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Microsphere-integrated gelatin-siloxane hybrid scaffolds for bone tissue engineering: in vitro bioactivity & antibacterial activity

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Abstract

Microsphere integrated gelatin-siloxane hybrid scaffolds were successfully synthesized by using a combined sol-gel processing, post-gelation soaking and freeze-drying process. A bone-like apatite layer was able to form in the Ca2+-containing porous hybrids upon soaking in a simulated body fluid (SBF) up to 1 day. The rate of gentamicin sulfate (GS) release from the GS-loaded gelatin-siloxane hybrid microsphere became constant after a 4 h burst. The antibacterial activity was assessed by the agar diffusion test (ADT) and the bactericidal effect test. It is evident that the as-synthesized porous scaffolds have excellent bioactivity and antibacterial activity, and may be favorable in bone tissue engineering.

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Authors and Affiliations

  1. Research Center of Biomedical Engineering, College of Materials, Xiamen University, Xiamen, 361005, China

    Lin Wang, Bing Yu, Li-ping Sun, Lei Ren & Qi-qing Zhang

  2. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China

    Qi-qing Zhang

Authors
  1. Lin Wang
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  2. Bing Yu
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  3. Li-ping Sun
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  4. Lei Ren
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  5. Qi-qing Zhang
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Correspondence to Lei Ren or Qi-qing Zhang.

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Wang, L., Yu, B., Sun, Lp. et al. Microsphere-integrated gelatin-siloxane hybrid scaffolds for bone tissue engineering: in vitro bioactivity & antibacterial activity. Front. Mater. Sci. China 2, 172–178 (2008). https://doi.org/10.1007/s11706-008-0029-1

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  • DOI: https://doi.org/10.1007/s11706-008-0029-1

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