Abstract
I have reviewed recent (March 1995–December 1997) papers on human milk lipids including many on fatty acid (FA) composition. The effects of maternal diets on the profiles are apparent. However, more data on the composition of milk lipids are needed. It is noteworthy that so few papers on milk FA composition have reported analyses using high-resolution gas-liquid chromatography columns. Two of these were on milk from women in North America. The diets in North America are varied and the number of analyses few. We do not have a reliable data base showing the ranges of biologically important acids. Except for the gangliosides, few new data on the other lipids appeared during this period.
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Abbreviations
- BSSL:
-
bile salt-stimulated lipase
- C:
-
cholesterol
- CE:
-
cholesteryl ester
- CLA:
-
conjugated linoleic acid
- DHA:
-
docosahexaenoic acid
- DG:
-
diglyceride, diacylglycerol
- FA:
-
fatty acid
- FAME:
-
fatt acid methyl ester
- FFA:
-
free fatty acid
- GLC:
-
gas-liquid chromatography
- HODE:
-
hydroxyoctadecadienoic
- HPLC:
-
high-performance liquid chromatography
- LBSA:
-
lipid-bound sialic acid
- LCPUF:
-
long-chain polyunsaturated fatty acids
- LDL:
-
low density lipoproteins
- MG:
-
monoglyceride, monoacylglycerol
- MLGM:
-
milk lipid globule membrane
- MP:
-
melting point
- MMP:
-
mean melting point
- MS:
-
mass spectrometry
- PL:
-
phospholipid
- PUFA:
-
polyunsaturated fatty acid
- TG:
-
triglyceride, triacylglycerol
- TLC:
-
thin-layer chromatography
References
Jensen, R.G. (1996) The Lipids in Human Milk, Prog. Lipid Res. 35, 53–92.
Keenan, T.W., and Patton, S. (1995) The Milk Lipid Globule Membrane, in The Handbook of Milk Composition (Jensen, R.G., ed.), pp. 5–50, Academic Press, San Diego.
Ferris, A.M., and Jensen, R.G. (1984) Lipids in Human Milk: A Review 1. Sampling, Determination, and Content, J. Pediatr. Gastroenterol. Nutr. 3, 100–122.
Neville, M.C. (1995) Sampling and Storage of Human Milk, in The Handbook of Milk Composition (Jensen, R.G., ed.) pp. 63–78, Academic Press, San Diego.
Jensen, R.G., Lammi-Keefe, C.J., and Koletzko, B. (1997) Representative Sampling of Human Milk and the Extraction of Fat for Analysis of Environmental Lipophilic Contaminants, Toxicol. Environ. Chem. 62, 229–247.
Quinsey, P.M., Donohue, P.C., Cumming, F.J., and Ahokas, J.T. (1996) The Importance of Measured Exposure of Breast-Fed Infants to Organochlorines, Eur. J. Clin. Nutr. 50, 438–442.
Neville, M.C. (1995) Volume and Caloric Density of Human Milk, in The Handbook of Milk Composition (Jensen, R.G., ed.) pp. 99–113, Academic Press, San Diego.
Villalpando, S., del Prado-Manriquez, M., Stafford, J., and Delgado, G. (1996) Diurnal Variations in the Fatty Acid Composition of Milk Fat from Marginally Nourished Women, Arch. Med. Res. 26, S139-S143.
Jensen, R.G., Bitman, J., Wood, D.L., Hamosh, M., Clandinin, M.T., and Clark, R.M. (1985) Methods for the Analysis of Human Milk Lipids, in Human Lactation: Milk Components and Methodologies (Jensen, R.G., and Neville, M.C., eds.), pp. 97–112, Plenum Press, New York.
Lucas, A., Gibbs, J.A.H., Lyster, R.L.J., and Baum, J.D. (1980) Simple Clinical Technique for Estimating Fat Concentration and Energy Value of Human Milk, Br. Med. J. 1, 1018–1020.
Clark, R.M., Ferris, A.M., Fey, M., Brown, R.B., Hundreiser, K.E., and Jensen, R.G. (1982) Changes in the Lipids of Human Milk from 2 to 6 Weeks Postpartum, J. Pediatr. Gastroenterol. Nutr. 1, 311–315.
Collins, S.E., Jackson, M.B., Lammi-Keefe, C.J., and Jensen, R.G. (1989) The Simultaneous Separation and Quantitation of Human Milk Lipids, Lipids 24, 746–749.
Jensen, R.G., Bitman, J., Carlson, S.E., Couch, S.C., Hamosh, M., and Newburg, D.S. (1995) Human Milk Lipids, in The Handbook of Milk Composition (Jensen, R.G., ed.), pp. 495–542, Academic Press, San Diego.
Michaelsen, K.F., Skafte, L., Badsberg, J.H., and Jorgensen, M. (1990) Variation in Micronutrients in Human Bank Milk: Influencing Factors and Implications for Human Milk Banking, J. Pediatr. Gastroenterol. Nutr. 11, 229–239.
Bitman, J., Wood, D.L., Hamosh, M., Hamosh, P., and Mehta, N.R. (1983) Comparison of the Lipid Composition of Breast Milk from Mothers of Term and Preterm Infants, Am. J. Clin. Nutr. 38, 300–312.
Bitman, J., Wood, D.L., Mehta, N.R., Hamosh, P., and Hamosh, M. (1985) Comparison of the Cholesteryl Ester Composition of Human Milk from Preterm and Term Mothers, J. Pediatr. Gastroenterol. Nutr. 5, 780–786.
Bracco, U. (1994) Effect of Triglyceride Structure on Fat Absorption, Am. J. Clin. Nutr. 60, 1002S-1009S.
Hamosh, M. (1995) Lipid Metabolism in Pediatric Nutrition, Pediatr. Clin. North Am. 42, 839–859.
Timmen, H., and Patton, S. (1988) Milk Fat Globules: Fatty Acid Composition, Size and in Vivo Regulation of Fat Liquidity, Lipids 23, 685–689.
Holman, R.T., Johnson, S.B., and Ogburn, P.L. (1991) Deficiency of Essential Fatty Acids and Membrane Fluidity During Pregnancy and Lactation, Proc. Natl. Acad. Sci. 88, 4835–4839.
Brown, J.B., and Orlans, B.M. (1946) The Fatty Acids of Human Milk Fat, Arch. Biochem. 9, 201–219.
Martin, J.-M., Bougnoux, P., Antoine, J.-M., and Lanson, M. (1993) Triacylglycerol Structure of Human Colostrum and Mature Milk, Lipids 28, 637–643.
Jensen, R.G., Ferris, A.M., Lammi-Keefe, C.J., Stewart, C.A., and DelSavio, G.C. (1990) Hypocholesterolemic Human Milk, J. Pediatr. Gastroenterol. Nutr. 10, 148–150.
Carnielli, V.P., Luijendijk, I.H.T., VanGoudoever, J.B., Sulkers, E.J., Boerlage, A.A., Degenhart, H.J., and Sauer, P.J.J.C. (1996) Structural Position and the Amount of Palmitic Acid in Infant Formulas: Effects on Fat, Fatty Acid, and Mineral Balance, J. Pediatr. Gastroenterol. Nutr. 23, 553–560.
Breckenridge, W.C., and Kuksis, A. (1967) Molecular Weight Distributions of Milk Fat Triglycerides of Seven Species, J. Lipid Res. 8, 473–478.
Breckenridge, W.C., Marai, L., and Kuksis A. (1969) Triglyceride Structure of Human Milk Fat, Can. J. Biochem. 47, 761–769.
Kuksis, A., and Breckenridge, W.C. (1968). Triglyceride Composition of Milk Fats, in Dairy Lipids and Lipid Metabolism (Brink, M.F., and Kritchevsky, D., eds.), pp. 28–98, AVI Publishing Co., Westport, CT.
Winter, C.H., Hoving, E.B., and Muskiet, A.J. (1993) Fatty Acid Composition of Human Milk Triglyceride Species, J. Chromatogr. 616, 9–24.
Currie, G.J., and Kallio, H. (1993) Triacylglycerols of Human Milk: Rapid Analysis by Ammonia Negative Ion Tandem Mass Spectrometry, Lipids 28, 217–222.
Jensen, R.G., and Hamosh, M. (1996). Selectivity of Lipases: Types and Determination, in Engineering of/with Lipases (Malcata, F.X., ed.), pp. 17–29, Kluwer Academic Publishing.
Hernell, O., and Blackberg, L. (1997). Digestion, and Absorption of Human Milk Lipids, Encycl. Hum. Biol. 3, 319–328.
Armand, M., Hamosh, M., Mehta, N.R., Angelus, P.A., Philpott, J.R., Henderson, T.R., Duyer, N.K., Lairun, D., and Hamosh, P. (1996) Effect of Human Milk or Formula on Gastric Function and Fat Digestion in the Premature Infant, Pediatr. Res. 40, 429–437.
Isaacs, C.E., Litou, R.E., and Thormar, H. (1995) Antimicrobial Activity of Lipids Added to Human Milk, Infant Formula, and Bovine Milk, Nutr. Biochem. 6, 362–366.
Innis, S.M., Dyer, R., and Nelson, C.M. (1994) Evidence That Palmitic Acid Is Absorbed as sn-2 Monoacylglycerol from Human Milk by Breast-Fed Infants, Lipids 29, 541–545.
Chen, Q., Blacksberg, L., Nilsson, A., Stornby, B., and Hernell, O. (1994) Digestion of Triacylglycerol Containing Long-Chain Polyenoic Fatty Acids in vitro by Colipase-Dependent Pancreatic Lipase and Human Milk Bile-Salt Stimulated Lipase, Biochim. Biophys. Acta 1210, 239–243.
Glew, R.H., Omene, J.A., Vignetti, S., D’Amico, M., and Evans, R.W. (1995) Fatty Acid Composition of Breast Milk Lipids of Nigerian Women, Nutr. Res. 15, 477–489.
Bitman, J., Wood, D.L., Mehta, N.S., Hamosh, P., and Hamosh, M. (1984) Comparison of the Phospholipid Composition of Breast Milk from Mothers of Term and Preterm Infants During Lactation, Am. J. Clin. Nutr. 40, 1108–1119.
Hundrieser, K.E., Clark, R.M., and Jensen, R.G. (1985) Total Phospholipid Analysis in Human Milk without Acid Digestion, Am. J. Clin. Nutr. 41, 988–993.
Harzer, G., Hang, M., Dieterich, I., and Gentner, P. (1983) Changing Patterns of Human Milk Lipids in the Course of Lactation and During the Day, Am. J. Clin. Nutr. 37, 612–621.
Hundreiser, K.M., and Clark, R.M. (1988) A Method for Separation of Phospholipid Classes in Human Milk, J. Dairy Sci. 7, 61–67.
van Beusekom, C.M., Martini, I.A., Rutgers, H.K., Boersma, E.R., and Muskiet, F.A.J. (1990) A Carbohydrate-Rich Diet Not Only Leads to Incorporation of Medium-Chain Fatty Acids (6∶0–14∶0) in Milk Triglycerides but Also in Each Milk Phospholipid Subclass, Am. J. Clin. Nutr. 52, 326–334.
Yonekubo, A., Arima, H., and Yamamoto, Y. (1987) The Composition of Japanese Human Milk(III)-Polunsaturated Fatty Acid Composition and Sterol and Phospholipid Contents, Sukusuka Press, Meiji Milk Products Formula Co., Ltd. (English version of paper published in J. Child Health 46, 349–352, 1987).
Idota, F., Sakurai, T., Sugawara, M., Matuoka, Y., Ishiyama, Y., Murakami, Y., Moriguchi, H., Takuchi, M., Shimoda, K., and Asai, Y. (1991) The Latest Survey for the Composition of Human Milk Obtained from Japanese Mothers. Part II. Changes in Fatty Acid Composition, Phospholipid and Cholesterol Contents During Lactation, Jpn. J. Pediatr. Gastroenterol. Nutr. 5, 159–173.
Holmes-McNary, M.Q., Cheng, W.-L., Mar, M.-H., Fussell, S., and Zeisel, S.H. (1996) Choline and Choline Esters in Human and Rat Milk and in Infant Formulas, Am. J. Clin. Nutr. 64, 572–576.
Hallgren, B., Niklasson, A., Stallberg, G., and Thorin, H. (1978) On the Occurrence of 1-0-Alkylglycerols and 1-0-(-2-2methoxyalkyl) Glycerols in Human Colostrum, Human Milk, Cow’s Milk, Sheep’s Milk, Human Bone Marrow, Red Cells Blood Plasma and a Uterine Carcinoma, Acta Chem. Scand. B28, 1029–1034.
Kuksis, A., Marai, L., Myher, J.J., Cerbulis, J., and Farrell, H.M., Jr. (1986) Comparative Study of the Molecular Species of Chloropropanediol Diesters and Triacylglycerols in Milk Fat, Lipids 21, 183–190.
Bouhours, J.-F., and Bouhours, D. (1981) Ceramide Structure of Sphingomyelin from Human Milk Fat Globule Membranes, Lipids, 16, 726–731.
Ziesel, S.H., Char, D., and Sheard, M.F. (1986) Choline, Phosphatidylcholine and Sphingomyelin in Human and Bovine Milk and Infant Formula, J. Nutr. 116, 50–58.
Grimmonprez, L., and Montreuil, J. (1977) Étude des Fractions Glycanniques des Glycosphingolipides Totaux de la Membrane des Globules Lipidiques de Lait de Femme, Biochimie 59, 899–908.
Bouhours, J.-F., and Bouhours, D. (1979) Galactosylceramide is the Major Cerebroside of Human Milk Fat Globule Membrane, Biochem. Biophys. Res. Commun. 88, 1217–1222.
Laegreid, A., Otnaess, A.B.B., and Fugelsang, J. (1986) Human and Bovine Milks: Comparison of Ganglioside Compositions and Enterotoxin Inhibitory Activity, Pediatr. Res. 20, 416–420.
Takamizawa, K., Iwamori, M., Mutai, M., and Nagai, Y. (1986) Selective Changes in Gangliosides of Human Milk for the Period of Lactation, Biochim. Biophys. Acta 879, 73–77.
Rueda, R., Puente, R., Hueso, P., Maldonado, J., and Gil, A. (1995) New Data on Content and Distribution of Gangliosides in Human Milk, Biol. Chem. Hoppe-Seyler 376, 723–727.
Newberg, D.S., and Chaturvedi, P. (1997) Sulfated Glycolipids in Human Milk, Am. Pediatr. Soc., Pediatr. Res. Abstr. Presented at meeting.
Newburg, D.S., and Chaturvedi (1992) Neutral Glycolipids of Human and Bovine Milk, Lipids 27, 923–927.
Newburg, D.S., Ashkenazi, S., and Cleary, T.G. (1992) Human Milk Contains the Shiga Toxin and Shiga-Like Toxin Receptor, Glycolipid Gb3, J. Infect. Dis. 166, 832–836.
Kolsto-Otnaess, A.B. (1989) Nonimmunoglobulin in Human Milk—Candidates for Prophylaxis Against Infections, in Protein and Non-Protein, in Human Milk (Atkinson, S.A., and Lonnerdal, B., eds.), pp. 211–220 CRC Press, Boca Raton.
Svennerholm, L. (1980) Ganglioside Metabolism, in Comprehensive Biochemistry (Florkin, M., and Stotz, E.H. eds.), Vol. 18, pp. 201–227, Elsevier, Amsterdam.
Keenan, T.W. and Patton, S. (1995) The Milk Lipid Globule Membrane, in The Handbook of Milk Composition (Jensen, R.G., ed), pp. 5–50, Academic Press, Inc., San Diego.
Rueda, R., Garcia-Salmeron, J.L., Maldonado, J., and Gil, A. (1996) Changes During Lactation in Ganglioside Distribution in Human Milk from Mothers Delivering Preterm and Term Infants, Biol. Chem. 377, 599–601.
Rueda, R., Maldonado, J., and Gil, A. (1996) Comparison of Content of and Distribution of Human Milk Gangliosides from Spanish and Panamanian Mothers, Ann. Nutr. Metab. 40, 194–201.
Jumpsen, J., and Clandinin, M.T. (1995) Brain Development: Relationship to Lipid and Lipid Metabolism, AOCS Press, Champaign.
Huisman, M., van Beusekom, C.M., Lantins, C.I., Nijeboor, N.J., Muskiet, F.A.J., and Boersma, E.R. (1995) Triglycerides, Fatty Acids, Sterols, Mono- and Disaccharides and Sugar Alcohols in Human Milk and Current Types of Infant Formula Milk, Eur. J. Clin. Nutr. 50, 255–260.
Bachman, K.C., and Wilcox, C.J. (1976) Factors That Influence Milk Cholesterol and Lipid Phosphorus: Content and Distribution, J. Dairy Sci. 59, 1381–1387.
Kallio, M.T.J., Siims, M.A., Perheentupa, J., Salmenpeera, L., and Miettanen, T.A. (1989) Cholesterol and Its Precursors in Human Milk During Prolonged Exclusive Breast Feeding, Am. J. Clin. Nutr. 50, 782–785.
Bracco, U., Hidalgo, J., and Bohren, H. (1973) Lipid Composition of the Fat Globule Membrane of Bovine and Human Milk, J. Dairy Sci. 55, 155–172.
Haug, M., and Harzer, G. (1984) Cholesterol and Other Sterols in Human Milk, J. Pediatr. Gastroenterol. Nutr. 3, 816–817.
Lammi-Keefe, C.J. (1995) Vitamins D and E in Human Milk, in The Handbook of Milk Composition (Jensen, R.G., ed.), pp. 706–717, Academic Press, San Diego.
Koldovsky, O., and Strbak, V. (1995) Hormones and Growth Factors in Human Milk, in The Handbook of Milk Composition (Jensen, R.G., ed.), pp. 428–435, Academic Press, San Diego.
Jensen, R.G., Lammi-Keefe, C.J., Ferris, A.M., Jackson, M.B., Couch, S.C., Capacchione, C.M., Ahn, H.S., and Murtaugh, M. (1990) Human Milk, total Lipid and Cholesterol Are Dependent on Interval of Sampling During 24 Hours, J. Pediatr. Gastroenterol. Nutr. 20, 91–94.
Wong, W.W., Hachey, D.L., Insull, W., Opekun, A.R., and Klein, P.D. (1993) Effect of Dietary Cholesterol on Cholesterol Synthesis in Breast-Fed and Formula-Fed Infants J. Lipid Res. 34, 1403–1411.
Boersma, E.R., Offringa, R.P.J., Muskiet, F.A.J., Cheere, M.W., and Simmons, I.J. (1991) Vitamin E, Lipid Fractions, and Fatty Acid Composition of Colostrum, Transitional Milk, and Mature Milk: An International Collaborative Study, Am. J. Clin. Nutr. 53, 1197–1204.
Reiser, R., O’Brien, B.C., Henderson, G.R., and Moore, G.R. (1979) Studies on a Possible Function of Cholesterol in Milk, Nutr. Rep. Int. 19, 835–849.
Mott, G.E., DeLallo, L., Driscoll, D.M., McMahan, C.A., and Lewis, D.S. (1993) Influence of Breast and Formula Feeding on Hepatic Concentrations of Apolipoprotein and Low-Density Lipoprotein Receptor in RNA, Biochim. Biophys. Acta 1169, 59–65.
Katoku, Y., Yamada, M., Yonekubo, A., Kuwata, T., Kobayoshi, A., and Sawa, A. (1996) Effect of the Cholesterol Content of a Formula on the Lipid Composition of Plasma Lipoproteins and Red Blood Cell Membranes in Early Infancy, Am. J. Clin. Nutr. 64, 871–877.
Boehm, G., Moro, G., Muller, D.M., Raffler, G., and Minoli, I. (1995) Fecal Cholesterol Excretion in Preterm Infants Fed Breast Milk or Formula with Different Cholesterol Contents, Acta Paediatr. 84, 240–244.
Routi, T., Ronnemaa, T., Lapinleimu, H., Salo, P., Vikari, J., Leino, A., Valimaki, I., Jakinen, E., Valimaki, I., Jokeni, E., and Simell, O. (1995) Effect of Weaning on Serum Lipoprotein(a) Concentration: The STRIP Baby Study, Pediatr. Res. 38, 522–527.
Cruz, M.L.A., Wong, W.W., Mimouni, F., Hachey, D.L., Setchell, K.D.R., Klein, P.D., and Tsang, R.C. (1994) Effects of Infant Nutrition on Cholesterol Synthesis Rates, Pediatr. Res. 35, 135–140.
Franke, A., and Custer, L.J. (1996) Daidzein and Genistein Concentrations in Human Milk After Soy Consumption, Clin. Chem. 42, 955–964.
Jensen, R.G. (1989) The Lipids of Human Milk, CRC Press, Boca Raton.
Clark, R.M., and Roche, M.E. (1990) Gas Chromatographic Procedure for Measuring Total Lipids in Breast Milk, J. Pediatr. Gastroenterol. Nutr. 10, 271–272.
Kohn, G., Ploeg, P., van der, Mobius, M., and Sawatzki, G. (1996) Influence of the Derivatization Procedure on the Results of the Gas Chromatographic Fatty Acid Analysis of Human Milk and Infant Formula, Z. Ehrnahrwissensch 35, 226–234.
Christie, W.W. (1989) Gas Chromatography and Lipids, pp. 64–71, The Oily Press, Ayr.
Lepage, G., and Roy, C.C. (1984) Improved Recovery of Fatty Acids Through Direct Transesterification Without Prior Extraction or Purification, J. Lipid Res. 25, 1391–1396.
Morrison, W.R., and Smith, L.M. (1964) Preparation of Fatty Acid Methyl Esters and Dimethyacetals from Lipids with Boron Fluoride-Methanol, J. Lipid Res. 5, 600–608.
Stoffel, W., Chu, F., and Ahrens, E.H. (1959) Analysis of Long-Chain Fatty Acids by Gas-Liquid Chromatography. Micromethod for Preparation of methyl Esters, Anal. Chem. 31, 307–308.
Kramer, J.K.G., Fellner, V., Dugon, M.E.R., Sauer, F.D., Mossoba, M.M., and Yurawecz, M.P. (1997) Evaluating Acid and Base Catalysts in the Methylation of Milk and Rumen Fatty Acids with Special Emphasis on Conjugated Dienes and Total trans Fatty Acids, Lipids 32, 1219–1228.
Takayama, M. (1994) Simple Analysis of Fatty Acids of Human Milk by HPLC, Jpn. J. Clin. Pathol. 42, 873–877.
Carpenter, D.E., Ngeh-Ngwainbi, I., and Lee, S. (1993) Lipid Analysis, in Methods of Analysis for Nutrition Analysis (Sullivan, D.M., and Carpenter, D.E., eds.), pp. 85–104, AOAC International, Arlington.
Glass, R.L., and Christopherson, S.W. (1969) A Method for the Differential Analysis of Mixtures of Esterified and Free Fatty Acids, Chem. Phys. Lipids 3, 405–408.
Neville, M.C., and Picciano, M.D. (1997) Regulation of Milk Lipid Secretion and Composition, Annu. Rev. Nutr. 17, 159–184.
Idota, T., Sakurai, M., Sugawara, Y., Ishiyama, Y., Murakami, Y., Moriguchi, H., Takeuchi, M., Shimoda, K., and Asai, Y. (1991) The Latest Survey for the Composition of Milk Obtained from Japanese Mothers. Part II. Changes of Fatty Acid Composition, Phospholipid and Cholesterol Contents During Lactation, Jpn. J. Pediatr. Gastroenterol. Nutr. 5, 159–173.
Gere, A., Bernolak, E.A., Gaal, O., Cholnoky, P., and Ory, I. (1983) Fatty Acid Composition of Human Milk and Milk-Based Formulas in Hungary, Acta Paediatr. Hungar. 24, 53–61.
Dagnelie, P.C., van Staversen, W.A., Roose, A.H., Tuinstra, L.G.M.T., and Burema, Jr. (1992) Nutrients and Contaminants in Human Milk from Mothers on Macrobiotic and Omnivorous Diets, Eur. J. Clin. Nutr. 46, 355–366.
Ogunleye, A., Fakoya, A.T., Miizeki, S., Tojo, H., Sasajima, I., Kobayashi, M., Tateishi, S., and Yamaguchi, K. (1991) Fatty Acid Composition of Breast Milk from Nigerian and Japanese Women, J. Nutr. Sci. Vitaminol. 37, 435–442.
Budowski, P., Druckman, H., and Kaplan, P. (1994) Mature Milk from Israeli Mothers is Rich in Polyunsaturated Fatty Acids; Fatty Acids and Lipids: Biological Aspects, World Rev. Nutr. Diet. 75, 105–108.
Chen, Z.-Y., Pelletier, G., Hollywood, R., and Ratnayake, W.M.N. (1995) Trans Fatty Acid Isomers in Canadian Human Milk, Lipids 30, 15–21.
Chardigny, J.-M., Wolff, R.L., Sébédio, J.-L., Martine, L., and Juaneda, P. (1995) Trans Mono- and Polyunsaturated Fatty Acids in Human Milk, Eur. J. Clin. Nutr. 49, 523–531.
Hands, E.S. (1996) Lipid Composition of Selected Foods, in Bailey’s Industrial Oil and Fat Products, Vol. I, 5th edn. (Hui, Y.S., ed.), pp. 444–445, Wiley-Interscience, New York.
Koletzko, B., Mrotzek, M., and Bremer, H.J. (1991) Fatty Acid Composition of Mature Human Milk in Nigeria, Z. Ernahrungswiss.-Eur. J. Nutr. 30, 289–297.
Laryea, M.D., Leichsenring M., Mrotzek, M., El-Amin, E.O., El-Kharib, A.O., Ahmed, H.M., and Bremer, H.J. (1995). Fatty Acid Composition of the Milk of Well-Nourished Sudanese Women, Int. J. Food Sci. Nutr. 46, 205–214.
Chulei, R., Xiaofang, L., Hongsheng, M., Yiulan, M., Guizheng, L., Gianhoug, D., DeFrancesco, C.A., and Connor, W.E. (1995) Milk Composition in Women from Five Different Regions of China: The Great Diversity of Milk Fatty Acids, J. Nutr. 125, 2993–2998.
De la Presa-Owens, S., Lopez-Sabater, M.D., and Rivero-Urgell, M. (1996) Fatty Acid Composition of Human Milk in Spain, J. Pediatr. Gastroenterol. Nutr. 22, 180–185.
Beijers, R.J.W., and Schaafsma, A. (1996) Long-Chain Polyunsaturated Fatty Acid Content in Dutch Preterm Breast Milk; Differences in the Concentrations of Docosahexaenoic Acid and Arachidonic Acid Due to Length of Gestation, Early Hum. Dev. 44, 215–223.
Genzel-Boroviczeny, O., Wabel, J., and Koletzko, B. (1997) Fatty Acid Composition of Human Milk During the First Month After Term and Preterm Delivery, Eur. J. Pediatr 156, 142–147.
Desci, T., Tibor, E., and Koletzko, B. (1997) Fatty Acid Composition of Colostrum, Mature Human Milk and Infant Formula, Gyemekgy 48, 18–26.
Guesnet, P., Couet, C., Alessandri, J.M., Antoine, J.M. and Durand, G. (1995) Variability in Linoleic Acid (18∶2n−6) Content and 18∶2n−6/18∶3n−3 Ratio in Human Breast Milk in France, Ann. Pediatr. (Paris) 42, 282–286.
Makrides, M., Simmer, K., Neumann, M., and Gibson, R. (1995) Changes in the Polyunsaturated Fatty Acids of Breast Milk from Mothers of Full Term Infants Over 30 Weeks of Lactation, Am. J. Clin. Nutr. 61, 1231–1233.
Gibson, R.K., and Kneebone, G.M. (1981) Fatty Acid Composition of Human Colostrum and Mature Breast Milk, Am. J. Clin. Nutr. 34, 252–257.
Cherian, G., and Sim, J.S. (1996) Changes in the Breast Milk Fatty Acids and Plasma Lipids of Nursing Mothers Following Consumption of n−3 Polyunsaturated Fatty Acid Enriched Eggs, Nutrition 12, 8–12.
Makrides, M., Neumann, M.A., and Gibson, R.A. (1996) Effect of Maternal Docosahexaenoic Acid (DHA) Supplementation on Breast Milk Composition, Eur. J. Clin. Nutr. 50, 352–357.
Al-Othman, A.A., El-Fawaz, J.A., Hewdy, F.M., and Abdullah, N.M. (1996) Fatty Acid Composition of Mature Breast Milk of Saudi Lactating Mothers, Food Chem. 57, 211–215.
Luukkainen, P., Salo, M.K., and Nikkari, T. (1995) The Fatty Acid Composition of Banked Human Milk and Infant Formulas: The Choices of Milk for Feeding Preterm Infants, Eur. J. Pediatrics, 154, 316–319.
Jorgensen, M.H., Lassen, A., and Michaelsen, K.F. (1995) Fatty Acid Composition in Danish Infant Formula Compared to Human Milk, Scand. J. Nutr. 39, 50–54.
Sera, G., Marletta, A., Bonacci, W., Campone, F., Bertini, I., Lantieri, P.B., Risso, D., and Ciangherotti, S. (1997) Fatty Acid Composition of Human Milk in Italy, Biol. Neonate 72, 1–8.
Villalpando, S., Del Prado-Manriquez, M., Stafford, J., and Delgado, G. (1995) Diurnal Variations in the Fatty acid Composition of Milk Fat from Marginally Nourished Women, Arch. Med. Res. 25, S139-S143.
Kinsella, J.E. (1979) Stearic Acid Metabolism by Mammary Cells, J. Dairy Sci. 53, 1757–1765.
Carlson, S.E., Clandinin, M.T., Cook, H.W., Emken, E.A., and Filer, L.J., Jr. (1997) Trans Fatty Acids: Infant and Fetal Development, Am. J. Clin. Nutr. 66, 717S-736S.
Precht, D., and Molkentin, J. (1996) Rapid Analysis of the Isomers of trans-Octadecenoic Acid in Milk Fat, Int. Dairy J. 6, 791–809.
Craig-Schmidt, M.C., Weete, M.C., Faircloth, J.D., Wickwire, M.A., and Livant, E.J. (1984) The Effect of Dietary Fat in the Diet of Nursing Mothers on Lipid Composition and Prostaglandin Content of Human Milk, Am. J. Clin. Nutr. 39, 778–786.
Jensen, R.G., and Lammi-Keefe, C.J. (1998) Cutrent Status of Research on Bovine and Human Milk Lipids, in Lipids in Infant Nutrition (Huang, Y-S., and Sinclair, A.J., eds.), pp. 168–191, AOCS Press, Champaign. Ch. 13.
Aitchison, J.M., Dunkley, W.L., Canolty, N.L., and Smith, L.M. (1977) Influence of Diet on trans Fatty Acids in Human Milk, Am. J. Clin. Nutr. 30, 2006–2015.
Picciano, M.F., and Perkins, E.G. (1977) Identification of trans Isomers of Octadecenoic Acid in Human Milk, Lipids 12, 407–408.
Clark, R.M., Ferris, A.M., Hundreiser, K.E., and Jensen, R.G. (1980) The Identity of the Cholesteryl Esters in Human Milk, Lipids 15, 972–974.
Hundreiser, K.E., Clark, R.M., and Brown, P.B. (1983) Distribution of trans-Octadecenoic Acid in the Major Glycerolipids of Human Milk, Lipids 18, 635–639.
Finley, D.A., Lonnerdal, B., Dewey, K.G., and Grivetti, L.E. (1985) Breast Milk Composition: Fat Content and Fatty Acid Composition in Vegetarians and Non-Vegetarians, Am. J. Clin. Nutr. 41, 787–800.
Homer, D. (1985), Analysis of Milkfat and Modified Milkrat by Gas Chromatography, in Proc. 13th Scandinavian Sumposium on Lipids (Marcuse, R., ed.), pp. 159–165, LipidForum, Göteborg, Sweden.
Chappell, J.E., Clandinin, M.T., and Kearey-Volpe, C. (1985) Trans Fatty Acids in Human Milk Lipids: Influence of Maternal Diet and Weight Loss, Am. J. Clin. Nutr. 42, 49–56.
Koletzko, B., Mrotzek, M., Eng, B., and Brenner, H.J. (1988) Fatty Acid Composition of Mature Human Milk in Germany, Am. J. Clin. Nutr. 47, 954–959.
Dotson, K.D., Jerrel, J.P., Picciano, M.F., and Perkins, E.G. (1992) High-Performance Liquid Chromatography of Human Milk Triacylglycerols and Gas Chromatography of Component Fatty Acids, Lipids 27, 933–939.
Boatella, J., Rafecas, M., Codony, M., Gibert, A., Rivero, M., Tormo, R., Infante, D., and Sanchez-Valverde, F. (1993) Trans Fatty Acid Content of Human Milk in Spain, J. Pediatr. Gastroenterol. Nutr. 16, 432–434.
Wolff, R. (1995) Content and Distribution of trans-18∶1 Acids in Ruminant Milk and Meat Fats. Their Importance in European Diets and Their Effect on Human Milk, J. Am. Oil. Chem. Soc. 72, 259–272.
Jorgensen, M.H., Lessen, A., and Michaelsen K.F. (1995) Fatty Acid Composition in Danish Infant Formula Compared to Human Milk, Scan. J. Nutr. 39, 50–54.
Teter, B.B., Sampugna, J., and Keeney, M. (1990) Milk Fat Depression in C57BJ/6J Mice Consuming Partially Hydrogenated Fat, J. Nutr. 120, 818–824.
Wonsil, B.J., Herbein, H., and Watkins, B.J. (1994) Dietary and Ruminally Derived trans-18∶1 Fatty Acids Alter Bovine Milk Lipids, J. Nutr. 124, 556–565.
Gaynor, P.J., Erdman, R.A., Teter, B.B., Sampugna, J., Capuco, A.V., Waldo, D.R., and Hamosh, M. (1994) Milk Fat Yield and Composition During Abomasal Infusion of Cis or Trans Octadecenoates in Holstein Cows, J. Dairy Sci. 77, 157–165.
Khosla, P., and Hayes, K.C. (1996) Dietary Trans-Monounsaturated Fatty Acids Negatively Impact Plasma Lipids in Humans: Critical Review of the Evidence, J. Am. Coll. Nutr. 15, 325–339.
AIN/ASCN Task Force on Trans Fatty Acids (1996) Position Paper on Trans Fatty Acids, Am. J. Clin. Nutr. 63, 663–670.
Ascherio, A., and Willett, W.C. (1997) Health Effects of trans Fatty Acids, Am. J. Clin. Nutr. 66, 1006S-1010S.
Shapiro, S. (1997) Do trans Fatty Acids Increase the Risk of Coronary Artery Disease? A Critique of the Epidemiologic Evidence, Am. J. Clin. Nutr. 66, 1011S-1017S.
Koletzko, B. (1995) Trans Fatty Acids of Long-Chain Polyunsaturates and Growth in Man, Acta Paediatr. 81, 302–306.
Decsi, T., and Koletzko, B. (1995) Do trans Fatty Acids Impair Linoleic Acid Metabolism in Children? Ann. Nutr. Metab. 39, 36–41.
Koletzko, B. (1995) Potential Adverse Effects of Trans Fatty Acids in Infants and Children, Eur. J. Med. Res. 1, 123–125.
Holman, R.T., Caster, W.O., and Wiese, H.G. (1964) The Essential Fatty Acid Requirement of Infants and Assessment of Their Dietary Intake of Linoleate by Serum Fatty Acids Analysis, Am. J. Clin. Nutr. 14, 70–75.
Holman, R.T., Johnson, S.B., and Hatch, T.F. (1982) A Case of Human Linocenic Acid Deficiency Involving Neurological Abnormalities, Am. J. Clin. Nutr. 35, 617–623.
Innis, S.M. (1991) Essential Fatty Acids in Growth and Development, Prog. Lipid Res. 30, 39–103.
Sprecher, H., Luthria, D.L., Mohammed, B.S., and Baykouskera, S.P. (1995) Re-evaluation of the Rathways for the Biosynthesis of Polyunsaturated Fatty Acids, J. Lipid Res. 36, 2471–2477.
Greiner, R.C.S., Zhang, Q., Goodman, K.I., Giusanni D.A., Nathanielsz, P.M., and Brenna, T.W. (1996) Linoleate, Linolenate, and Docosahexaenoate Recycling into Saturated and Monounsaturated Acids Is a Major Pathway in Pregnant or Lactating Adults and Fetal or Infant Rhesus Monkeys, J. Lipid Res. 37, 2675–2686.
Inaull, W., Hirsch, J., James, T., and Ahren, E.H., Jr. (1959) The Fatty Acids of Human Milk. I. Alterations Produced by Manipulation of Caloric Balance and Exchange of Dietary Fats, J. Clin. Invest. 38, 443–450.
Jensen, R.G., Hagerty, M.M., and McMahon, K.E. (1978) Lipids of Human Milk and Infant Formulas: A Review, Am. J. Clin. Nutr. 31, 990–1016.
Sheaff, R.C., Su, H.-M., Keswick, L.A., and Brenna, J.T. (1995) Conversion of Linolenate to Docosahexaenoate Is Not Depressed by High Dietary Levels of Linoleate in Young Rats: Tracer Evidence Using High Precision Mass Spectrometry, J. Lipid Res. 36, 998–1008.
Lands, W.E.M. (1997) The Two Faces of Essential Fatty Acids, INFORM 8, 1141–1147.
European Society of Paediatric Gastroenterology and Nutrition (ESPGAN) (1991) Committee on Nutrition: Comment on the Content and Composition of Lipids in Infant Formulas, Acta Paediatr. Scand, 80, 887–896.
Sauerwald, T.U., Hachey, D.L., Jensen, C.L., Chen, H., Anderson, R.E., and Heird, W.C. (1996) Effect of Dietary Linolenic Acid Intake on Incorporation of Docosahexaenoic and Arachidonic Acids into Plasma Phospholipids of Term Infants, Lipids 31, S-131–S-135.
Carnielli, V.P., Wattimena, J.J., Luijendijk, I.H.T., Boerlage, A., Desenhart, H.J., and Sauer, P.J.J. (1996) The Very Low Birth Weight Premature Infant Is Capable of Synthesizing Arachidonic and Docosahexaenoic Acids from Linoleic and Linolenic Acids, Pediatr. Res. 10, 169–174.
Demmelmair, H., van Schenek, U., Sauerwald, T., and Koletzko, B. (1995) Estimation of Arachidonic Acid Synthesis in Full Term Neonates Using Natural Variation of 13C Content, J. Pediatr. Gastroenterol. Nutr. 21, 31–36.
Poisson, J.-P., Dupuy, R.-P., Sarda, P., Descomps, B., Rieu, D., Varce, M., and Crastos de Paulet, A. (1993) Evidence That Liver Microsomes of Human Neonates Desaturate Essential Fatty Acids, Biochim. Biophys. Acta 1167, 109–113.
Gibson, R.A., and Makrides, M., Long Chain Polyunsaturated Fatty Acids in Breastmilk: Are They Essential? in Bioactive Substances in Human Milk (Newburg, D., ed.), Plenum, New York, in press.
Nottleton, J.A. (1995). Omega-3 Fatty Acids and Health, Chapman & Hall, New York.
Carlson, S.E., and Werkman, S.H. (1996) A Randomized Trial of Visual Attention of Preterm Infants Fed Docosahexaenoic Acid Until Two Months, Lipids 31, 85–90.
Uauy, R., and de Andraca, I. (1995) Human Milk and Breast Feeding for Optimal Mental Development, J. Nutr. 125, 2278S-2280S.
Crawford, M.A., Sinclair, A.J., Msuya, P.M., and Munhambo, A. (1973), Structural Lipids and Their Polyenoic Constituents in Human Milk, in Dietary Lipids and Postnatal Development, (Galli, C., Jacini, G., and Pecile, A., eds.) Raven Press, New York, pp. 41–56.
Crawford, M.A., Doyle, W., Dsury, P., Lennon, A., Costeloe, K., and Leighfield, M. (1989) n-6 and n-3 Fatty Acids During Early Human Development, J. Intern. Med. 225 (suppl.), 159–169.
Crawford, M. (1993) The Role of Essential Fatty Acids in Neural Development Implications for Perinatal Development, Am. J. Clin. Nutr. 57, 703S-710S.
Crawford, M.A., Costeloe, A., Ghebremeskel, K., Phylactos, A., and Stacey, F. (1997) Are Deficits of Arachidonic and Docosahexaenoic Acids Responsible for the Neutral and Vascular Complications of Preterm Babies? Am. J. Clin. Nutr. 66, 1032S-1041S.
Neuringer, M., Connor, W.E., VanPetten, C., and Barstad, C. (1984) Dietary Omega-3 Fatty Acid Deficiency and Visual Loss in Infant Rhesus Monkeys, J. Clin. Invest 73, 272–276.
Neuringer, M., Connor, W.E., Lin, D.S., Barstad, L., and Luck, S. (1986) Biochemical and Functional Effects of Prenatal and Postuatal Omega-3 Fatty Acid Deficiency on Retina and Brain in Rhesus Monkeys, Proc. Natl. Acad. Sci. USA 83 4021–4025.
Innis, S.M., Akrabawi, S.S., Diersen-Schade, D.A., Dobson, M.V., and Guy, D.G. (1997) Visual Acuity and Blood Lipids in Term Infants Fed Human Milk or Formulae, Lipids 32, 63–72.
Carlson, S.E., Werkman, S.H., Peeples, J.M., Cook, R.J., and Tolley, E.A. (1993) Arachidonic Acid Status Correlates with First Year Growth in Pretern Infants, Proc. Natl. Acad. sci. USA 90, 1073–1077.
Uatty, R., Hoffman, D.R., Birch, E.E., Birch, G.D., Jameson, D.M., and Tyson, J. (1994) Safety and Efficacy of Omega-3 Fatty Acids in the Nutrition of Very Low Birth Weight Infants: Soy Oil and Marine Oil Supplementation of Formula, J. Pediatr. 124, 612–620.
Johnson, J.A., Blackburn, M.L., Bull, A.W., Welsch, C.W., and Watson, J.T. (1997) Separation and Quantition of Linoleic Acid Oxidation Products in Mammary Gland Tissue from Mice Fed Low- and High-Fat Diets, Lipids 32, 369–375.
Hamosh, M., and Salem, N., Jr. (1998) Long-chain Polyunsaturated Fatty Acids, Biol. Neonate 74, 106–120.
Bendich, A., and Brock, P.E. (1997) Rationale for the Introduction of Long Chain Polyunsaturated Fatty Acid and for Concomitant Increase in the Level of Vitamin E in Infant Formulas, Int. J. Vit. Nutr. Res. 67, 213–231.
Parodi, D.W. (1994) Conjugated Linoleic Acid: An Anticarcinogenic Fatty Acid Present in Milk Fat, Aust. J. Dairy Technol. 49, 93–97.
Parodi, P.W. (1997) Cows’ Milk Fat Components as Potential Anticarcinogenic Agents, J. Nutr 127, 1055–1060.
Belury, M.A. (1995) Conjugated Dienoic Linoleate: A Polyunsaturated Fatty Acid with Unique Chemoprotective Properties, Nutr. Rev. 53, 83–89.
Chardigny, J.-M., Sebedio, J.-L., and Berdeaux, O. (1996) Trans Polyunsaturated Fatty Acids: Occurrence and Nutritional Implications, Adv. Appl. Lipid Res. 2, 1–33.
McGuire, M.A., McGuire, M.K., McGuire, M.S., and Grinnari, J.M. (1997), Bovinic Acid: The Natural CLA, Proc. Cornell Nutr. Conf., pp. 216–226.
Parodi, P.W. (1997) Milk Fat Conjugated Linoleic Acid: Can It Help Prevent Breast Cancer? Proc. Nutr. Soc. New Zealand 21, 137–149.
Pariza, P.W. (1997) Conjugated Linoleic Acid, A Newly Recognized Nutrient, Chem. Ind. (London. 12), 464–466.
Chin, S.F., Liu, W., Storkson, J.M., Ha, Y.L., and Pariza, M.W. (1992) Dietary Sources of Conjugated Dienoic Isomers of Linoleic Acid, a Newly Recognized Class of Anticarcinogens, J. Food Comp. Anal. 5, 185–197.
Kramer, J.K.G., Parodi, P.W., Mossoba, M.M., Yurawecz, M.P., and Adlof, R.A. (1998) Rumenic Acid. A Proposed Common Name for the Major Conjugated Linoleic Acid (CLA) Isomer Found in Natural Products, Lipids 33, 185.
Riel, R.R. (1963) Physico-Chemical Characteristics of Canadian Milk Fat. Unsaturated Fatty Acids, J. Dairy Sci. 616, 102–106.
Parodi, P.W. (1977) Gonjugated Octadecadienoic Acids in Milk Fat, J. Dairy Sci. 60, 1550–1553.
Kepler, C.R., Hirons, H.P., McNeil, J.J., and Tove, S.B. (1966) Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens J. Biol. Chem. 241, 1350–1354.
Ha, Y.L., Grimm, N.K., and Pariza, M.W. (1987) Anticarcinogens from Fried Ground Beef: Heat-Altered Derivatives of Linoleic Acid, Carcinogenesis 8, 1881–1887.
Liew, C., Schuut, H.A.J., and Dashwood, R.H. (1995) Protection of Conjugated Linoleic Acids Against 2-Amino-3-methylimidazo [4,5f] Quinoline-Induced Colon Carcinogenesis in the F344 Rat: A Study of Inhibitory Mechanisms, Carcinogenesis 16, 3037–3043.
Ip, C., Singh, M., Thompson, H.J., and Scimeca, J.A. (1994) Conjugated Linoleic Acid Suppresses Mammary Carcinogenesis and Proliferative Activity of the Mammary Gland in the Rat, Cancer Res. 54, 1212–1215.
Schultz, T.D., Chow, B.P., and Seaman, W.R. (1992) Differential Stimulating and Inhibitory Responses of Human MLF-7 Breast Cancer Cells to Linoleic Acid and Conjugated Linoleic Acid in Culture, Anticancer Res. 12, 2143–2146.
Miller, C.C., Park, Y.L., Pariza, M.W., and Cook, M.E. (1994) Feeding Conjugated Linoleic Acid to Animals Partially Overcomes Catabolic Responses Due to Endotoxin Injection, Biochem. Biophys Res. Comm. 198, 1107–1112.
Chin S.F., Storkson, J.M., Albright, K.J., Cook, M.E., and Pariza, M.W. (1994) Conjugated Linoleic Acid is a Growth Factor for Rats as Shown by Enhanced Weight Gain and Improved Food Efficiency, J. Nutr. 124, 2344–2349.
Cook, M.E., Miller, C.C., Park, Y., and Pariza, M.W. (1993) Immune Modulation by Altered Nutrient Metabolism: Nutritional Control of Immune-Induced Growth Depression, Poultry. Sci. 72, 1301–1305.
Lee, K.S.Z., Kritchevsky, D., and Pariza, M.W. (1994) Conjugated Linoleic Acid and Atherosclerosis in Rabbits Atherosclerosis 108, 19–25.
Nicolosi, R.J., Rogers, E.J., Kritchevsky, D., Scimeca, J.A., and Huth, A.J. (1997) Dietary Conjugated Linoleic Acid Reduces Plasma Lipoproteins and Early Atherosclerosis in Hypercholesterolemic Hamsters, Artery 22, 266–277.
Ha, Y.L., Storkson, J., and Pariza, M.W. (1990) Inhibition of Benzo (α) Pyrene-Induced Mouse Forestomach Neoplasia by Conjugated Dienoic Derivatives of Linoleic Acid, Cancer Res. 50, 1097–2011.
Van der Bers, J.J.M., Cook, N.L.E., and Tribble, D.L. (1995) Reinvestigation of the Antioxidant Properties of Conjugated Linoleic Acid, Lipids 30, 599–605.
Li, Y., Allen, K.D.G., and Watkins, B.A. (1997) Dietary Conjugated Linoleic Acid Reduced ex Vivo Bone PGE2 Production in Rats, Proc. Expt. Biol. 97, A165, 962.
Belury, M.A., and Kempa-Steczko, A. (1997) Conjugated Linoleic Acid Modulates Hepatic Lipid Composition in Mice, Lipids 32, 199–204.
Park, Y., Albright, K.D., Liu, Z.W., Storkson, J.M., Cook, M.E., and Pariza, P.W. (1997) Effect of Conjugated Linoleic Acid on Body Composition in Mice, Lipids 32, 853–858.
Lin, H., Boylston, T.D., Chang, M.J., Luedecke, L.O., and Shultz, T.D. (1995) Surveys of the Conjugated Linoleic Acid Contents of Dairy Products, J. Dairy Sci. 78, 2358–2365.
Precht, D., and Molkentin, J. (1997) Trans-Geometrical and Positional Isomers of Linoleic Acid Including Conjugated Linoleic Acid (CLA) in German Milk and Vegetable Fats, Fett/Lipid 99, 319–326.
Fogerty, A.C., Ford, G.L., and Svoronos, D. (1988) Octadeca-9,11-dienoic Acid in Foodstuffs and in the Lipids of Human Blood and Breast Milk, Nutr. Rep. Int. 38, 937–944.
McGuire, M.K., Park, Y., Behre, R.S., Harrison, L.Y., Shultz, T.D., and McGuire, M.A. (1997) Conjugated Linoleic Acid Concentrations of Human Milk and Formulas, Nutr. Res. 17, 1277–1283.
Jensen, R.G., Lammi-Keefe, C.J., Hill, D.W., Kind, A.J., and Henderson, R.A. (1998) The Anticarcinogenic Conjugated Fatty Acid-9c, 11t-18∶2 in Human Milk; Confirmation of Its Presence, J. Hum. Lact. 14, 23–27.
Huang, Y.-C., Luedecke, L.O., and Shultz, T.D. (1994) Effect of Cheddar Cheese Consumption on Plasma Conjugated Linoleic Acid Concentrations in Men, Nutr. Res. 3, 373–386.
Park, Y.S., Behne, R.A., McGuire, M.A., Shultz, T.D., and McGuire, M.K. (1997) Dietary Conjugated Linoleic Acid (CLA) and CLA in Human Milk, FASEB J. 11, A239.
Ip, C. (1997) Review of the Effects of trans Fatty Acids, Oleic Acid, n-3 Polyunsaturated Fatty Acids, and Conjugated Linoleic Acid on Mammary Carcinogenesis in Animals, Am. J. Clin. Nutr. 66, 1513s-1522s.
Christie, W.W., Dobson, G., and Gunstone, F.D. (1997) Isomers in Commerical Samples of Conjugated Linoleic Acid, Lipids 32, 1231.
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Jensen, R.G. Lipids in human milk. Lipids 34, 1243–1271 (1999). https://doi.org/10.1007/s11745-999-0477-2
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DOI: https://doi.org/10.1007/s11745-999-0477-2