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Type 2 Diabetes in Youth: New Lessons from the SEARCH Study

  • Pediatric Type 2 and Monogenic Diabetes (PS Zeitler and O Pinhas-Hamiel, Section Editors)
  • Published:
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Abstract

Purpose of Review

The purpose of this review is to provide an update on the recent body of evidence emerging for type 2 diabetes as identified through the SEARCH for Diabetes in Youth study.

Recent Findings

This body of evidence illustrates that type 2 diabetes continues to increase in incidence, although this increase may be partially attributable to increased surveillance. Disease management is influenced by the transition from adolescent to adult care and psychosocial factors may also contribute. This evidence also describes a high prevalence of disease-associated complications and comorbidities. Risk factors for cardiovascular disease are also highly prevalent.

Summary

The SEARCH for Diabetes in Youth study continues to inform our understanding of the descriptive epidemiology and natural history of type 2 diabetes in youth. As the cohort matures, new opportunities emerge for building on our understanding of how youth-onset type 2 diabetes impacts future health.

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Funding Support

The SEARCH for Diabetes in Youth Cohort Study (1UC4DK108173-01) is funded by the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases and supported by the Centers for Disease Control and Prevention (CDC). The Population Based Registry of Diabetes in Youth Study (RFP DP15-002) is funded by the CDC and supported by the NIH, National Institute of Diabetes and Digestive and Kidney Diseases. Sites: Kaiser Permanente Southern California (U18DP006133, U48/CCU919219, U01 DP000246, and U18DP002714), University of Colorado–Denver (U18DP006139, U48/CCU819241-3, U01 DP000247, and U18DP000247-06A1), Cincinnati’s Children’s Hospital Medical Center (U18DP006134, U48/CCU519239, U01 DP000248, and 1U18DP002709), University of North Carolina at Chapel Hill (U18DP006138, U48/CCU419249, U01 DP000254, and U18DP002708), Seattle Children’s Hospital (U18DP006136, U58/CCU019235-4, U01 DP000244, and U18DP002710-01), and Wake Forest University School of Medicine (U18DP006131, U48/CCU919219, U01 DP000250, and 200-2010-35171). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention and the National Institute of Diabetes and Digestive and Kidney Diseases.

Author information

Authors and Affiliations

  1. Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27599, USA

    Elizabeth T. Jensen

  2. Department of Epidemiology, Colorado School of Public Health, 13001 E 17th Place – B119, Aurora, CO, 80045, USA

    Dana Dabelea

  3. Department of Pediatrics, University of Colorado School of Medicine, 13123 E. 16th Ave - B065, Aurora, CO, 80045, USA

    Dana Dabelea

Authors
  1. Elizabeth T. Jensen
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  2. Dana Dabelea
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Corresponding author

Correspondence to Dana Dabelea.

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Conflict of Interest

Elizabeth T. Jensen and Dana Dabelea have no conflicts of interest to report.

Human and Animal Rights and Informed Consent

Local IRBs at each of the five clinical sites and at the SEARCH for Diabetes Coordinating Center provided Human Subjects approval for study implementation. The SEARCH for Diabetes in Youth study obtains written informed consent from participants > 18 years of age or their parents of legal guardians if < 18 years of age. Assent is obtained in accordance with local IRB requirements.

Additional information

This article is part of the Topical Collection on Pediatric Type 2 and Monogenic Diabetes

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Jensen, E.T., Dabelea, D. Type 2 Diabetes in Youth: New Lessons from the SEARCH Study. Curr Diab Rep 18, 36 (2018). https://doi.org/10.1007/s11892-018-0997-1

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  • DOI: https://doi.org/10.1007/s11892-018-0997-1

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