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Hepatic Lipase Gene −514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations

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Lipids

Abstract

Hei Yi Zhuang is an isolated subgroup of the Zhuang minority in China. This study was designed to compare the difference in the hepatic lipase gene (LIPC) −514C/T polymorphism and its association with lipid profiles between the Guangxi Hei Yi Zhuang and Han populations. Genotyping of the LIPC −514C/T was performed in 873 subjects of Hei Yi Zhuang and 867 participants of Han Chinese. The frequency of −514T allele was 43.47% in Hei Yi Zhuang, and 36.10% in Han (P < 0.001). The frequencies of CC, CT and TT genotypes were 30.01, 53.04 and 16.95% in Hei Yi Zhuang, and 40.95, 45.91 and 13.14% in Han (P < 0.001); respectively. Serum high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B levels in both ethnic groups were higher in LIPC −514T carriers than in C carriers. In addition, serum triglyceride levels in Han were higher in TT genotype individuals than in CC genotype subjects (P < 0.05). Serum HDL-C levels were positively correlated with age, alcohol consumption and LIPC −514C/T genotypes, and negatively associated with hypertension and cigarette smoking in Hei Yi Zhuang (P < 0.05–0.01), whereas HDL-C levels were positively correlated with age, alcohol consumption and LIPC −514C/T genotypes, and negatively associated with body mass index and cigarette smoking in Han (P < 0.05–0.001). The differences in serum HDL-C levels between the two ethnic groups might partially attribute to the differences in the LIPC −514C/T polymorphism.

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Abbreviations

ANCOVA:

Analysis of covariance

Apo:

Apolipoprotein

BMI:

Body mass index

CHD:

Coronary heart disease

DNA:

Deoxyribonucleic acid

HDL-C:

High-density lipoprotein cholesterol

HL:

Hepatic lipase

LDL-C:

Low-density lipoprotein cholesterol

LIPC :

Hepatic lipase gene

PCR:

Polymerase chain reaction

SNP:

Single nucleotide polymorphisms

TC:

Total cholesterol

TG:

Triglyceride

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (No: 30360038).

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Authors and Affiliations

  1. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, 530021, Nanning, Guangxi, People’s Republic of China

    Jinzhen Wu & Ruixing Yin

  2. Department of Molecular Biology, Medical Scientific Research Center, Guangxi Medical University, Nanning, People’s Republic of China

    Weixiong Lin & Dezhai Yang

  3. Department of Pathophysiology, School of Premedical Sciences, Guangxi Medical University, Nanning, People’s Republic of China

    Shangling Pan

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  1. Jinzhen Wu
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  2. Ruixing Yin
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  4. Shangling Pan
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Correspondence to Ruixing Yin.

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Wu, J., Yin, R., Lin, W. et al. Hepatic Lipase Gene −514C/T Polymorphism in the Guangxi Hei Yi Zhuang and Han Populations. Lipids 43, 733–740 (2008). https://doi.org/10.1007/s11745-008-3204-3

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