Skip to main content

Advertisement

Log in

Origins of and Recognition of Micronutrient Deficiencies After Gastric Bypass Surgery

  • Published:
Current Diabetes Reports Aims and scope Submit manuscript

Abstract

Roux-en-Y gastric bypass surgery remains the major surgical option for individuals with medically complicated obesity. The importance of preoperative evaluation to permit identification of micronutrient deficiencies is being re-evaluated. The risk of complications related to pregnancy after gastric bypass supports careful follow-up. Micronutrient deficiencies are common in postoperative gastric bypass patients, despite the suggested use of routine vitamin and mineral supplements after surgery. Copper deficiency must be considered as an origin for visual disorders after gastric bypass. Vitamin D deficiency with metabolic bone disease remains common after gastric bypass and the results suggest that the present postoperative supplements of calcium and vitamin D are inadequate. Major nutritional complications of bariatric surgery are occurring more than 20 years after surgery. There is no evidence for intestinal adaptation as there remains decreased intestinal absorption of iron up to 18 months after gastric bypass surgery. This article supports ongoing examination of nutritional complications after gastric bypass surgery and supports the notion that the daily doses of micronutrient supplements, such as vitamin D, may need to be revised.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Flegal KM, Carroll MD, Ogden CL, Curtin LR.: Prevalence and trends in obesity among US adults, 1999–2008. JAMA 2010, 303(3): 235–41.

    Article  PubMed  CAS  Google Scholar 

  2. Buchwald H, Oien DM. Metabolic/bariatric surgery Worldwide 2008.: Obes Surg 2009, 19: 1605–1611.

    Article  PubMed  Google Scholar 

  3. Makary MA, Clarke JM, Shore AD, et al.: Medication utilization and annual health care costs in patients with type 2 diabetes mellitus before and after bariatric surgery. Arch Surg 2010, 145(8): 726–31.

    Article  PubMed  Google Scholar 

  4. Sechi GP. Dietary supplements and the risk of Wernicke’s encephalopathy. Clin Pharmacol Ther 2010; 88: 164.

    Article  PubMed  Google Scholar 

  5. Schweiger C, Weiss R, Berry E, et al.: Nutritional deficiencies in bariatric surgery candidates. Obes Surg 2010, 20(2): 193–7.

    Article  PubMed  Google Scholar 

  6. Gehrer S, Kern B, Peters T, et al.: Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic Roux-Y-gastric bypass (LTYGB)—a prospective study. Obes Surg 2010, 20(4): 447–53.

    Article  PubMed  Google Scholar 

  7. Shea MK, Booth SL, Gundberg CM, et al.: Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women. J Nutr 2010, 140(5): 1029–34.

    Article  PubMed  CAS  Google Scholar 

  8. Pereira S, Saboya C, Chaves G, et al.: Class III obesity and its relationship with the nutritional status of vitamin A in pre- and postoperative gastric bypass. Obes Surg 2009, 19(6): 738–44.

    Article  PubMed  Google Scholar 

  9. • Eerdekens A, Debeer A, Van Hoey G, et al.: Maternal bariatric surgery: adverse outcomes in neonates. Eur J Pediatr 2010, 169(2): 191–6. This report describes five babies with intracranial hemorrhage whose mothers had undergone bariatric surgery. The report suggests the potential for vitamin K deficiency.

    Article  PubMed  CAS  Google Scholar 

  10. Dalcanale L, Oliveira CP, Faintuch J, et al.: Long-term nutritional outcome after gastric bypass. Obes Surg 2010, 20(2): 181–7.

    Article  PubMed  Google Scholar 

  11. Toh SY, Zarshenas N, Jorgensen J.: Prevalence of nutrient deficiencies in bariatric patients. Nutrition 2009, 25(11–12): 1150–6.

    Article  PubMed  CAS  Google Scholar 

  12. Lakhani SV, Shah HN, Alexander K, Finelli FC, Kirkpatrick JR, Koch TR.: Small intestinal bacterial overgrowth and thiamine deficiency after Roux-en-Y gastric bypass surgery in obese patients. Nutrition Res 2008, 28(5): 293–298.

    Article  CAS  Google Scholar 

  13. Rounis E, Laing CM, Davenport A.: Acute neurological presentation due to copper deficiency in a hemodialysis patient following gastric bypass surgery. Clin Nephrol 2010, 74(5): 389–92.

    PubMed  CAS  Google Scholar 

  14. Spyropoulos C, Kehagias I, Panagiotopoulos S, et al.: Revisional bariatric surgery: 13-year experience from a tertiary institution. Arch Surg 2010, 145(2): 173–7.

    Article  PubMed  Google Scholar 

  15. • Naismith RT, Shepherd JB, Weihl CC, et al.: Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol 2009, 66(8): 1025–7. A patient 22 years after gastric bypass surgery developed bilateral blindness due to optic neuropathy. Copper deficiency was identified.

    Article  PubMed  Google Scholar 

  16. Jayakumar S, Micallef-Eynaud PD, Lyon TD, et al.: Acquired copper deficiency following prolonged jejunostomy feeds. Ann Clin Biochem 2005, 42(3), 227–231.

    Article  PubMed  CAS  Google Scholar 

  17. Genead MA, Fishman GA, Lindeman M.: Fundus white spots and acquired night blindness due to vitamin A deficiency. Doc Ophthalmol 2009, 119(3): 229–33.

    Article  PubMed  Google Scholar 

  18. • Al-Shoha A, Qui S, Palnitkar S, et al.: Osteomalacia with bone marrow fibrosis due to severe vitamin D deficiency after a gastrointestinal bypass operation for severe obesity. Endocr Pract 2009, 15(6): 528–33. This article discusses patients with bone biopsy-proven osteomalacia with marrow fibrosis; symptoms were present for 2 to 5 years after gastric bypass surgery. Significant improvement occurred after treatment with ergocalciferol (100,000 IU daily) and calcium carbonate (1 to 2.5 g daily).

    Article  PubMed  Google Scholar 

  19. Valderas JP, Velasco S, Solari S, et al.: Increase of bone resorption and the parathyroid hormone in postmenopausal women in the long-term after Roux-en-Y gastric bypass. Obes Surg 2009, 19(8): 1132–8.

    Article  PubMed  Google Scholar 

  20. Mechanick JI, Kushner RF, Sugerman HJ, Gonzalez-Campoy JM, Collazo-Clavell ML, Spitz AF, Apovian CM, Livingston EH, Brolin R, Sarwer DB, Anderson WA, Dixon J, Guven S.: American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient. Obesity 2009;17 Suppl 1:S1–70.

    PubMed  Google Scholar 

  21. • Signori C, Zalesin KC, Franklin B, et al.: Effect of gastric bypass on vitamin D and secondary hyperparathyroidism. Obes Surg 2010, 20(7): 949–52. Eighty-six percent of gastric bypass patients had preoperative vitamin D deficiency, whereas at the 1-year postoperative follow-up, 70% of patients still had evidence for inadequate blood levels of vitamin D.

    Article  PubMed  Google Scholar 

  22. Sung CC, Lee HS, Diang LK, et al.: Refractory diffuse bony pain 20 years after jejunoileal bypass. South Med J 2010, 103(6): 570–3.

    PubMed  Google Scholar 

  23. Ruz M, Carrasco F, Rojas P, et al.: Iron absorption and iron status are reduced after Roux-en-Y gastric bypass. Am J Clin Nutr 2009, 90(3): 527–32.

    Article  PubMed  CAS  Google Scholar 

  24. Avgerinos DV, Llaguna OH, Seigerman M, et al.: Incidence and risk factors for the development of anemia following gastric bypass surgery. World J Gastroenterol 2010, 16(15): 1867–70.

    Article  PubMed  CAS  Google Scholar 

  25. Bal B, Koch TR, Finelli FC, Sarr MG.: Management of medical and surgical disorders after divided Roux-en-Y gastric bypass surgery. Nat Rev Gastroenterol Hepatol 2010, 7(6): 320–334.

    PubMed  Google Scholar 

  26. Iannelli A, Addeo P, Novellas S, et al.: Wernicke’s encephalopathy after laparoscopic Roux-en-Y gastric bypass: a misdiagnosed complication. Obes Surg 2010, 20(11): 1594–6.

    Article  PubMed  Google Scholar 

  27. Sebastian JL, V JM, Tang LW, et al.: Thiamine deficiency in a gastric bypass patient leading to acute neurologic compromise after plastic surgery. Surg Obes Relat Dis 2010, 6(1): 105–6.

    Article  PubMed  Google Scholar 

  28. • Francini-Pesenti F, Brocadello F, et al.: Wernicke’s syndrome during parenteral feeding: not an unusual complication. Nutrition 2009, 25(2): 142–6. The authors discuss the potential effects of parenteral feedings on the development of thiamine deficiency. This question of consumption may be very important in patients after gastric bypass surgery in whom parenteral nutrition is being considered for potential protein-calorie malnutrition.

    Article  PubMed  Google Scholar 

  29. • Paparrigopoulos T, Tzavelas E, Karaiskos D, et al.: Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. In Vivo 2010, 24(2): 231–3. This is a report of improved recovery from Wernicke’s syndrome by using high-dose oral thiamine (600 mg/day) and intramuscular thiamine (300 mg/day) for 2 months.

    PubMed  Google Scholar 

Download references

Disclosure

No potential conflicts of interest relevant to this article were reported.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Timothy R. Koch.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bal, B.S., Finelli, F.C. & Koch, T.R. Origins of and Recognition of Micronutrient Deficiencies After Gastric Bypass Surgery. Curr Diab Rep 11, 136–141 (2011). https://doi.org/10.1007/s11892-010-0169-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11892-010-0169-4

Keywords

Navigation