Micellization of Some Bile Salts in Binary Aqueous Solvent Mixtures

Abstract

The micellization behavior of bile salts—sodium cholate and sodium deoxycholate was studied in aqueous methanol, ethanol and ethylene glycol mixtures (10–20 % v/v) over a temperature range (300–320 K) by surface tension and conductivity methods. Critical micelle concentration, extent of counter ion binding (α), interfacial property (A _min, ζ_max, π-CMC, $\Updelta G_{\text{ad}}^{ \circ }$) and thermodynamic parameters ($\Updelta G_{\text{m}}^{ \circ }$, $\Updelta H_{\text{m}}^{ \circ }$, $\Updelta S_{\text{m}}^{ \circ }$) for the micellization process are reported and discussed.