Skip to main content
Log in

The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review

  • Macrovascular Complications in Diabetes (VR Aroda and A Getaneh, Section Editors)
  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Adult obesity and cardiovascular diseases are closely linked. Yet, the relationship of childhood and adolescent obesities with cardiovascular diseases in adulthood requires additional evidence. The goal of the review is to inspect the relationship between childhood- and adolescent-increased body mass index (BMI) and cardiovascular risk factors, fatal and non-fatal cardiovascular diseases in adulthood.

Recent Findings

Cardiovascular diseases in adulthood are linked by most of the studies to childhood and adolescent obesities.

Summary

Studies showed that childhood and adolescent obesities increased the incidence of cardiovascular disease risk factors and were linked to higher risk of cardiovascular morbidity and mortality in adulthood. Childhood and adolescent obesities were also associated, likely with a causal relationship, with an increased likelihood for various cardiovascular morbidities including ischemic heart disease, stroke, but also non-ischemic heart disease-related cardiac pathologies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014;311:806–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Baker JL, Olsen LW, Sørensen TIA. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007;357:2329–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents—a follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med. 1992;327:1350–5.

    Article  CAS  PubMed  Google Scholar 

  4. Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010;362:485–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Engeland A, Bjørge T, Søgaard AJ, Tverdal A. Body mass index in adolescence in relation to total mortality: 32-year follow-up of 227,000 Norwegian boys and girls. Am J Epidemiol. 2003;157:517–23.

    Article  PubMed  Google Scholar 

  6. Bjørge T, Engeland A, Tverdal A, Smith GD. Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. Am J Epidemiol. 2008;168:30–7.

    Article  PubMed  Google Scholar 

  7. Van Dam RM, Willett WC, Manson JE, Hu FB. The relationship between overweight in adolescence and premature death in women. Ann Intern Med. 2006;145:91–7.

    Article  PubMed  Google Scholar 

  8. World Health Report. Reducing risks, promoting healthy life. Geneva: World Health Organization; 2002. p. 2002.

    Google Scholar 

  9. Lloyd LJ, Langley-Evans SC, McMullen S. Childhood obesity and adult cardiovascular disease risk: a systematic review. Int J Obes. 2010;34:18–28.

    Article  CAS  Google Scholar 

  10. Joshi SM, Katre PA, Kumaran K, Joglekar C, Osmond C, Bhat DS, et al. Tracking of cardiovascular risk factors from childhood to young adulthood—the Pune Children’s Study. Int J Cardiol. 2014;175(1):176–8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365(20):1876–85.

    Article  CAS  PubMed  Google Scholar 

  12. Chorin E, Hassidim A, Hartal M, Havakuk O, Flint N, Ziv-Baran T, et al. Trends in adolescents obesity and the association between BMI and blood pressure: a cross-sectional study in 714,922 healthy teenagers. Am J Hypertens. 2015;28(9):1157–63.

    Article  PubMed  Google Scholar 

  13. Sabo RT, Lu Z, Daniels S, Sun SS. Serial childhood BMI and associations with adult hypertension and obesity: the Fels Longitudinal Study. Obesity (Silver Spring). 2012;20(8):1741–3.

    Article  Google Scholar 

  14. Park MH, Sovio U, Viner RM, Hardy RJ, Kinra S. Overweight in childhood, adolescence and adulthood and cardiovascular risk in later life: pooled analysis of three British birth cohorts. PLoS One. 2013;8(7):e70684.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Li L, Pinot de Moira A, Power C. Predicting cardiovascular disease risk factors in midadulthood from childhood body mass index: utility of different cutoffs for childhood body mass index. Am J Clin Nutr. 2011;93(6):1204–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Rademacher ER, Jacobs DR Jr, Moran A, Steinberger J, Prineas RJ, Sinaiko A. Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults. J Hypertens. 2009;27(9):1766–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 2002;51(1):204–9.

    Article  CAS  PubMed  Google Scholar 

  18. Michalsky MP, Inge TH, Jenkins TM, Xie C, Courcoulas A, Helmrath M, Brandt ML, Harmon CM, Chen M, Dixon JB, Urbina EM; Teen-LABS Consortium. Cardiovascular risk factors after adolescent bariatric surgery. Pediatrics. 2018 ;141(2).

    Article  PubMed  Google Scholar 

  19. Koskinen J, Magnussen CG, Sinaiko A, Woo J, Urbina E, Jacobs DR Jr, Steinberger J, Prineas R, Sabin MA, Burns T, Berenson G, Bazzano L, Venn A, Viikari JSA, Hutri-Kähönen N, Raitakari O, Dwyer T, Juonala M. Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome, type 2 diabetes mellitus and carotid intima media thickness: the International Childhood Cardiovascular Cohort Consortium. J Am Heart Assoc. 2017;6(8).

  20. Sundaram ME, Berg RL, Economos C, Coleman LA. The relationship between childhood BMI and adult serum cholesterol, LDL, and ankle brachial index. Clin Med Res. 2014;12(1–2):33–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Schmidt M, Bøtker HE, Pedersen L, Sørensen HT. Young adulthood obesity and risk of acute coronary syndromes, stable angina pectoris, and congestive heart failure: a 36-year cohort study. Ann Epidemiol. 2014;24(5):356–361.e1.

    Article  PubMed  Google Scholar 

  22. DiPietro L, Mossberg HO, Stunkard AJ. A 40-year history of overweight children in Stockholm: life-time overweight, morbidity, and mortality. Int J Obes Relat Metab Disord. 1994;18:585–90.

    CAS  PubMed  Google Scholar 

  23. Lawlor DA, Martin RM, Gunnell D, Galobardes B, Ebrahim S, Sandhu J, et al. Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies. Am J Clin Nutr. 2006;83:767–73.

    Article  CAS  PubMed  Google Scholar 

  24. Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ. Early growth and coronary heart disease in later life: longitudinal study. BMJ. 2001;322:949–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. •• Twig G, Yaniv G, Levine H, Leiba A, Goldberger N, Derazne E, et al. Body-mass index in 2.3 million adolescents and cardiovascular death in adulthood. N Engl J Med. 2016;374(25):2430–40. A nationwide study that showed and examined the association between adolescent obesity and midlife mortality. It showed that mortality risk from cardiovascular was nearly two- and fourfold among adolescents with overweight and obesity respectively and was evident already after 10 years of follow-up. The mortality risk for the latter persisted extensive sensitivity analyses including limiting the study sample to overweight and obese adolescents that at baseline were of unimpaired health.

    Article  PubMed  Google Scholar 

  26. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JSA, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood. Circulation. 2005;112:1486–93.

    Article  PubMed  Google Scholar 

  27. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290(17):2277–83.

    Article  CAS  PubMed  Google Scholar 

  28. Yan Y, Hou D, Liang Y, Zhao X, Hu Y, Liu J, et al. Tracking body mass index from childhood to adulthood for subclinical cardiovascular diseases at adulthood. J Am Coll Cardiol. 2016;67(8):1006–7.

    Article  PubMed  Google Scholar 

  29. Tirosh A, Shai I, Afek A, Dubnov-Raz G, Ayalon N, Gordon B, et al. Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med. 2011;364(14):1315–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Mangner N, Scheuermann K, Winzer E, Wagner I, Hoellriegel R, Sandri M, et al. Childhood obesity: impact on cardiac geometry and function. JACC Cardiovasc Imaging. 2014;7(12):1198–205.

    Article  PubMed  Google Scholar 

  31. Toprak A, Wang H, Chen W, Paul T, Srinivasan S, Berenson G. Relation of childhood risk factors to left ventricular hypertrophy (eccentric or concentric) in relatively young adulthood (from the Bogalusa Heart Study). Am J Cardiol. 2008;101(11):1621–5.

    Article  PubMed  Google Scholar 

  32. Lai CC, Sun D, Cen R, Wang J, Li S, Fernandez-Alonso C, et al. Impact of long-term burden of excessive adiposity and elevated blood pressure from childhood on adulthood left ventricular remodeling patterns: the Bogalusa Heart Study. J Am Coll Cardiol. 2014;64(15):1580–7.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Wilborn C, Beckham J, Campbell B, Harvey T, Galbreath M, La Bounty P, Nassar E, Wismann J, Kreider R. Obesity: prevalence, theories, medical consequences, management, and research directions. J Int Soc Sports Nutr.

  34. Guven A, Ozgen T, Gungor O, Aydin M, Baysal K. Association between the corrected QT interval and carotid artery intima-media thickness in obese children. J Clin Res Pediatr Endocrinol. 2010;2:21–7.

    Article  PubMed  PubMed Central  Google Scholar 

  35. El-Assaad I, Al-Kindi SG, Saarel EV, Aziz PF. Lone pediatric atrial fibrillation in the United States: analysis of over 1500 cases. Pediatr Cardiol. 2017;38(5):1004–9.

    Article  PubMed  Google Scholar 

  36. Jayaraman R, Reinier K, Nair S, Aro AL, Uy-Evanado A, Rusinaru C, et al. Risk factors of sudden cardiac death in the young: a multiple-year community-wide assessment. Circulation. 2018;137(15):1561–70.

    Article  PubMed  Google Scholar 

  37. Rosengren A, Åberg M, Robertson J, Waern M, Schaufelberger M, Kuhn G, et al. Body weight in adolescence and long-term risk of early heart failure in adulthood among men in Sweden. Eur Heart J. 2017;38(24):1926–33.

    PubMed  Google Scholar 

  38. •• Twig G, Ben-Ami Shor D, Furer A, Levine H, Derazne E, Goldberger N, et al. Adolescent body mass index and cardiovascular disease-specific mortality by midlife. J Clin Endocrinol Metab. 2017;102(8):3011–20. A nationwide study that examined the association between adolescent obesity and cardiovascular-specific mortality showing that overweight and obesity at adolescent were associated with mortality related to fatal arrhythmias, hypertensive heart disease, cardiomyopathies, arterial disease, heart failure, and pulmonary embolism.

    Article  PubMed  Google Scholar 

  39. Puurunen MK, Gona P, Larson MG, Murabito JM, Magnani JW, O’Donnell CJ. Epidemiology of venous thromboembolism in the Framingham Heart Study. Thromb Res. 2016;145:27–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Stein PD, Matta F, Goldman J. Obesity and pulmonary embolism: the mounting evidence of risk and the mortality paradox. Thromb Res. 2011;128(6):518–23.

    Article  CAS  PubMed  Google Scholar 

  41. Falkstedt D, Hemmingsson T, Rasmussen F, Lundberg I. Body mass index in late adolescence and its association with coronary heart disease and stroke in middle age among Swedish men. Int J Obes. 2007;31(5):777–83.

    Article  CAS  Google Scholar 

  42. Furer A, Afek A, Orr O, Gershovitz L, Landau Rabbi M, Derazne E, et al. Sex-specific associations between adolescent categories of BMI with cardiovascular and non-cardiovascular mortality in midlife. Cardiovasc Diabetol. 2018;17(1):80.

    Article  PubMed  PubMed Central  Google Scholar 

  43. •• Geng T, Smith CE, Li C, Huang T. Childhood BMI and adult type 2 diabetes, coronary artery diseases, chronic kidney disease, and cardiometabolic traits: a Mendelian randomization analysis. Diabetes Care. 2018;41(5):1089–96. The first Mendelian randomization study that proves causality between obesity and deleterious cardiovascular metabolic comorbidities

    Article  PubMed  Google Scholar 

  44. Würtz P, Wang Q, Kangas AJ, Richmond RC, Skarp J, Tiainen M, et al. Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med. 2014;11(12):e1001765.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Jeffreys M, McCarron P, Gunnell D, McEwen J, Smith GD. Body mass index in early and mid-adulthood, and subsequent mortality: a historical cohort study. Int J Obes Relat Metab Disord. 2003;27:1391–7.

    Article  CAS  PubMed  Google Scholar 

  46. Gray L, Lee IM, Sesso HD, Batty GD. Body weight in early and mid-adulthood in relation to subsequent coronary heart disease mortality: 80-year follow-up in the Harvard Alumni Study. Arch Intern Med. 2011;171:1768–70.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Dietz WH. Childhood weight affects adult morbidity and mortality. J Nutr. 1998;128:411S–4S.

    Article  CAS  PubMed  Google Scholar 

  48. Must A. Does overweight in childhood have an impact on adult health? Nutr Rev. 2003;61(4):139–42.

    Article  PubMed  Google Scholar 

  49. Bervoets L, Massa G. Defining morbid obesity in children based on BMI 40 at age 18 using the extended international (IOTF) cut-offs. Pediatr Obes. 2014;9(5):e94–8.

    Article  CAS  PubMed  Google Scholar 

  50. Zabarsky G, Beek C, Hagman E, Pierpont B, Caprio S, Weiss R. Impact of severe obesity on cardiovascular risk factors in youth. J Pediatr. 2018;192:105–14.

    Article  PubMed  Google Scholar 

  51. • Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med. 2015;373(14):1307–17. An updated report showing the association between common metabolic comorbidities with the different classes of obesity among children and adolescents. This opposed to most studies that grouped adolescents with obesity as a single homogenous group.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank Dr. Orit Pinhas-Hamiel for her comments on a later version of this manuscript. This review is dedicated to prof. Jeremy D. Kark, one of the leading epidemiologists in Israel, an outstanding scientist, and mentor, who has dedicated the last five decades to study key issues in adolescent health.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gilad Twig.

Ethics declarations

Conflict of Interest

Adir Sommer and Gilad Twig declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Macrovascular Complications in Diabetes

Electronic Supplementary Material

ESM 1

(DOCX 89.5 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sommer, A., Twig, G. The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review. Curr Diab Rep 18, 91 (2018). https://doi.org/10.1007/s11892-018-1062-9

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11892-018-1062-9

Keywords

Navigation