Skip to main content
SpringerLink
Log in

Impact of dietary n−3 FA deficiency on rat bone tissue FA composition

  • Communication
  • Published:
Lipids

Abstract

The effect of dietary n−3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n−3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n−3 treatments were formulated with added α-linolenic acid (LNA) from flaxseed oil (diet LNA) or LNA plus DHA, and both were balanced for LA. This study showed that bone is sensitive to changes in dietary n−3 FA and that DHA is more effective than LNA in maintaining DHA levels in these tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

AA:

arachidonic acid

LA:

linoleic acid

LNA:

α-linolenic acid

n−3LC :

sum of 20∶5n−3+22∶6n−3+22∶6n−3

n−6LC :

sum of 20∶4n−6+22∶4n−6+22∶5n−6

NIAAA:

National Institute on Alcohol Abuse and Alcoholism

PGE2 :

prostaglandin E2

References

  1. Watkins, B.A., Li, Y., Allen, K.G.D., Hoffmann, W.E., and Seifert, M.F. (2000) Dietary Ratio of (n−6)/(n−3) Polyunsaturated Fatty Acids Alters the Fatty Acid Composition of Bone Compartments and Biomarkers of Bone Formation in Rats, J. Nutr. 130, 2274–2284.

    PubMed  CAS  Google Scholar 

  2. Watkins, B.A., Lippman, H.E., Le Bouteiller, L., Li, Y., and Seifert, M.F. (2001) Bioactive Fatty Acids: Role in Bone Biology and Bone Cell Function, Prog. Lipid Res. 40, 125–148.

    Article  PubMed  CAS  Google Scholar 

  3. Greiner, R.S., Moriguchi, T., Slotnick, B.M., Hutton, A., and Salem, N. (2001) Olfactory Discrimination Deficits in n−3 Fatty Acid-Deficient Rats, Physiol. Behav. 72, 379–385.

    Article  PubMed  CAS  Google Scholar 

  4. Murthy, M., Hamilton, J., Greiner, R.S., Moriguchi, T., Salem, N., Jr., and Kim, H.Y. (2002) Differential Effects of n−3 Fatty Acid Deficiency on Phospholipid Molecular Species Composition in the Rat Hippocampus, J. Lipid Res. 43, 611–617.

    PubMed  CAS  Google Scholar 

  5. Li, Y., Seifert, M.F., Ney, D.M., Grahn, M., Grant, A.L., Allen, K.G., and Watkins, B.A. (1999) Dietary Conjugated Linoleic Acids Alter Serum IGF-I and IGF Binding Protein Concentrations and Reduce Bone Formation in Rats Fed (n−6) or (n−3) FA, J. Bone Miner. Res. 14, 1153–1162.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, 47907, West Lafayette, Indiana

    Yong Li & Bruce A. Watkins

  2. Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, 20852, Rockville, Maryland

    Rebecca S. Greiner & Norman Salem Jr.

Authors
  1. Yong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rebecca S. Greiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Norman Salem Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bruce A. Watkins
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bruce A. Watkins.

About this article

Cite this article

Li, Y., Greiner, R.S., Salem, N. et al. Impact of dietary n−3 FA deficiency on rat bone tissue FA composition. Lipids 38, 683–686 (2003). https://doi.org/10.1007/s11745-003-1115-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11745-003-1115-8

Keywords

Search

Navigation