJPM, et al. Laparoscopic Nissen fundoplication after failed EsophyX® fundoplication. Br J Surg. 2010;97(7):1051–5.

    Article  Google Scholar 

  74. Ashfaq A, Daniel Rhee HK, Harold KL. Revision of failed transoral incisionless fundoplication by subsequent laparoscopic Nissen fundoplication. World J Gastroenterol. 2014;20(45):17115–9.

    Article  Google Scholar 

  75. Witteman BPL, Kessing BF, Snijders G, Koek GH, Conchillo JM, Bouvy ND. Revisional laparoscopic antireflux surgery after unsuccessful endoscopic fundoplication. Surg Endosc. 2013;27(6):2231–6.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jon C. Gould.

Ethics declarations

Conflict of Interest

Jon Gould is a consultant for Ethicon and Gore.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Esophagus

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Munie, S., Nasser, H. & Gould, J.C. Salvage Options for Fundoplication Failure. Curr Gastroenterol Rep 21, 41 (2019). https://doi.org/10.1007/s11894-019-0709-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11894-019-0709-2

Keywords

Navigation