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Migraine and the Risk for Stroke and Cardiovascular Disease

  • Stroke (AB Singhal, Section Editor)
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Abstract

Numerous data have pointed to an association between migraine and cardiovascular diseases. The majority of the available data have indicated that migraine with aura can be considered a risk factor for ischemic stroke, whereas migraine without aura cannot be reliably considered as such. High frequency of attacks and a recent onset of migraine have been related to an increased ischemic stroke risk. In addition, in young subjects with ischemic stroke migraine with aura represents an independent risk factor of overall recurrent vascular events and of recurrent ischemic stroke. Also the risk of transient ischemic attack seems to be increased in migraineurs, although this issue has not been extensively investigated. Several studies have also addressed the possible association between migraine and hemorrhagic stroke. Although the results of these individual studies were conflicting, their meta-analysis showed that migraine is associated with a 1.5-fold increase in the risk of hemorrhagic stroke (including intracerebral and subarachnoid hemorrhage). Some studies have identified migraine also as a possible risk factor for cardiac vascular events while others have yielded negative results. A meta-analysis did not show an increased risk of myocardial infarction in subjects with any migraine vs no migraine but subsequently, data has pointed to an association between any migraine with cardiac ischemic disease. Migraine has also been associated by some studies with vascular mortality and with vascular diseases in regions other than the brain and the heart. Several studies have also indicated that compared with nonmigraineurs, migraineurs have a higher burden of asymptomatic white matter brain lesions and, according to some studies, also infarct-like lesions at brain magnetic resonance. The mechanisms underlying the relationship between migraine and cardiovascular disease are still unclear. The possible explanation may rely on a peculiar vascular vulnerability of migraineurs that may contribute to the pathogenesis of migraine and, in the presence of some other unknown factors may also contribute, over time, to the development of cardiovascular disease. At the moment, there are no reliable features that may indicate which subjects, across the overall migraine population, will develop vascular events and so far, no drugs are recommended for the vascular prevention in migraineurs unless other clear indications are present. In general, the acute treatment and the secondary prevention measures of a patient with stroke who has a history of migraine do not differ from that of other stroke patients. There is currently no direct evidence to support that a migraine prophylactic treatment will reduce future stroke risk in secondary prevention.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Collaborative Group for the Study of Stroke in Young Women. Oral contraceptives and stroke in young women: associated risk factors. JAMA. 1975;231:718–22.

    Article  Google Scholar 

  2. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease: a population-based study. Neurology. 2010;74:628–35.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Buring JE, Hebert P, Romero J, Kittross A, Cook N, Manson J, et al. Migraine and subsequent risk of stroke in the Physicians' Health Study. Arch Neurol. 1995;52:129–34.

    Article  CAS  PubMed  Google Scholar 

  4. Carolei A, Marini C, De Matteis G. History of migraine and risk of cerebral ischaemia in young adults. The Italian National Research Council Study Group on Stroke in the Young. Lancet. 1996;347:1503–6.

    Article  CAS  PubMed  Google Scholar 

  5. Chang CL, Donaghy M, Poulter N. Migraine and stroke in young women: case-control study. The World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. BMJ. 1999;318:13–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Donaghy M, Chang CL, Poulter N. On behalf of the European Collaborators of The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry. 2002;73:747–50.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Hall GC, Brown MM, Mo J, MacRae KD. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology. 2004;62:563–8.

    Article  CAS  PubMed  Google Scholar 

  8. Henrich JB, Horwitz RI. A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol. 1989;42:773–80.

    Article  CAS  PubMed  Google Scholar 

  9. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, et al. Migraine, headache, and the risk of stroke in women: a prospective study. Neurology. 2005;64:1020–6.

    Article  CAS  PubMed  Google Scholar 

  10. MacClellan LR, Giles W, Cole J, et al. Probable migraine with visual aura and risk of ischemic stroke: the Stroke Prevention in Young Women Study. Stroke. 2007;38:2438–45.

    Article  PubMed  Google Scholar 

  11. Tzourio C, Iglesias S, Hubert JB, et al. Migraine and risk of ischaemic stroke: a case-control study. BMJ. 1993;307:289–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Tzourio C, Tehindrazanarivelo A, Iglésias S, et al. Case-control study of migraine and risk of ischaemic stroke in young women. BMJ. 1995;310:830–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Stang PE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, et al. Headache, cerebrovascular symptoms, and stroke: the Atherosclerosis Risk in Communities Study. Neurology. 2005;64:1573–7.

    Article  CAS  PubMed  Google Scholar 

  14. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ. 2005;330:63.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med. 2010;123:612–24.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology. 2009;73:581–8.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, et al. Migraine and risk of cardiovascular disease in men. Arch Intern Med. 2007;167:795–801.

    Article  PubMed  Google Scholar 

  19. Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ. 2008;337:a636.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Rist PM, Buring JE, Kase CS, Schürks M, Kurth T. Migraine and functional outcome from ischemic cerebral events in women. Circulation. 2010;122:2551–7.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, et al. on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators. Predictors of long-term recurrent vascular events after ischemic stroke at young age: the Italian Project on Stroke in Young Adults. Circulation. 2014; [In press]. This study addresses predictors of recurrent vascular events in young subjects with stroke and shows that migraine with aura is an independent predictor of vascular recurrences.

  22. Carter KN, Anderson N, Jamrozik K, Hankey G, Anderson CS. Australasian co-operative research on subarachnoid haemorrhage study (ACROSS) group. Migraine and risk of subarachnoid haemorrhage: a population-based case-control study. J Clin Neurosci. 2005;12:534–7.

    Article  PubMed  Google Scholar 

  23. Schwartz SM, Petitti DB, Siscovick DS, Longstreth Jr WT, Sidney S, Raghunathan TE, et al. Stroke and use of low-dose oral contraceptives in young women: a pooled analysis of two US studies. Stroke. 1998;29:2277–84.

    Article  CAS  PubMed  Google Scholar 

  24. Kuo CY, Yen MF, Chen LS, et al. Increased risk of hemorrhagic stroke in patients with migraine: a population-based cohort study. PLoS One. 2013;8:e55253.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Kurth T, Kase CS, Schürks M, Tzourio C, Buring JE. Migraine and risk of haemorragic stroke in women: prospective cohort study. BMJ. 2010;341:c3659.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Sacco S, Ornello R, Ripa P, Pistoia F, Carolei A. Migraine and hemorrhagic stroke: a meta-analysis. Stroke. 2013;44:3032–8. This meta-analysis provides a summary of studies addressing the relationship between migraine with hemorrhagic stroke.

    Article  PubMed  Google Scholar 

  27. Mitchell P, Wang JJ, Currie J, Cumming RG, Smith W. Prevalence and vascular associations with migraine in older Australians. Aust N Z J Med. 1998;28:627–32.

    Article  CAS  PubMed  Google Scholar 

  28. Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE. Migraine and risk of cardiovascular disease in women. JAMA. 2006;296:283–91.

    Article  CAS  PubMed  Google Scholar 

  29. Sternfeld B, Stang P, Sidney S. Relationship of migraine headaches to experience of chest pain and subsequent risk for myocardial infarction. Neurology. 1995;45:2135–42.

    Article  CAS  PubMed  Google Scholar 

  30. Velentgas P, Cole JA, Mo J, Sikes CR, Walker AM. Severe vascular events in migraine patients. Headache. 2004;44:642–51.

    Article  PubMed  Google Scholar 

  31. Wang YC, Lin CW, Ho YT, Huang YP, Pan SL. Increased risk of ischemic heart disease in young patients with migraine: a population-based, propensity score-matched, longitudinal follow-up study. Int J Cardiol. 2014;172:213–6.

    Article  PubMed  Google Scholar 

  32. Schürks M, Rist PM, Shapiro RE, Kurth T. Migraine and mortality: a systematic review and meta-analysis. Cephalalgia. 2011;31:1301–14.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Gudmundsson LS, Scher AI, Aspelund T, Eliasson JH, Johannsson M, Thorgeirsson G, et al. Migraine with aura and risk of cardiovascular and all-cause mortality in men and women: prospective cohort study. BMJ. 2010;341:c3966.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Rose KM, Carson AP, Sanford CP, et al. Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology. 2004;63:2233–9.

    Article  CAS  PubMed  Google Scholar 

  35. Ikeda K, Hirayama T, Iwamoto K, Takazawa T, Kawase Y, Yoshii Y, et al. Pulse wave velocity study in middle-aged migraineurs at low cardiovascular disease risk. Headache. 2011;51:1239–44.

    Article  PubMed  Google Scholar 

  36. Jurno ME, Chevtchouk L, Nunes AA, de Rezende DF, Jevoux Cda C, de Souza JA, et al. Ankle-brachial index, a screening for peripheral obstructive arterial disease, and migraine—a controlled study. Headache. 2010;50:626–30.

    Article  PubMed  Google Scholar 

  37. Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR. Migraine and retinal microvascular abnormalities: the Atherosclerosis Risk in Communities Study. Neurology. 2007;68:1694–700.

    Article  CAS  PubMed  Google Scholar 

  38. O’Keeffe S, Tsapatsaris N, Beetham Jr W. Association between Raynaud’s phenomenon and migraine in a random population of hospital employees. J Rheumatol. 1993;20:1187–8.

    PubMed  Google Scholar 

  39. Pal B, Gibson C, Passmore J, Griffiths ID, Dick WC. A study of headaches and migraine in Sjogren’s syndrome and other rheumatic disorders. Ann Rheum Dis. 1989;48:312–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  40. Tietjen GE, Gottwald L, Al-Qasmi MM, Gunda P, Khuder SA. Migraine is associated with livedo reticularis: a prospective study. Headache. 2002;42:263–7.

    Article  PubMed  Google Scholar 

  41. Appenzeller S, Costallat LT. Clinical implications of migraine in systemic lupus erythematosus: relation to cumulative organ damage. Cephalalgia. 2004;24:1024–30.

    Article  CAS  PubMed  Google Scholar 

  42. Bushnell CD, Jamison M, James AH. Migraines during pregnancy linked to stroke and vascular diseases: US population based case-control study. BMJ. 2009;338:b664.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Facchinetti F, Allais G, Nappi RE, D'Amico R, Marozio L, Bertozzi L, et al. Migraine is a risk factor for hypertensive disorders in pregnancy: a prospective cohort study. Cephalalgia. 2009;29:286–92.

    Article  CAS  PubMed  Google Scholar 

  44. Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain. A systematic review and meta-analysis. Neurology. 2013;81:1260–8.

    Article  PubMed  Google Scholar 

  45. Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH, Jack CR, et al. Migraine and white matter hyperintensities. The ARIC MRI study. Neurology. 2013;81:1308–13.

    Article  PubMed  Google Scholar 

  46. Kurth T, Mohamed S, Maillard P, Zhu YC, Chabriat H, Mazoyer B, et al. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study. BMJ. 2011;342:c7357.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Monteith T, Gardener H, Rundek T, Dong C, Yoshita M, Elkind M, et al. Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community. Stroke: The Northern Manhattan Study; 2014 [In press].

    Google Scholar 

  48. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA. 2004;291:427–34.

    Article  CAS  PubMed  Google Scholar 

  49. Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, et al. Structural brain changes in migraine. JAMA. 2012;308:1889–97.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. Rist PM, Dufouil C, Glymour MM, Tzourio C, Kurth T. Migraine and cognitive decline in the population-based EVA study. Cephalalgia. 2011;31:1291–300.

    Article  PubMed Central  PubMed  Google Scholar 

  51. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Infarcts in the posterior circulation territory in migraine: the population-based MRI CAMERA study. Brain. 2005;128:2068–77.

    Article  PubMed  Google Scholar 

  52. Scher AI, Gudmundsson LS, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, et al. Migraine headache in middle age and late-life brain infarct. JAMA. 2009;301:2563–70.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  53. Bogousslavsky J, Regli F, Van Melle G, Payot M, Uske A. Migraine stroke. Neurology. 1988;38:223–7.

    Article  CAS  PubMed  Google Scholar 

  54. Broderick JP, Swanson JW. Migraine-related strokes: clinical profile and prognosis in 20 patients. Arch Neurol. 1987;44:868–71.

    Article  CAS  PubMed  Google Scholar 

  55. Caplan LR. Migraine and vertebrobasilar ischemia. Neurology. 1991;41:55–61.

    Article  CAS  PubMed  Google Scholar 

  56. Milhaud D, Bogousslavsky J, van Melle G, Liot P. Ischemic stroke and active migraine. Neurology. 2001;57:1805–11.

    Article  CAS  PubMed  Google Scholar 

  57. Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB. Migraine and cardiovascular disease: possible mechanisms of interaction. Neurology. 2009;72:1864–71.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  58. Kurth T, Chabriat H, Bousser MG. Migraine and stroke: a complex association with clinical implications. Lancet Neurol. 2012;11:92–100.

    Article  PubMed  Google Scholar 

  59. Sacco S, Olivieri L, Bastianello S, Carolei A. Comorbid neuropathologies in migraine. J Headache Pain. 2006;7:222–30.

    Article  PubMed Central  PubMed  Google Scholar 

  60. Sacco S, Cerone D, Carolei A. Comorbid neuropathologies in migraine: an update on cerebrovascular and cardiovascular aspects. J Headache Pain. 2008;9:237–48.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Pietrobon D, Moskowitz MA. Pathophysiology of migraine. Annu Rev Physiol. 2013;75:365–91.

    Article  CAS  PubMed  Google Scholar 

  62. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468:232–43.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  63. Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol. 1983;13:633–41.

    Article  CAS  PubMed  Google Scholar 

  64. Dreier JP, Kleeberg J, Petzold G, Priller J, Windmüller O, Orzechowski HD, et al. Endothelin-1 potently induces Leão’s cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain. 2002;125:102–12.

    Article  PubMed  Google Scholar 

  65. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann-Haerter K, Liu C, et al. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol. 2010;67:221–9.

    Article  PubMed Central  PubMed  Google Scholar 

  66. Sacco S, Ripa P, Grassi D, Pistoia F, Ornello R, Carolei A, et al. Peripheral vascular dysfunction in migraine: a review. J Headache Pain. 2013;14:80.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Sacco S, Degan D, Carolei A. Diagnostic criteria for CADASIL in the International Classification of Headache Disorders (ICHDII): are they appropriate? J Headache Pain. 2010;11:181–6.

    Article  PubMed Central  PubMed  Google Scholar 

  68. Sacco S, Ripa P, Carolei A. Migraine attributed to genetic disorder: proposal of a new category. Cephalalgia. 2011;31:760–2.

    Article  PubMed  Google Scholar 

  69. Wessman M, Terwindt GM, Kaunisto MA, Palotie A, Ophoff RA. Migraine: a complex genetic disorder. Lancet Neurol. 2007;6:521–32.

    Article  CAS  PubMed  Google Scholar 

  70. Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke. 2005;36:1053–8.

    Article  PubMed  Google Scholar 

  71. Lee JH, Eikermann-Haerter K, Joutel A, Moskowitz MA, Ayata C. Enlarged infarcts in mice expressing the archetypal NOTCH3 R90C CADASIL mutation. J Cereb Blood Flow Metab. 2009;29:S253–4.

    Article  Google Scholar 

  72. Eikermann-Haerter K, Lee JH, Yuzawa I, et al. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation. 2012;125:335–45.

    Article  PubMed Central  PubMed  Google Scholar 

  73. Chen TC, Leviton A, Edelstein S, Ellenberg JH. Migraine and other diseases in women of reproductive age. The influence of smoking on observed associations. Arch Neurol. 1987;44:1024–8.

    Article  CAS  PubMed  Google Scholar 

  74. Sacco S, Ricci S, Carolei A. Migraine and vascular diseases: potential implications for management. Cephalalgia. 2012;32:785–95.

    Article  PubMed  Google Scholar 

  75. Davis D, Gregson J, Willeit P, Stephan B, Al-Shahi Salman R, et al. Patent foramen ovale, ischemic stroke and migraine: systematic review and stratified meta-analysis of association studies. Neuroepidemiology. 2013;40:56–67.

    Article  PubMed  Google Scholar 

  76. Kurth T, Diener HC. Migraine and stroke: perspectives for stroke physicians. Stroke. 2012;43:3421–6.

    Article  PubMed  Google Scholar 

  77. Sacco S, Carolei A. Is migraine a modifiable risk factor for ischemic stroke? Potentially not. Am J Med. 2011;124:e9.

    Article  PubMed  Google Scholar 

  78. Diener HC, Gendolla A, Feuersenger A, Evers S, Straube A, Schumacher H, et al. Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial. Cephalalgia. 2009;29:921–7.

    Article  CAS  PubMed  Google Scholar 

  79. Schrader H, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomised, placebo controlled, crossover study. BMJ. 2001;322:19–22.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  80. Stovner LJ, Linde M, Gravdahl GB, Tronvik E, Aamodt AH, Sand T, et al. A comparative study of candesartan vs propranolol for migraine prophylaxis: a randomized, triple-blind, placebo- controlled, double cross-over study. Cephalalgia. 2014; [In press].

  81. Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G. Prophylactic treatment of migraine with an angiotensin II receptor blocker: a randomized controlled trial. JAMA. 2003;289:65–9.

    Article  CAS  PubMed  Google Scholar 

  82. Dahlöf B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, et al. LIFE Study Group. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomized trial against atenolol. Lancet. 2002;359:995–1003.

    Article  PubMed  Google Scholar 

  83. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:145–53.

    Article  CAS  PubMed  Google Scholar 

  84. der Wammes-van Heijden EA, Rahimtoola H, Leufkens HG, Tijssen CC, Egberts AC. Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology. 2006;67:1128–34.

    Article  Google Scholar 

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Simona Sacco and Tobias Kurth declare that they have no conflict of interest.

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  1. Department of Biotechnological and Applied Clinical Sciences, Division of Clinical Neurology, University of L’Aquila, 67100, L’Aquila, Italy

    Simona Sacco

  2. Inserm Research Center for Epidemiology and Biostatistics (U897), Team Neuroepidemiology, University of Bordeaux, Bordeaux, France

    Tobias Kurth

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Correspondence to Simona Sacco.

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Sacco, S., Kurth, T. Migraine and the Risk for Stroke and Cardiovascular Disease. Curr Cardiol Rep 16, 524 (2014). https://doi.org/10.1007/s11886-014-0524-1

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