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Intraepithelial Lymphocytes: To Serve and Protect

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Abstract

The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical.

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Disclosure

Conflicts of interest: Dr. Sheridan’s institution has received grants from the Crohn’s and Colitis Foundation of America. Dr. Lefrançois’s laboratory has received grants from the National Institutes of Health.

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  1. Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Brian S. Sheridan & Leo Lefrançois

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  1. Brian S. Sheridan
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  2. Leo Lefrançois
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Correspondence to Leo Lefrançois.

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Sheridan, B.S., Lefrançois, L. Intraepithelial Lymphocytes: To Serve and Protect. Curr Gastroenterol Rep 12, 513–521 (2010). https://doi.org/10.1007/s11894-010-0148-6

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