Abstract
Background
Obesity has been implicated as an important risk factor for fundoplication failure. However, the mechanism of fundoplication in obese patients is not fully understood. Our objective is to evaluate the patterns of failure in relation to the body mass index (BMI) undergoing re-operative intervention after failed fundoplication.
Methods
After Institutional Review Board approval, the patients who underwent re-operative intervention for failed fundoplication between November 2008 and December 2013 were identified. Patients were classified into three groups: non-obese, obese, and morbidly obese (<30, 30–35, >35 BMI, respectively). Pre-operative assessment and operative procedure performed were compared between the groups.
Results
One hundred twenty-four patients satisfied study criteria. Non-obese patients (53.2 %) had significantly more dysphagia as an indication for re-operative procedure (obese 31.6 %, p < 0.05; morbidly 16.7 %, p < 0.05). Obese and morbidly obese patients had significantly higher incidence of recurrent hiatal hernia than non-obese patients (88.7 vs. 65.6 %, p < 0.05). Morbidly obese patients had significantly higher incidence of disrupted fundoplication than non-obese patients (41.7 vs. 19.4 %, p < 0.05).
Conclusion
Similar anatomical failure patterns of state of fundoplication and recurrent hiatal hernia were noted between obese patients and morbidly obese patients and were distinct from non-obese patients.
Similar content being viewed by others
References
World Health Organization. Obesity. (2008) http://www.who.int/topics/obesity/en/
Corley DA, Kubo A. Body mass index and gastroesophageal reflux disease: A systematic review and meta-analysis. Am J Gastroenterol 2006;108:2619–2628.
Wajed SA, Streets CG, Bremner CG, DeMeester TR. Elevated body mass disrupts the barrier to gastroesophageal reflux. Arch Surg 2001;136:1014–1019.
EL-Serag HB, Ergun GA, Pandolfino J, Fitzgerald S, Tran T, Kramer JR. Obesity increases oesophageal acid exposure. Gut 2007;56:749–755.
Dallemagne B, Weerts J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, Jehaes C. Clinical results of laparoscopic fundoplication at ten years after surgery. Surg Endosc 2006;20:159–165.
Perez AR, Moncure AC, Rattner DW. Obesity adversely affects the outcome of antireflux operations. Surg Endosc 2001;15:986–989.
D’Alessio MJ, Arnaoutakis D, Giarelli N, Villadolid DV, Rosemurgy AS. Obesity is not a contraindication to laparoscopic Nissen fundoplication. J Gastrointest Surg 2005:9:949–954.
Mechanick JI, Youdim A, Jones DB, Garvey WT, Hurley DL, McMahon MM, Heinberg LJ, Kushner R, Adams TD, Shikora S, Dixon JB, Brethauer S. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update. Endocr Pract 2013;19(2):337–372.
Mittal SK, Legner A, Tsuboi K, Juhasz A, Bathla L, Lee TH. Roux-en-Y reconstruction is superior to redo fundoplication in a subset of patients with failed antireflux surgery. Surg Endosc 2013;27:927–935.
Mittal SK, Juhasz A, Ramanan B, Hoshino M, Lee TH, Fillipi CJ. A proposed classification for uniform endoscopic description of surgical fundoplication. Surg Endosc 2014;28:1103–1109.
Makris KI, Lee T, Mittal SK. Roux-en-Y reconstruction for failed fundoplication. J Gastrointest Surg 2009;13:2226–2232.
Kellogg TA, Andrade R, Maddaus M, Slusarek B, Buchwald H, Ikramuddin S. Anatomic findings and outcomes after antireflux procedures in morbidly obese patients undergoing laparoscopic conversion to Roux-en-Y gastric bypass. Surg Obes Relat Dis 2007;3:52–57.
Perry Y, Courcoulas AP, Fernando HC, Buenaventura PO, McCaughan JS, Luketich JD. Laparoscopic Roux-en-Y gastric bypass for recalcitrant gastroesophageal reflux disease in morbidly obese patients. JSLS 2004;8:19–23.
Patterson EJ, Davis DG, Khajanchee Y, Swanstrom LL. Comparison of objective outcomes following laparoscopic Nissen fundoplication vs laparoscopic gastric bypass in the morbidly obese with heartburn. Surg Endosc 2003;17:1561–1565.
van Beek DB, Auyang ED, Soper NJ. A comprehensive review of laparoscopic redo fundoplication. Surg Endosc 2011;25:706–712.
Funch-Jensen P, Bendixen A, Iversen MG, Kehlet H. Complications and frequency of redo antireflux surgery in Denmark: a nationwide study, 1997–2005. Surg Endosc 2008;22:627–630.
Madalosso CA, Gurski RR, Callegari-Jacques SM, Navarini D, Thiesen V, Fornari F. The impact of gastric bypass on gastroesophageal reflux disease in patients with morbid obesity. Ann Surg 2010;251:244–248.
Makris KI, Panwar A, Willer BL, Ali A, Sramek KL, Lee TH, Mittal SK. The role of short-limb Roux-en-Y reconstruction for failed antireflux surgery: a single-center 5-year experience. Surg Endosc 2012;26:1279–1286.
Raftopoulos I, Awais O, Courcoulas AP, Luketich JD. Laparoscopic gastric bypass after antireflux surgery for the treatment of gastroesophageal reflux in morbidly obese patients: initial experience. Obes Surg 2004;14:1373–1380.
Acknowledgments
All authors have read the journal publication policy and have no conflicts of interest with regards to this paper.
Conflict of Interest
Drs. Akimoto, Nandipati, Kapoor, Yamamoto, Pallati, and Mittal have no conflicts of interest or financial ties to disclose.
Author information
Authors and Affiliations
Corresponding author
Appendix
Appendix
Rights and permissions
About this article
Cite this article
Akimoto, S., Nandipati, K.C., Kapoor, H. et al. Association of Body Mass Index (BMI) with Patterns of Fundoplication Failure: Insights Gained. J Gastrointest Surg 19, 1943–1948 (2015). https://doi.org/10.1007/s11605-015-2907-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11605-015-2907-z