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The Negative Effects of Obesity and Poor Glycemic Control on Cognitive Function: A Proposed Model for Possible Mechanisms

  • Obesity (J McCaffery, Section Editor)
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Abstract

Obesity has reached epidemic proportions and is a contributor to many adverse health outcomes, including increased risk for dementia and adverse structural and functional brain changes. Milder forms of cognitive impairment in multiple domains can also be found in obese individuals of all ages that are believed to stem from brain abnormalities long prior to onset of neurologic conditions such as dementia. However, the mechanisms for adverse brain changes and subsequent cognitive dysfunction in obesity are complex and poorly understood. This paper proposes a possible etiologic model for obesity associated cognitive impairment with emphasis on the role of poor glycemic control and conditions like type 2 diabetes mellitus. Clinical implications associated with treatment of obesity in persons with cognitive deficits in addition to the cognitive promoting effects of weight loss surgery are also discussed.

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Michael L. Alosco and John Gunstad declare that they have no conflict of interest.

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  1. Department of Psychology, Kent State University, 238 Kent Hall Addition, Kent, OH, 44242, USA

    Michael L. Alosco & John Gunstad

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  1. Michael L. Alosco
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  2. John Gunstad
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Correspondence to John Gunstad.

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Alosco, M.L., Gunstad, J. The Negative Effects of Obesity and Poor Glycemic Control on Cognitive Function: A Proposed Model for Possible Mechanisms. Curr Diab Rep 14, 495 (2014). https://doi.org/10.1007/s11892-014-0495-z

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