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Association of L-FABP T94A and MTP I128T Polymorphisms with Hyperlipidemia in Chinese Subjects

  • Original Article
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Lipids

Abstract

The purpose of this study was to evaluate the relation between the L-FABP T94A and MTP I128T polymorphisms and hyperlipidemia in Chinese subjects. We recruited 390 volunteers: 201 hyperlipidemic and 189 healthy volunteers. The L-FABP T94A and MTP I128T polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Anthropometry, lipid profile, and liver function of the subjects were determined. We observed that male carriers of the L-FABP A94 allele had significantly higher body weight (P = 0.012), higher body mass index (BMI) (P = 0.014), and higher plasma triacylglycerol levels (TAG) (P = 0.033) and lower ratios of high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) (P = 0.008) than T94 homozygotes. The MTP T128 allele was associated with significantly lower serum TC (P < 0.001) and low-density lipoprotein cholesterol (LDL-C) (P < 0.001) levels in males. There was a direct correlation between the MTP T128 allele and a decreased risk of hyperlipidemia after adjusting for body mass index (OR = 0.327, 95 % CI: 0.178–0.600, P < 0.001). In conclusion, both the MTP I128T and the L-FABP T94A polymorphisms can affect serum lipid levels in the Chinese population. The MTP T128 allele offers protection against hyperlipidemia in the Chinese population.

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Abbreviations

apoB:

Apolipoprotein B

ALB:

Serum albumin

BMI:

Body mass index

FBG:

Fasting blood glucose

FFA:

Free fatty acid(s)

GLB:

Serum globulin

GPT:

Alanine aminotransferase

LCFA:

Long-chain fatty acids

LDL-C:

Low-density lipoprotein cholesterol

L-FABP:

Liver fatty acid binding protein

HDL-C:

High-density lipoprotein cholesterol

MTP:

Microsomal triglyceride transfer protein

PPARα:

Peroxisome proliferator-activated receptor α

STP:

Serum total protein

TC:

Total cholesterol

TAG:

Triacylglycerol

T-Bili:

Total bilirubin

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Acknowledgments

This study was supported by the National Sci-Tech Support Plan of China (SQ2010BAJY1411-08 to Dongsheng Ouyang); the National Development of Key Novel Drugs for Special Projects of China (2012ZX09303014001 to Dongsheng Ouyang); and the Hunan Scientific Plan (14JJ4006 to Dongsheng Ouyang). We thank all of the participants for their contributions to this study.

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology of Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, Changsha, 410078, China

    Yingying Tian, Hui Li, Shanbo Wang, Han Feng, Honghao Zhou & Dongsheng Ouyang

  2. The Third Xiangya Hospital, Central South University, Changsha, 410013, China

    Jin Yan & Zhiheng Chen

  3. Department of Cardiology, Xiangya Hospital, Central South University, Changsha, 410078, China

    Zhenyu Li

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  1. Yingying Tian
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  2. Hui Li
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  3. Shanbo Wang
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  4. Jin Yan
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  6. Zhenyu Li
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  7. Han Feng
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  8. Honghao Zhou
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  9. Dongsheng Ouyang
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Correspondence to Dongsheng Ouyang.

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Tian, Y., Li, H., Wang, S. et al. Association of L-FABP T94A and MTP I128T Polymorphisms with Hyperlipidemia in Chinese Subjects. Lipids 50, 275–282 (2015). https://doi.org/10.1007/s11745-015-3990-3

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  • DOI: https://doi.org/10.1007/s11745-015-3990-3

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