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The effect of n−3 fatty acids on low density lipoprotein subfractions

  • Published:
Lipids

Abstract

A predominance of small, dense low density lipoprotein (LDL) represents a significant source of increased risk for the development of coronary heart disease in Westernized countries. Dietary long-chain n−3 polyunsaturated fatty acids exert a potent triglyceride-lowering effect that redistributes LDL subfractions toward larger and lighter particles. These dietary fatty acids thus have a key role to play in providing protection against this particularly atherogenic type of LDL.

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Abbreviations

ALP:

atherogenic lipoprotein phenotype

apo:

apolipoprotein

AUC:

area under the curve

C:

cholesterol

CETP:

cholesteryl ester transfer protein

CHD:

coronary heart disease

CM:

chylomicrons

CMR:

chylomicron remnant

HDL:

high density lipoprotein

HTG:

hypertriglyceridemia

IAUC:

incremental area under the curve

LDL:

low density lipoprotein

LPL:

lipoprotein lipase

NEFA:

nonesterified fatty acids

PUFA:

polyunsaturated fatty acids

TAG:

triacylglycerols

VLDL:

very low density lipoprotein

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  1. Centre for Nutrition & Food Safety, School of Biomedical & Life Sciences, University of Surrey, Guildford, GU2 7XH, Surrey, UK

    Bruce A. Griffin

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Correspondence to Bruce A. Griffin.

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Griffin, B.A. The effect of n−3 fatty acids on low density lipoprotein subfractions. Lipids 36 (Suppl 1), S91–S97 (2001). https://doi.org/10.1007/s11745-001-0688-6

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  • DOI: https://doi.org/10.1007/s11745-001-0688-6

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