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Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal oxides

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Abstract

Herein we provide a novel high-efficiency nanocomposite for bacterial capture based on mixed metal oxides (MMOs) with deleterious chromium properties. With both the layer structure of layered double hydroxides (LDHs) and the magnetic properties of Fe, MMOs enrich the location of ionic forms on the surface, providing a good carrier for adsorption of the heavy metal Cr(VI). The capacity for adsorption of Cr(VI) by MMOs can be as high as 98.80 mg/g. The prepared Cr(VI)-MMOs achieved extremely expeditious location of gram-negative antibiotic-resistant E. coliNDM-1 by identifying lipid bilayers. Cr-MMOs with a Cr loading of 19.70 mg/g had the best bactericidal effect, and the concentration of E. coliNDM-1 was decreased from ∼10 to ∼10 CFU/mL after 30 min of reaction. The binding of nitrogen and phosphorus hydrophilic groups to chromate generated realistic models for density functional theory (DFT) calculations. The specific selectivity of MMOs toward bacterial cells was improved by taking Cr(VI) as a transferable medium, thereby enhancing the antibacterial activity of Cr-MMOs. Under the combined action of chemical and physical reactions, Cr(VI)-MMOs achieved high capacity for inactivation of bacteria. Moreover, the metallic elements ratio in Cr-MMOs remained stable in their initial valence states after inactivation. This guaranteed high removal efficiency for both heavy metals and bacteria, allowing recycling of the adsorbent in practical applications.

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Acknowledgements

The authors gratefully acknowledge the financial support by the National Key Research and Development Program of China (No. 2017YFA0207203), and National Natural Science Foundation of China (Grant No. 51978195).

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Authors and Affiliations

  1. State Key Laboratory of Urban Water Resources and Environment (SKLUWRE), Harbin Institute of Technology, Harbin, 150090, China

    Yanlin Li, Lei Zhu, Yixing Yuan & Jun Ma

  2. Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology, School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin, 300384, China

    Bo Wang

  3. Jiangsu Yihuan Group Co., Ltd., Yixing, 214206, China

    Bo Wang

  4. School of Environment, Tsinghua University, Beijing, 100084, China

    Lujun Chen

Authors
  1. Yanlin Li
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  2. Bo Wang
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  3. Lei Zhu
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  4. Yixing Yuan
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  5. Lujun Chen
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  6. Jun Ma
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Corresponding authors

Correspondence to Bo Wang or Jun Ma.

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Highlights

• LDHs and MMOs was synthesized by ultrasound-assisted one-step co-precipitation.

• MMOs performs the best for Cr(VI) and E. coliNDM-1 simultaneous removal.

• Possible antibacterial pathways of Cr-MMOs were proposed.

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Li, Y., Wang, B., Zhu, L. et al. Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal oxides. Front. Environ. Sci. Eng. 16, 68 (2022). https://doi.org/10.1007/s11783-021-1502-7

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  • DOI: https://doi.org/10.1007/s11783-021-1502-7

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