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Drug-Induced Pancreatitis

  • Pancreas (CE Forsmark, Section Editor)
  • Published:
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Abstract

Drugs are thought to be a rare cause for acute pancreatitis; however 525 different drugs are listed in the World Health Organization (WHO) database suspected to cause acute pancreatitis as a side effect. Many of them are widely used to treat highly prevalent diseases. The true incidence is not entirely clear since only few systematic population based studies exist. The majority of the available data are derived from case reports or case control studies. Furthermore, the causality for many of these drugs remains elusive and for only 31 of these 525 dugs a definite causality was established. Definite proof for causality is defined by the WHO classification if symptoms reoccur upon rechallenge. In the actual algorithm the diagnosis is confirmed if no other cause of acute pancreatitis can be detected, and the patient is taking one of the suspected drugs.

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Acknowledgements

The authors’ work is supported by the Alfried-Krupp-von-Bohlen-und-Hahlbach-Foundation (Graduate Schools Tumour Biology and Free Radical Biology), the Deutsche Krebshilfe/ Dr. Mildred-Scheel-Stiftung (109102), the Deutsche Forschungsgemeinschaft (DFG GRK840-E3/E4, MA 4115/1-2/3, NI 1297/1-1), the Federal Ministry of Education and Research (BMBF GANI-MED 03152061A and BMBF 0314107) and the European Union (EU-FP-7: EPC-TM and EU-FP7-REGPOT-2010-1).

Disclosure

Dr. J. Mayerle has worked as a consultant for Astra Zeneca and has received honoraria from Falk; Drs. C. Nitsche, S. Maertin, J Scheiber, C. A. Ritter, and M. M. Lerch reported no potential conflicts of interest relevant to this article.

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Authors and Affiliations

  1. Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Friedrich-Loeffler-Strasse 23a, 17475, Greifswald, Germany

    Claudia Nitsche, Sandrina Maertin, Jonas Scheiber, Markus M. Lerch & Julia Mayerle

  2. Department of Clinical Pharmacy, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany

    Christoph A. Ritter

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  1. Claudia Nitsche
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Correspondence to Julia Mayerle.

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Nitsche, C., Maertin, S., Scheiber, J. et al. Drug-Induced Pancreatitis. Curr Gastroenterol Rep 14, 131–138 (2012). https://doi.org/10.1007/s11894-012-0245-9

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