Abstract
Transient ischemic attack (TIA) represents one end of the spectrum of focal brain ischemia, the other being completed infarction or ischemic stroke. The evolving technologic advancements in neuroimaging continue to change and sharpen the definition, epidemiology, and management of TIA. As a powerful risk factor for ischemic stroke, TIA deserves widespread public and physician education, urgent attention and investigation, and rapid management. The recognition and treatment of TIA provides an excellent opportunity for stroke prevention that is often missed or poorly recognized among physicians.
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References and Recommended Reading
Johnston SC: Transient ischemic attack. N Engl J Med 2002, 347:1687–1692.
Kidwell CS, Alger JR, Salle FD, et al.: Diffusion MRI in patients with transient ischemic attacks. Stroke 1999, 30:1174–1180.
Rovira A, Rovira-Gols A, Pedraza S, et al.: Diffusion-weighted MR imaging in the acute phase of transient ischemic attacks. Am J Neuroradiol 2002, 23:77–83.
Albers GW, Caplan LR, Easton JD, et al.: Transient ischemic attack—proposal for a new definition. N Engl J Med 2002, 347:1713–1716.
Ovbiagele B, Kidwell CS, Saver JL: Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack. Stroke 2003, 34:919–924.
Johnston SC, Fayad PB, Gorelick PB, et al.: Prevalence and knowledge of transient ischemic attack among US adults. Neurology 2003, 60:1429–1434.
Nguyen-Huynh MN, Fayad P, Gorelick PB, Johnston SC: Knowledge and management of transient ischemic attacks among US primary care physicians. Neurology 2003, 61:1455–1456.
Goldstein LB, Bian J, Samsa GP, et al.: New transient ischemic attack and stroke: outpatient management by primary care physicians. Arch Intern Med 2000, 160:2941–2946.
Volpato S, Maraldi C, Ble A, et al.: Prescription of antithrombotic therapy in older patients hospitalized for transient ischemic attack and ischemic stroke: the GIFA Study. Stroke 2004, 35:913–917.
Lisabeth LD, Ireland JK, Risser JM, et al.: Stroke risk after transient ischemic attack in a population-based setting. Stroke 2004, 35:1842–1846.
Gladstone DJ, Kapral MK, Fang J, et al.: Management and outcomes of transient ischemic attacks in Ontario. Can Med Assoc J 2004, 170:1099–1104.
Edlow JA, Kim S: US emergency department visits for transient ischemic attack, 1992–2000. Acad Emerg Med 2003, 5:432.
Rothwell PM, Coull AJ, Giles MF, et al.: Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2002. Lancet 2004, 363:1925–1933.
Whisnant JP, Brown RD, Petty GW, et al.: Comparison of population-based models of risk factors for TIA and ischemic stroke. Neurology 1999, 53:532–536.
Dijk JM, van der Graaf Y, Grobbee DE, et al.: Carotid stiffness indicates risk of ischemic stroke and TIA in patients with internal carotid artery stenosis. The SMART study. Stroke 2004, 35:2258–2262.
Sacco RL: Risk factors for TIA and TIA as a risk factor for stroke. Neurology 2004, 62:S7-S11.
Johnston SC, Gress DR, Browner WS, Sidney S: Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000, 284:2901–2906.
Lovett JK, Dennis MS, Sandercock PA, et al.: Very early risk of stroke after a first transient ischemic attack. Stroke 2003, 34:e138-e142.
Panagos PD, Pancioli AM, Khoury J, et al.: Short-term prognosis after emergency department diagnosis and evaluation of transient ischemic attack (TIA). Acad Emerg Med 2003, 10:432–433.
Hill MD, Yiannakoulias N, Jeerakathil T, et al.: The high risk of stroke immediately after transient ischemic attack. Neurology 2004, 62:2015–2020.
Johnston SC, Easton JD: Are patients with acutely recovered cerebral ischemia more unstable? Stroke 2003, 34:2446–2452.
Barber PA, Zhang J, Demchuck AM, et al.: Why are stroke patients excluded from TPA therapy? Neurology 2001, 56:1015–1020.
Benavente O, Eliasziw M, Streifler JY, et al.: Prognosis after transient monocular blindness associated with carotid artery stenosis. N Engl J Med 2001, 345:1084–1090.
Johnston SC, Sidney S, Bernstein AL, et al.: A comparison of risk factors for recurrent TIA and stroke in patients diagnosed with TIA. Neurology 2003, 60:280–285.
Hart RG, Pearce LA, Koudstaal PJ: Transient ischemic attacks in patients with atrial fibrillation. Stroke 2004, 35:948–951.
Herve D, Gautier-Bertrand M, Labreuche J, Amarenco P: Predictive value of lacunar transient ischemic attacks. Stroke 2004, 35:1430–1435.
Eliasziw M, Kennedy J, Hill MD, et al.: Early stroke risk after a transient ischemic attack in patients with internal carotid artery disease. Can Med Assoc J 2004, 170:1105–1109.
Rothwell PM, Eliasziw M, Gutknikov SA, et al.: Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004, 363:915–924.
Douglas VC, Johnston CM, Elkins J, et al.: Head computed tomography findings predict short-term stroke risk after transient ischemic attack. Stroke 2003, 34:2894–2899.
Crisostomo RA, Garcia MM, Tong DC: Detection of diffusion-weighted MRI abnormalities in patients with transient ischemic attack: correlation with clinical characteristics. Stroke 2003, 34:932–937.
Inatomi Y, Kimura K, Yonehara et al.: DWI abnormalities and clinical characteristics in TIA patients. Neurology 2004, 62:376–380.
Winbeck K, Bruckmaier K, Etgen T, et al.: Transient ischemic attack and stroke can be differentiated by analyzing early diffusion-weighted imaging signal intensity changes. Stroke 2004, 35:1095–1099.
Restrepo L, Jacobs MA, Barker PB, et al.: Assessment of transient ischemic attack with diffusion- and perfusion-weighted imaging. Am J Neuroradiol 2004, 25:1645–1652.
Sitzer M, Foerch C, Neumann-Haefelin T, et al.: Transient ischemic attack preceding anterior circulation infarction is independently associated with favorable outcome. J Neurol Neurosurg Psychiatry 2004, 75:659–660.
Wegener S, Gottschalk B, Jovanovic V, et al.: Transient ischemic attacks before ischemic stroke: preconditioning the human brain? A multi-center magnetic resonance study. Stroke 2004, 35:616–621.
Johnston SC: Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA study. Stroke 2004, 35:2680–2682.
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Liberato, B., Prabhakaran, S. & Sacco, R.L. Evolving concepts regarding transient ischemic attacks. Curr Atheroscler Rep 7, 274–279 (2005). https://doi.org/10.1007/s11883-005-0019-z
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DOI: https://doi.org/10.1007/s11883-005-0019-z