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Nutritional programming of adult disease

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Abstract

Intrauterine and early neonatal life is a period of physiological plasticity, during which environmental influences may produce long-term effects. Both undernutrition and overnutrition during this period have been shown to change disease risk in adulthood. These effects are influenced by the type, timing and duration of inappropriate nutrition and by the previous nutritional environment and may not be reflected in changes in body size. An understanding of the interaction between nutrient imbalance and alteration of gene expression is likely to be the key to optimising future health outcomes.

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  1. Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand

    Alex J. Buckley, Anne L. Jaquiery & Jane E. Harding

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  1. Alex J. Buckley
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  2. Anne L. Jaquiery
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  3. Jane E. Harding
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Correspondence to Jane E. Harding.

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Buckley, A.J., Jaquiery, A.L. & Harding, J.E. Nutritional programming of adult disease. Cell Tissue Res 322, 73–79 (2005). https://doi.org/10.1007/s00441-005-1095-7

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