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Dietary fatty acids early in life affect lipid metabolism and adiposity in young rats

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Lipids

Abstract

The purpose of this study was to evaluate the effects of four isoenergetic diets of differing fat composition on blood lipid profile and adiposity in young rats. Diets containing different lipid sources—partially hydrogenated vegetable oil (PHVO), palm oil (PO), canola oil (CO), and soy oil (SO)—were fed to lactating rats during the 21 days of lactation, and then fed to young males following weaning until the 45th, day of life. In vivo lipogenesis rate (LR), lipid content (LC), relative level of FA, and the activity of lipoprotein lipase (LPL) enzyme were measured in epididymal adipose tissue (EPI). Fasting blood lipoproteins and LC in the carcass were also appraised. Body weight of PO and PHVO groups was significantly higher than CO and SO groups from day 14 of lactation to day 45, despite the lower food intake in the PHVO group. PO and PHVO groups presented higher LR and LC in EPI than SO and CO groups. Carcass fat content was significantly higher in PHVO and PO groups than in CO and SO groups. The LPL activity in EPI was unaffected by dietary lipids. PHVO group had increased total cholesterol and TAG concentrations in comparison with the PO group, and significantly lower HDL level compared with the other groups. These results show that the kind of FA in the dietary lipid offered early in life can affect lipid metabolism and adiposity.

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Abbreviations

AA:

arachidonic acid

CO:

canola oil

EPI:

epididymal adipose tissue

LPL:

lipoprotein lipase

LR:

lipogenesis rate

MUFA:

monounsaturated FA

PHVO:

partially hydrogenated vegetable oil

PO:

palm oil

PUFA:

polyunsaturated FA

SFA:

saturated FA

SO:

soy oil

TC:

total cholesterol

tFA:

trans FA

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Authors and Affiliations

  1. Instituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 2o andar, 21.941-590, Rio de Janeiro, Brazil

    Ana Paula S. Silva, Daniella E. D. Guimarães, Daniella M. Mizurini, Ingrid C. Maia, Susana Ortiz-Costa, Fátima L. Sardinha & Maria G. Tavares do Carmo

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  1. Ana Paula S. Silva
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  2. Daniella E. D. Guimarães
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  3. Daniella M. Mizurini
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  4. Ingrid C. Maia
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  5. Susana Ortiz-Costa
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  6. Fátima L. Sardinha
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  7. Maria G. Tavares do Carmo
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Correspondence to Maria G. Tavares do Carmo.

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Silva, A.P.S., Guimarães, D.E.D., Mizurini, D.M. et al. Dietary fatty acids early in life affect lipid metabolism and adiposity in young rats. Lipids 41, 535–541 (2006). https://doi.org/10.1007/s11745-006-5002-0

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  • DOI: https://doi.org/10.1007/s11745-006-5002-0

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