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Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

  • Asthma (V Ortega, Section Editor)
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Abstract

Purpose of Review

Bronchial asthma is a common respiratory disease induced by immune imbalance, characterized by chronic non-specific airway inflammation and airway hyperresponsiveness (AHR). Many factors induce asthma, among which respiratory infection is the important cause. In this review, we discuss how respiratory microbes participate in the occurrence and progression of asthma via Th17/IL-17 axis.

Recent Findings

Pathogenesis of asthma has been considered as closely related to the imbalance in number and function of Th1/Th2 in the CD4+ T lymphocyte subsets. Recent studies have shown that Th17 cell and its secretory IL-17 also play an important role in AHR. Respiratory virus, bacteria, fungi, and other respiratory microbial infections can directly or indirectly induce the differentiation of Th17 cell and the production of related cytokines to induce AHR.

Summary

Respiratory microbial infection can affect the TH17/IL-17A axis through a variety of mechanisms, thereby promoting the occurrence and development of asthma, and these specific mechanisms may provide new effective therapeutic ideas for asthma.

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Funding

This work was supported by Grant 31670121 and 31771277 from the National Natural Science Foundation of China.

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  1. Department of Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China

    Dan Liu, Yurong Tan, Ousman Bajinka, Lili Wang & Zhongxiang Tang

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Liu, D., Tan, Y., Bajinka, O. et al. Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma. Curr Allergy Asthma Rep 20, 11 (2020). https://doi.org/10.1007/s11882-020-00903-x

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