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Critically ill newborns with multiple organ dysfunction: assessment by NEOMOD score in a tertiary NICU

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Abstract

Background

The neonatal multiple organ dysfunction score (NEOMOD) predicts mortality during the first 28 days of life, and provides information on organ functions influencing mortality.

Aim

To test the predictive and descriptive accuracy of NEOMOD in very low birth weight (VLBW) infants.

Methods

The system was used in 112 infants. It evaluates the central nervous system (CNS), coagulation, respiratory, gastrointestinal (GIT), cardiovascular (CVS), renal system, and acid–base balance in 24-h intervals during the first 28 days of life.

Results

A NEOMOD of ≥9 was associated with 100% mortality. A receiver operating characteristic (ROC) curve was used for assessing the accuracy of NEOMOD score in prediction of mortality. The area under curve (AUC) attained by NEOMOD was 0.93 for mortality.

Conclusions

The NEOMOD evaluates daily the severity of the multiple organ dysfunction syndrome (MODS) and is an accurate predictor of mortality.

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Author information

Authors and Affiliations

  1. Department of Paediatrics, The Rotunda Hospital, Parnell Square, Dublin 1, Ireland

    J. Janota, T. Matthews, T. Clarke & D. Corcoran

  2. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA

    J. Simak

  3. Institute for Care of Mother and Child, Praha, Czech Republic

    Z. Stranak

  4. The Children’s Hospital, Temple Street, Dublin, Ireland

    T. Matthews, T. Clarke & D. Corcoran

Authors
  1. J. Janota
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  2. J. Simak
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  3. Z. Stranak
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  4. T. Matthews
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  5. T. Clarke
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  6. D. Corcoran
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Corresponding author

Correspondence to J. Janota.

Additional information

Disclaimer: The findings and conclusions in this study have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination or policy.

Appendix

Appendix

Table 7.

Table 7 Criteria established to determine specific organ failures
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Janota, J., Simak, J., Stranak, Z. et al. Critically ill newborns with multiple organ dysfunction: assessment by NEOMOD score in a tertiary NICU. Ir J Med Sci 177, 11–17 (2008). https://doi.org/10.1007/s11845-008-0115-5

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  • DOI: https://doi.org/10.1007/s11845-008-0115-5

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