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Gender and Sex Differences in Adipose Tissue

  • Obesity (J McCaffery, Section Editor)
  • Published:
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Abstract

Purpose of Review

As the ongoing epidemic of adult and childhood obesity grows, it puts a greater burden on individuals and the healthcare system due to increased prevalence of obesity-associated diseases. An important area that has gained much attention recently is the sex and gender difference related to obesity and associated complications. Basic science and clinical studies have now improved our understanding of obesity and have discovered adipose tissue biology to be key in metabolism.

Recent Findings

There is evidence related to the sex dichotomy in obesity in a variety of areas including adipocyte function, sex hormone effects, genetics, and metabolic inflammation leading to critical differences in adipose tissue biology.

Summary

The sex and gender difference in adipose tissue is a factor that should be considered when studying an individuals’ risk for obesity and metabolic dysfunction. This understanding is important for strategizing treatment and prevention measures.

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  1. Pediatric Endocrinology, University of Michigan Medical School, Medical Professional Building, D1205 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5718, USA

    Eric Chang, Mita Varghese & Kanakadurga Singer

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  1. Eric Chang
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Chang, E., Varghese, M. & Singer, K. Gender and Sex Differences in Adipose Tissue. Curr Diab Rep 18, 69 (2018). https://doi.org/10.1007/s11892-018-1031-3

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