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Advances and Future Directions in the Targeting of HER2-positive Breast Cancer: Implications for the Future

  • Breast Cancer (CI Falkson, Section Editor)
  • Published:
Current Treatment Options in Oncology Aims and scope Submit manuscript

Opinion statement

The natural history of HER2-positive breast cancer significantly changed in the past 15 years. Form being the most aggressive type of breast cancer, it became treatable with important cure rates. However, with new and successful drugs, resistance emerges. Progress in research and drug development continues to make available effective anti-HER2 therapies. Our challenge today is to use these tools correctly by looking at the data that support the indications of each compound and to continue clinical trial participation.

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Conflict of Interest

Ishwaria M. Subbiah declares no conflict of interest.

Ana Maria Gonzalez-Angulo has research funding and paid consultancy to Genentech, Novartis and GlaxoSmithKline.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Funding

This work was supported in part by National Cancer Institute 1K23CA121994 (AMG) ASCO Career Development Award (AMG), Komen for the Cure Catalystic Award KG090341 (AMG), American Cancer Society Research Scholar Grant 121329-RSG-11-187-01-TBG (AMG), National Cancer Institute through The University of Texas MD Anderson’s Cancer Center Support Grant (P30 CA016672).

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Authors and Affiliations

  1. Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030-4009, USA

    Ishwaria M. Subbiah MD, MS

  2. Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Unit 1354, 1515 Holcombe Boulevard, Houston, TX, 77030-4009, USA

    Ana Maria Gonzalez-Angulo MD

  3. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030-4009, USA

    Ana Maria Gonzalez-Angulo MD

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  1. Ishwaria M. Subbiah MD, MS
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Correspondence to Ana Maria Gonzalez-Angulo MD.

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Subbiah, I.M., Gonzalez-Angulo, A.M. Advances and Future Directions in the Targeting of HER2-positive Breast Cancer: Implications for the Future. Curr. Treat. Options in Oncol. 15, 41–54 (2014). https://doi.org/10.1007/s11864-013-0262-4

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