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Respiratory deposition and health risk of inhalation of particle-bound heavy metals in the carbon black feeding area of a tire manufacturer

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Abstract

The health effects of metal-containing carbon black (CB) particles obtained from the CB feeding area of a tire manufacturing plant were investigated. Atmospheric samples were collected over 24 h for 20 working days in 2016 using the 12 impaction stages of micro-orifice uniform deposit impactor, and metal-containing particles were analyzed using an inductively coupled plasma optical emission spectrometer. The concentration of total particulate matter in the CB feeding area was 944.8 ± 456.4 μg/m3, and the most abundant elements in the samples include Zn (8622.0 ± 5679.0 ng/m3), Al (3113.3 ± 2017.1 ng/m3), and Fe (1519.1 ± 875.0 ng/m3). Carcinogenic metals (Cd, Co, Cr, and Ni) with the mass median diameter were incorporated in submicron particles. The mean total deposition flux in the head airway (HA) region was approximately 16–30 times higher than that in the tracheobronchial (TB) region and alveolar region (AR). The most abundant deposition flux of heavy metals in the AR and TB region was distributed in particles of less than 3.2 μm. The cancer risk presented by carcinogenic metals (Cd, Co, Cr, and Ni) in total particles to CB feeding workers ranged from 5.52 × 10−4 to 5.65 × 10−2, which is substantially higher than the acceptable cancer risk range 10−6–10−4. In particular, the cancer risk presented by these four metals in ultrafine particles (UFPs) exceeded the 10−6 benchmark level. These results demonstrate the high health risk presented by particle-bound heavy metals to workers in a CB feeding area via inhalation exposure.

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References

  • Araujo JA (2011) Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual Atmos Health 4:79–93

    Article  Google Scholar 

  • Auchter JF (2005) Chemical economics handbook: carbon black. SRI Consulting, Menlo Park

    Google Scholar 

  • Boysen M, Solberg L, Torjussen W, Poppe S, Høgetveit A (1984) Histological changes, rhinoscopical findings and nickel concentration in plasma and urine in retired nickel workers. Acta Otolaryngol 97:105–115

    Article  CAS  Google Scholar 

  • Brown JS, Gordon T, Price O, Asgharian B (2013) Thoracic and respirable particle definitions for human health risk assessment. Part Fibre Toxicol 10:12

    Article  Google Scholar 

  • Chiang YC, Yang HJ, Chen SC, Hu CW, Tsai CT, Lai DJ, Kuo CT (2017) Inhalation exposure of children to indoor PM10 and associated metals during river-dust episodes. Air Qual Atmos Health 10:381–388

    Article  CAS  Google Scholar 

  • Chuang KY, Lai CH, Peng YP, Yen TY (2015) Characteristics of particle-bound polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in atmosphere used in carbon black feeding process at a tire manufacturing plant. Environ Sci Pollut R 22:19451–19460

    Article  CAS  Google Scholar 

  • Collyer HJ (1975) Carbon black and ecology. In: Ayer FA (ed) Environmental aspects of chemical use in rubber processing operations, March 1975, Akron, OH (EPA-560/1–75–002; PB244 172). Environmental Protection Agency, Washington DC, pp 130–136

    Google Scholar 

  • Dockery DW, Pope CA (1994) Acute respiratory effects of particulate air pollution. Annu Rev Public Health 15:107–132

    Article  CAS  Google Scholar 

  • Donaldson K, Brown D, Clouter A, Duffin R, MacNee W, Renwick L, Tran L, Stone V (2002) The pulmonary toxicology of ultrafine particles. J Aerosol Med 15:213–220

    Article  CAS  Google Scholar 

  • Dutta A, Ray MR (2013) Increased cardiovascular risk due to systemic inflammatory changes and enhanced oxidative stress in urban Indian women. Air Qual Atmos Health 6:501–508

    Article  Google Scholar 

  • Gao B, Zhou H, Yu Y, Wang Y (2015) Occurrence, distribution, and risk assessment of the metals in sediments and fish from the largest reservoir in China. RSC Adv 5:60322–60329

    Article  CAS  Google Scholar 

  • Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Hof VI, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113(11):1555–1560

    Article  Google Scholar 

  • Gray CA, Muranko H (2006) Studies of robustness of industrial aciniform aggregates and agglomerates—carbon black and amorphous silicas: a review amplified by new data. J Occup Environ Med 48(12):1279–1290

    Article  CAS  Google Scholar 

  • Harrad S, Wijesekera R, Hunter S, Halliwell C, Baker R (2004) Preliminary assessment of UK human dietary and inhalation exposure to polybrominated diphenyl ethers. Environ Sci Technol 38(8):2345–2350

    Article  CAS  Google Scholar 

  • Heys KA, Shore RF, Pereira MG, Jones KC, Martin FL (2016) Risk assessment of environmental mixture effects. RSC Adv 6:47844–47857

    Article  CAS  Google Scholar 

  • Hinds WC (1999) Aerosol technology: properties, behavior, and measurement of airborne particles. Wiley Interscience, New York

    Google Scholar 

  • Hlavay J, Polyák K, Wesemann G (1992) Particle size distribution of mineral phases and metals in dusts collected at different workplaces. Fresenius J Anal Chem 344(7–8):319–321

    Article  CAS  Google Scholar 

  • Huang CL, Bao LJ, Luo P, Wang ZY, Li SM, Zeng EY (2016) Potential health risk for residents around a typical e-waste recycling zone via inhalation of size-fractionated particle-bound heavy metals. J Hazard Mater 317:449–456

    Article  CAS  Google Scholar 

  • IARC (International Agency for Research on Cancer) (1990) IARC monographs on the evaluation of carcinogenic risk of chemicals to man, vol 49, chromium, nickel and welding. IARCPress, Lyon, p 298

    Google Scholar 

  • ICRP (International Commission on Radiological Protection) (1994) Publication 66: human respiratory tract model for radiological protect. Annal of the ICRP 24:1–3

    Google Scholar 

  • Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182

    Article  Google Scholar 

  • Kuhlbusch T, Fissan H (2006) Particle characteristics in the reactor and pelletizing areas of carbon black production. J Occup Environ Hyg 3(10):558–567

    Article  CAS  Google Scholar 

  • Kuhlbusch T, Neumann S, Fissan H (2004) Number size distribution, mass concentration, and particle composition of PM1, PM2.5, and PM10 in bag filling areas of carbon black production. J Occup Environ Hyg 1(10):660–671

    Article  CAS  Google Scholar 

  • Lai CH, Yan TY (2016) Characteristics and aerosol size distributions of metal-containing paint particles at a spray-painting workplace. RSC Adv 6:113754–113761

    Article  CAS  Google Scholar 

  • Latif MT, Yong SM, Saad A, Mohamad N, Baharudin NH, Mokhtar MB, Tahir NM (2014) Composition of heavy metals in indoor dust and their possible exposure: a case study of preschool children in Malaysia. Air Qual Atmos Health 7:181–193

    Article  CAS  Google Scholar 

  • Lippmann M (2011) Regional deposition of particles in the human respiratory tract. Compr Physiol. https://doi.org/10.1002/cphy.cp090114

  • Lyu Y, Zhang K, Chai F, Cheng T, Yang Q, Zheng Z, Li X (2017) Atmospheric size-resolved trace elements in a city affected by non-ferrous metal smelting: indications of respiratory deposition and health risk. Environ Pollut 224:559–571

    Article  Google Scholar 

  • MEA–Department of Statistics, Ministry of Economic Affairs (2016) Yearbook of Industrial Production Statistics, Republic of China Available at: http://www.moea.gov.tw/Mns/dos/content/ContentLink.aspx?menu_id=9426. Accessed 2 May 2017

  • Nagar JK, Akolkar A, Kumar R (2014) A review on airborne particulate matter and its sources, chemical composition and impact on human respiratory system. Int J Environ Sci 5(2):447–463

    Google Scholar 

  • Nouwen J, Cornelis C, De Fre R, Wevers M, Viaene P, Mensink C, Patyn J, Verschaeve L, Hooghe R, Maes A (2001) Health risk assessment of dioxin emissions from municipal waste incinerators: the Neerlandquarter (Wilrijk, Belgium). Chemosphere 43(4–7):909–923

    Article  CAS  Google Scholar 

  • Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16(6–7):437–445

    Article  Google Scholar 

  • Poland CA, Clife MJD (2013) Nanoparticle-lung interactions and their potential consequences for human health, in bio-nanotechnology: a revolution in food, biomedical and health science, Blackwell Publishing Ltd., Oxford. https://doi.org/10.1002/9781118451915.ch43

  • Rodriguez-Espinosa PF, Flores-Rangel RM, Mugica-Alvarez V, Morales-Garcia SS (2017) Sources of trace metals in PM10 from a petrochemical industrial complex in Northern Mexico. Air Qual Atmos Health 10:69–84

    Article  CAS  Google Scholar 

  • Schins RP, Knaapen AM (2007) Genotoxicity of poorly soluble particles. Inhal Toxicol 19:189–198. https://doi.org/10.1080/08958370701496202

    Article  CAS  Google Scholar 

  • Seilkop SK, Oller AR (2003) Respiratory cancer risks associated with low-level nickel exposure: an integrated assessment based on animal, epidemiological, and mechanistic data. Regul Toxicol Pharmacol 37(2):173–190

    Article  CAS  Google Scholar 

  • Simkhovich BZ, Kleinman MT, Willet P, Gookin G, Salazar K, Keebaugh A, Kloner R (2011) Chronically inhaled ambient particles cause cardiac inflammation in normal, diseased, and elderly rat hearts. Air Qual Atmos Health 4:27–36

    Article  Google Scholar 

  • Sunderman FW (2001) Nasal toxicity, carcinogenicity, and olfactory uptake of metals. Ann Clin Lab Sci 31(1):3–24

    CAS  Google Scholar 

  • Tsai PJ, Shieh HY, Lee WJ, Chen HL, Shih TS (2002a) Urinary 1-hydroxypyrene as a biomarker of internal dose of polycyclic aromatic hydrocarbons in carbon black workers. Ann Occup Hyg 46(2):229–235

    CAS  Google Scholar 

  • Tsai PJ, Shieh HY, Lee WJ, Lai SO (2002b) Characterization of PAHs in the atmosphere of carbon black manufacturing workplaces. J Hazard Mater 91(1–3):25–42

    Article  CAS  Google Scholar 

  • Tsai JH, Chen SJ, Huang KL, Lin TC, Chaung HC, Chiu CH, Chiu JY, Lin CC, Tsai PY (2012) PM, carbon, PAH, and particle-extract-induced cytotoxicity of emissions from a diesel generator fueled with waste-edible-oil-biodiesel. Aerosol Air Qual Res 12:843–855

    CAS  Google Scholar 

  • US-EPA (2012) Integrated Risk Information System. Available at: http://www.epa.gov/iris. U.S. Environmental Protection Agency; 2012. Accessed 20 May 2016

  • Voll M, Kleinschmit P (2002) Carbon. In: Ullmann’s encyclopedia of industrial chemistry. Wiley-VCH Verlag GmbH & Co, New York

    Google Scholar 

  • Wang MJ, Gray CA, Reznek SA, Mahmud K, Kutsovsky Y (2003) Carbon black. Kirk-Othmer encyclopedia of chemical technology. John Wiley & Sons, Inc. https://doi.org/10.1002/0471238961.0301180204011414.a01.pub2

  • Yan J, Huang CC, Lung SCC, Wang WC, Suo G, Lin YJ, Lai CH, Lin CH (2017a) ROCK inhibitor Y-27632 attenuates early endothelial dysfunction caused by occupational environmental concentrations of carbon black nanoparticles. Environ Sci-Nano. https://doi.org/10.1039/C7EN00123A

  • Yan J, Lai CH, Lung SCC, Wang WC, Huang CC, Chen GW, Suo G, Choug CT, Lin CH (2017b) Carbon black aggregates cause endothelial dysfunction by activating ROCK. J Hazard Mater 338:66–75

    Article  CAS  Google Scholar 

  • Zhang N, Han B, He F, Xu J, Niu C, Zhou J, Kong S, Bai Z, Xu H (2015) Characterization, health risk of heavy metals, and source apportionment of atmospheric PM2.5 to children in summer and winter: an exposure panel study in Tianjin, China. Air Qual Atmos Health 8:347–357

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The author would like to thank the Ministry of Science and Technology (MOST) in Taiwan for the financial support under the Grant No. MOST 105-2221-E-166-002.

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Authors and Affiliations

  1. Department of Safety Health and Environmental Engineering, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Chia-Hsiang Lai & Chang-Chun Liao

  2. Department of Biotechnology, National Formosa University, Yunlin, 63208, Taiwan

    Chia-Hua Lin

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  1. Chia-Hsiang Lai
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Correspondence to Chia-Hsiang Lai.

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Lai, CH., Lin, CH. & Liao, CC. Respiratory deposition and health risk of inhalation of particle-bound heavy metals in the carbon black feeding area of a tire manufacturer. Air Qual Atmos Health 10, 1281–1289 (2017). https://doi.org/10.1007/s11869-017-0515-7

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