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Proteomic and Metabolomic Profiles in Atherothrombotic Vascular Disease

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Abstract

Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell death, and extracellular matrix breakdown. The complex biological multifactorial nature of atherothrombosis requires the development of novel technologies that allow the analysis of cellular and molecular processes responsible for the transition to disease phenotypes and the discovery of new diagnostic and prognostic biomarkers. In the present article, we have reviewed recent advances in the application of proteomic and metabolomic techniques to the study of atherothrombosis. We have focused on recent studies analyzing cells involved in hemo-thrombus formation (platelets, red blood cells, and polymorphonuclear cells), as well as tissues, tissue-conditioned media, and plasma of atherothrombotic patients. In the future, the application of these high-throughput technologies, along with imaging techniques, in systems biology approaches will help to individualize medicine.

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Acknowledgments

The papers from the authors cited in the present review have been supported by European Network (HEALTH F2-2008-200647), SAF 2007/63648, SAF2007/60896, CAM (S2006/GEN-0247), Fundación Ramón Areces, Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Red RECAVA (RD06/0014/0035), Fondo de Investigaciones Sanitarias (Programa Miguel Servet to L.M.B-C). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by MICINN and Pro CNIC Foundation.

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No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Vascular Research Laboratory, Instituto de Investigacion Sanitaria, Fundación Jimenez Diaz, Autonoma University, Av. Reyes Católicos 2, 28040, Madrid, Spain

    Roxana Martinez-Pinna, Luis Miguel Blanco-Colio, Priscila Ramos-Mozo, Jesus Egido & José Luis Martin-Ventura

  2. Pharmacy Faculty, Campus Monteprincipe, San Pablo-CEU University, 28668 Boadilla del Monte, Madrid, Spain

    Coral Barbas

  3. Department of Cardiology, Instituto de Investigaciones Sanitarias, Fundación Jimenez Diaz, Autonoma University, Av. Reyes Católicos 2, 28040, Madrid, Spain

    Jose Tunon

  4. Unidad de Proteomica, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

    Juan Antonio Lopez

  5. Inserm, U698, Univ Paris 7, CHU X-Bichat, Paris, France

    Olivier Meilhac & Jean-Baptiste Michel

Authors
  1. Roxana Martinez-Pinna
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  2. Coral Barbas
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  3. Luis Miguel Blanco-Colio
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  4. Jose Tunon
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  5. Priscila Ramos-Mozo
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  8. Jean-Baptiste Michel
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  9. Jesus Egido
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  10. José Luis Martin-Ventura
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Corresponding author

Correspondence to José Luis Martin-Ventura.

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Martinez-Pinna, R., Barbas, C., Blanco-Colio, L.M. et al. Proteomic and Metabolomic Profiles in Atherothrombotic Vascular Disease. Curr Atheroscler Rep 12, 202–208 (2010). https://doi.org/10.1007/s11883-010-0102-y

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