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Could This Be IT? Epicutaneous, Sublingual, and Subcutaneous Immunotherapy for the Treatment of Food Allergies

  • Food Allergy (E Kim, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Over the last decade, there has been a spark in innovation in the development of therapies for food allergy. Herein, we describe the background and recent advances for food-specific immunotherapies including epicutaneous (EPIT), sublingual (SLIT), and subcutaneous (SCIT).

Recent Findings

Studies have progressed most quickly for the treatment of peanut allergy. Data from the phase 3 EPIT trial add to the accumulating evidence that this will be a viable therapy for peanut allergy. Studies for SLIT and SCIT remain in earlier phases with promising results.

Summary

This is an exciting era for the treatment of food allergy. Multiple therapies are under investigation, each with their own potential advantages. Specific strengths and limitations of each of these therapies may provide an opportunity to personalize the choice of therapy for individual patients.

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Abbreviations

APC:

Antigen-presenting cell

DBPCFC:

Double-blind, placebo-controlled food challenge

ED:

Eliciting dose

EPIT:

Epicutaneous immunotherapy

EVP:

Epicutaneous Viaskin® Patch

IgE:

Immunoglobulin E

IgG4 :

Immunoglobulin G4

IT:

Immunotherapy

OIT:

Oral immunotherapy

SCIT:

Subcutaneous immunotherapy

SLIT:

Sublingual immunotherapy

TH1:

T helper cell type 1

TH2:

T helper cell type 2

Treg:

T regulatory cell

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Division of Pediatric Allergy & Immunology, Department of Pediatrics, Elliot and Roslyn Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1198, New York, NY, 10029, USA

    Mary Grace Baker & Julie Wang

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Correspondence to Julie Wang.

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Conflict of Interest

Dr. Wang received research support from NIAID, Aimmune, DBV Therapeutics, Regeneron; consultancy fees from ALK Abello and DBV Technologies; and royalties from UpToDate.

Dr. Baker was supported in part by the Louis and Rachel Rudin Foundation.

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Baker, M.G., Wang, J. Could This Be IT? Epicutaneous, Sublingual, and Subcutaneous Immunotherapy for the Treatment of Food Allergies. Curr Allergy Asthma Rep 19, 53 (2019). https://doi.org/10.1007/s11882-019-0885-z

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