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Immunology and Clinical Manifestations of Non-Clonal Mast Cell Activation Syndrome

  • BASIC AND APPLIED SCIENCE (M FRIERI, SECTION EDITOR)
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Abstract

There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.

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Authors and Affiliations

  1. Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Juan-Carlos Cardet & Mariana C. Castells

  2. Division of Gastroenterology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Matthew J. Hamilton

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  1. Juan-Carlos Cardet
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Correspondence to Matthew J. Hamilton.

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Cardet, JC., Castells, M.C. & Hamilton, M.J. Immunology and Clinical Manifestations of Non-Clonal Mast Cell Activation Syndrome. Curr Allergy Asthma Rep 13, 10–18 (2013). https://doi.org/10.1007/s11882-012-0326-8

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