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Dietary Counseling and Probiotic Supplementation During Pregnancy Modify Placental Phospholipid Fatty Acids

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  • Published:
Lipids

Abstract

It has previously been shown that maternal nutrition affects the fetal environment, with consequences for the infant’s health. From early pregnancy onwards participants here received a combination of dietary counseling and probiotics (Lactobacillus GG and Bifidobacterium lactis Bb12; n = 10), dietary counseling with placebo (n = 12), or placebo alone (n = 8). The major differences in placental fatty acids were attributable to a higher concentration of n-3 polyunsaturated fatty acids in both intervention arms than in controls. Further, dietary counseling with probiotics resulted in higher concentrations of linoleic (18:2n-6) and dihomo-γ-linolenic acids (20:3n-6) compared with dietary counseling with placebo or controls.

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Fig. 1

Abbreviations

AA:

Arachidonic acid

DHA:

Docosahexaenoic acid

DHGA:

Dihomo-γ-linolenic acid

EPA:

Eicosapentaenoic acid

LA:

Linoleic acid

MUFA:

Monounsaturated fatty acid

PUFA:

Polyunsaturated fatty acid

SFA:

Saturated fatty acid

References

  1. Murphy VE, Smith R, Giles WB, Clifton VL (2006) Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev 27:141–169

    Article  PubMed  Google Scholar 

  2. Calder PC (2006) n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83:1505S–1519S

    PubMed  CAS  Google Scholar 

  3. Herrera E, Amusquivar E, López-Soldado I, Ortega H (2006) Maternal lipid metabolism and placental lipid transfer. Horm Res 65(Suppl 3):59–64

    Article  PubMed  CAS  Google Scholar 

  4. Szajewska H, Horvath A, Koletzko B (2006) Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am J Clin Nutr 83:1337–1344

    PubMed  CAS  Google Scholar 

  5. Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E (2001) Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357:1076–1079

    Article  PubMed  Google Scholar 

  6. Laitinen K, Kalliomäki M, Poussa T, Lagström H, Isolauri E (2005) Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years Br J Nutr 94:565–574

    Article  PubMed  CAS  Google Scholar 

  7. Kankaanpää PE, Salminen SJ, Isolauri E, Lee YK (2001) The influence of polyunsaturated fatty acids on probiotic growth and adhesion. FEMS Microbiol Lett 194:149–153

    Article  PubMed  Google Scholar 

  8. Piirainen T, Isolauri E, Lagström H, Laitinen K (2006) Impact of nutrition counseling on nutrient intake during pregnancy: a prospective cohort study. Br J Nutr 96:1095–1104

    Article  PubMed  CAS  Google Scholar 

  9. Rautava S, Kalliomaki M, Isolauri E (2005) New therapeutic strategy for combating the increasing burden of allergic disease: probiotics–a nutrition, allergy, mucosal immunology and intestinal microbiota (nami) research group report. J Allergy Clin Immunol 116:31–37

    Article  PubMed  Google Scholar 

  10. Becker W, Lyhne N, Pedersen AN, Aro A, Fogelhom M, Phorsdottir I, Alexander J, Anderssen SA, Meltzer HM, Pedersen JI (2004) Nordic nutrition recommendations 2004—integrating nutrition and physical activity. Scand J Nutr 48:178–187

    Article  Google Scholar 

  11. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509

    PubMed  CAS  Google Scholar 

  12. Hamilton JG, Comai K (1988) Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids 23:1146–1149

    Article  PubMed  CAS  Google Scholar 

  13. Laiho K, Lampi A, Hamalainen M, Moilanen E, Piironen V, Arvola T, Syrjanen S, Isolauri E (2003) Breast milk fatty acids, eicosanoids, and cytokines in mothers with and without allergic disease. Pediatr Res 53:642–647

    Article  PubMed  CAS  Google Scholar 

  14. Haggarty P (2002) Placental regulation of fatty acid delivery and its effect on fetal growth-a review. Placenta 23(Suppl A):S28–S38

    Article  PubMed  Google Scholar 

  15. Klingler M, Demmelmair H, Larqué E, Koletzko B (2003) Analysis of FA contents in individual lipid fractions from human placental tissue. Lipids 38:561–566

    Article  PubMed  CAS  Google Scholar 

  16. Nikkari T, Räsänen L, Viikari J, Akerblom HK, Vuori I, Pyörälä K, Uhari M, Dahl M, Lähde P, Pesonen E, Suoninen P (1983) Serum fatty acids in 8-year-old Finnish boys: correlations with qualitative dietary data and other serum lipids. Am J Clin Nutr 37:848–854

    PubMed  CAS  Google Scholar 

  17. Larqué E, Demmelmair H, Berger B, Hasbargen U, Koletzko B (2003) In vivo investigation of the placental transfer of (13)C-labeled fatty acids in humans. J Lipid Res 44:49–55

    Article  PubMed  CAS  Google Scholar 

  18. Kuhn DC, Crawford M (1986) Placental essential fatty acid transport and prostaglandin synthesis. Prog Lipid Res 25:345–353

    Article  PubMed  CAS  Google Scholar 

  19. Coleman RA, Haynes EB (1987) Synthesis and release of fatty acids by human trophoblast cells in culture. J Lipid Res 28:1335–1341

    PubMed  CAS  Google Scholar 

  20. Lakin V, Haggarty P, Abramovich DR, Ashton J, Moffat CF, McNeill G, Danielian PJ, Grubb D (1998) Dietary intake and tissue concentration of fatty acids in omnivore, vegetarian and diabetic pregnancy. Prostaglandins Leukot Essent Fatty Acids 59:209–220

    Article  PubMed  CAS  Google Scholar 

  21. Kankaanpää P, Yang B, Kallio H, Isolauri E, Salminen S (2004) Effects of polyunsaturated fatty acids in growth medium on lipid composition and on physicochemical surface properties of lactobacilli. Appl Environ Microbiol 70:129–136

    Article  PubMed  CAS  Google Scholar 

  22. Walker WA (2000) Role of nutrients and bacterial colonization in the development of intestinal host defense. J Pediatr Gastroenterol Nutr 30(Suppl 2):2–7

    Article  Google Scholar 

  23. Laitinen K, Hoppu U, Hämäläinen M, Linderborg K, Moilanen E, Isolauri E (2006) Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2, and fatty acids. Pediatr Res 59:723–727

    Article  PubMed  CAS  Google Scholar 

  24. Yu B, Hailman E, Wright SD (1997) Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids. J Clin Invest 99:315–324

    PubMed  CAS  Google Scholar 

  25. Goldblum SE, Brann TW, Ding X, Pugin J, Tobias PS (1994) Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro. J Clin Invest 93:692–702

    Article  PubMed  CAS  Google Scholar 

  26. Calder PC (2005) Polyunsaturated fatty acids and inflammation. Biochem Soc Trans 33:423–427

    Article  PubMed  CAS  Google Scholar 

  27. Fukushima M, Yamada A, Endo T, Nakano M (1999) Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat and cholesterol-enriched diet. Nutrition 15:373–378

    Article  PubMed  CAS  Google Scholar 

  28. Kankaanpää PE, Yang B, Kallio HP, Isolauri E, Salminen SJ (2002) Influence of probiotic supplemented infant formula on composition of plasma lipids in atopic infants. J Nutr Biochem 13:364–369

    Article  PubMed  Google Scholar 

  29. Yavin E (2006) Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. Prostaglandins Leukot Essent Fatty Acids 75:203–211

    Article  PubMed  CAS  Google Scholar 

  30. Buckley AJ, Jaquiery AL, Harding JE (2005) Nutritional programming of adult disease. Cell Tissue Res 322:73–79

    Article  PubMed  Google Scholar 

  31. Solomon CG, Carroll JS, Okamura K, Graves SW, Seely EW (1999) Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension. Am J Hypertens 12:276–282

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors thank the women who participated in this study, Satu Leinonen and Tanja Achrenius for laboratory assistance, and Robert MacGilleon for revision of the English text. Financial support from the Sigrid Jusélius Foundation, the Social Insurance Institution of Finland, and the Academy of Finland is gratefully acknowledged.

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Authors and Affiliations

  1. Functional Foods Forum, University of Turku, 20014, Turku, Finland

    Niina Kaplas & Kirsi Laitinen

  2. Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland

    Kirsi Laitinen

  3. Department of Paediatrics, University of Turku, Turku, Finland

    Erika Isolauri

  4. Department of Paediatrics, Turku University Central Hospital, Turku, Finland

    Erika Isolauri, Tiina Ojala & Kirsi Laitinen

  5. Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland

    Anna-Maija Lampi

Authors
  1. Niina Kaplas
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  2. Erika Isolauri
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  3. Anna-Maija Lampi
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  4. Tiina Ojala
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  5. Kirsi Laitinen
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Corresponding author

Correspondence to Kirsi Laitinen.

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11745_2007_3094_MOESM1_ESM.doc

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Kaplas, N., Isolauri, E., Lampi, AM. et al. Dietary Counseling and Probiotic Supplementation During Pregnancy Modify Placental Phospholipid Fatty Acids. Lipids 42, 865–870 (2007). https://doi.org/10.1007/s11745-007-3094-9

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  • DOI: https://doi.org/10.1007/s11745-007-3094-9

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