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Advanced Endoscopic Imaging for Barrett’s Esophagus: Current Options and Future Directions

  • Esophagus (MF Vela, Section Editor)
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Abstract

Barrett’s esophagus is the precursor to esophageal adenocarcinoma, one of the most rapidly increasing cancers in the United States. Given the poor prognosis of late-stage adenocarcinoma, endoscopic surveillance is recommended for subjects with Barrett’s esophagus to detect early neoplasia. Current guidelines recommend “random” four-quadrant biopsies taken every 1–2 cm throughout the Barrett’s segment. However, this only samples a minority of epithelium and has been shown to miss areas of endoscopically- inapparent neoplasia (high grade dysplasia or cancer). Recent efforts have focused on developing novel diagnostic imaging technologies to detect the subtle epithelial changes associated with dysplasia and neoplasia in Barrett’s esophagus. Some of these modalities serve as “red flag” technologies designed to detect areas of abnormality within large surface areas. Other technologies serve to characterize areas of visible abnormality, offering a higher spatial resolution to confirm/exclude the presence of neoplasia. This review summarizes several available and evolving imaging technologies used in the endoscopic diagnosis and surveillance of Barrett’s associated neoplasia.

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Disclosure

Dr. R. Richards-Kortum has received grant funding and travel support from the NIH and patents, royalties and stock options from Remicalm. No other potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Division of Gastroenterology, The Mount Sinai Medical Center, One Gustave Levy Place, Unit 1069, New York, NY, 10029, USA

    Michelle H. Lee & Sharmila Anandasabapathy

  2. Mount Sinai School of Medicine, One Gustave Levy Place, Unit 1069, New York, NY, 10029, USA

    Kristin Buterbaugh

  3. Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA

    Rebecca Richards-Kortum

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  1. Michelle H. Lee
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  2. Kristin Buterbaugh
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  3. Rebecca Richards-Kortum
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  4. Sharmila Anandasabapathy
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Correspondence to Sharmila Anandasabapathy.

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Lee, M.H., Buterbaugh, K., Richards-Kortum, R. et al. Advanced Endoscopic Imaging for Barrett’s Esophagus: Current Options and Future Directions. Curr Gastroenterol Rep 14, 216–225 (2012). https://doi.org/10.1007/s11894-012-0259-3

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