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An Opioid-Sparing Protocol Improves Recovery Time and Reduces Opioid Use After Laparoscopic Sleeve Gastrectomy

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Abstract

Purpose

The current literature is sparse on post discharge pain management for bariatric surgical patients. This study aimed to determine if an opioid-sparing protocol could decrease opioid use during the postoperative period (hospital to home).

Materials and Methods

In this retrospective cohort study, we implemented an opioid-sparing protocol in January 2018, for patients undergoing laparoscopic sleeve gastrectomy (LSG) at our institution. We compared recovery time, pain scores (in hospital and at home), and perioperative opioid use between the historic control group (February 2017 to December 2017) and the opioid-sparing group (January 2018 to December 2018). A p value of < .05 was considered statistically significant.

Results

The study included 400 patients (200 in each group), and 165 participated in the phone survey. Baseline characteristics were similar, except the control group had a higher body mass index and body weight. The average recovery time was significantly shorter in the opioid-sparing group (18.9 versus 35.3 days, P = .043). There was no significant difference in mean postoperative pain scores in the hospital or at home. The opioid-sparing group required significantly fewer opioids postoperatively (10.4 versus 16.1 morphine milligram equivalents, P < .001). Only 1 out of the 200 patients in the opioid-sparing arm requested an opioid prescription after discharge.

Conclusion

Implementation of an opioid-sparing protocol improved recovery time and reduced postoperative opioid use in the hospital and after discharge without changing perceived pain in patients undergoing LSG.

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Abbreviations

MBSAQIP:

Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program

References

  1. Hill MV, McMahon ML, Stucke RS, et al. Wide variation and excessive dosage of opioid prescriptions for common general surgical procedures. Ann Surg. 2017;265(4):709–14. https://doi.org/10.1097/SLA.0000000000001993.

    Article  PubMed  Google Scholar 

  2. Bicket MC, Long JJ, Pronovost PJ, et al. Prescription opioid analgesics commonly unused after surgery: a systematic review. JAMA Surg. 2017;152(11):1066–71. https://doi.org/10.1001/jamasurg.2017.0831.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Friedman DT, Ghiassi S, Hubbard MO, et al. Postoperative opioid prescribing practices and evidence-based guidelines in bariatric surgery. Obes Surg. 2019;29(7):2030–6. https://doi.org/10.1007/s11695-019-03821-8.

    Article  PubMed  Google Scholar 

  4. Chen EY, Marcantonio A, Tornetta 3rd P. Correlation between 24-hour predischarge opioid use and amount of opioids prescribed at hospital discharge. JAMA Surg. 2018;153(2):174859. https://doi.org/10.1001/jamasurg.2017.4859.

    Article  Google Scholar 

  5. Brethauer SA, Grieco A, Fraker T, et al. Employing enhanced recovery goals in bariatric surgery (ENERGY): a national quality improvement project using the metabolic and bariatric surgery accreditation and quality improvement program. Surg Obes Relat Dis. 2019;15(11):1977–89. https://doi.org/10.1016/j.soard.2019.08.024.

    Article  PubMed  Google Scholar 

  6. Ahmed OS, Rogers AC, Bolger JC, et al. Meta-analysis of enhanced recovery protocols in bariatric surgery. J Gastrointest Surg. 2018;22(6):964–72. https://doi.org/10.1007/s11605-018-3709-x.

    Article  PubMed  Google Scholar 

  7. Thorell A, MacCormick AD, Awad S, et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg. 2016;40(9):2065–83. https://doi.org/10.1007/s00268-016-3492-3.

    Article  CAS  PubMed  Google Scholar 

  8. Ng JJ, Leong WQ, Tan CS, et al. A multimodal analgesic protocol reduces opioid-related adverse events and improves patient outcomes in laparoscopic sleeve gastrectomy. Obes Surg. 2017;27(12):3075–81. https://doi.org/10.1007/s11695-017-2790-7.

    Article  PubMed  Google Scholar 

  9. Smith ME, Lee JS, Bonham A, et al. Effect of new persistent opioid use on physiologic and psychologic outcomes following bariatric surgery. Surg Endosc. 2019;33(8):2649–56. https://doi.org/10.1007/s00464-018-6542-0.

    Article  PubMed  Google Scholar 

  10. King WC, Chen JY, Belle SH, et al. Use of prescribed opioids before and after bariatric surgery: prospective evidence from a U.S. multicenter cohort study. Surg Obes Relat Dis. 2017;13(8):1337–46. https://doi.org/10.1016/j.soard.2017.04.003.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Horsley RD, Vogels ED, McField DAP, et al. Multimodal postoperative pain control is effective and reduces opioid use after laparoscopic roux-en-Y gastric bypass. Obes Surg. 2019;29(2):394–400. https://doi.org/10.1007/s11695-018-3526-z.

    Article  PubMed  Google Scholar 

  12. Saurabh S, Smith JK, Pedersen M, et al. Scheduled intravenous acetaminophen reduces postoperative narcotic analgesic demand and requirement after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2015;11(2):424–30. https://doi.org/10.1016/j.soard.2014.09.017.

    Article  PubMed  Google Scholar 

  13. Song K, Melroy MJ, Whipple OC. Optimizing multimodal analgesia with intravenous acetaminophen and opioids in postoperative bariatric patients. Pharmacotherapy. 2014;34(Suppl 1):14S–21S. https://doi.org/10.1002/phar.1517.

    Article  CAS  PubMed  Google Scholar 

  14. Strode MA, Sherman W, Mangieri CW, et al. Randomized trial of OFIRMEV versus placebo for pain management after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2016;12(4):772–7. https://doi.org/10.1016/j.soard.2015.08.512.

    Article  PubMed  Google Scholar 

  15. Ziemann-Gimmel P, Hensel P, Koppman J, et al. Multimodal analgesia reduces narcotic requirements and antiemetic rescue medication in laparoscopic Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2013;9(6):975–80. https://doi.org/10.1016/j.soard.2013.02.003.

    Article  PubMed  Google Scholar 

  16. Bamgbade OA, Oluwole O, Khaw RR. Perioperative analgesia for fast-track laparoscopic bariatric surgery. Obes Surg. 2017;27(7):1828–34. https://doi.org/10.1007/s11695-017-2562-4.

    Article  PubMed  Google Scholar 

  17. King AB, Spann MD, Jablonski P, et al. An enhanced recovery program for bariatric surgical patients significantly reduces perioperative opioid consumption and postoperative nausea. Surg Obes Relat Dis. 2018;14(6):849–56. https://doi.org/10.1016/j.soard.2018.02.010.

    Article  PubMed  Google Scholar 

  18. Mark J, Argentieri DM, Gutierrez CA, et al. Ultrarestrictive opioid prescription protocol for pain management after gynecologic and abdominal surgery. JAMA Netw Open. 2018;1(8):e185452. https://doi.org/10.1001/jamanetworkopen.2018.5452.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Howard R, Waljee J, Brummett C, et al. Reduction in opioid prescribing through evidence-based prescribing guidelines. JAMA Surg. 2018;153(3):285–7. https://doi.org/10.1001/jamasurg.2017.4436.

    Article  PubMed  Google Scholar 

  20. Overton HN, Hanna MN, Bruhn WE, et al. Opioid-prescribing guidelines for common surgical procedures: an expert panel consensus. J Am Coll Surg. 2018;227(4):411–8. https://doi.org/10.1016/j.jamcollsurg.2018.07.659.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Wick EC, Grant MC, Wu CL. Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques: a review. JAMA Surg. 2017;152(7):691–7. https://doi.org/10.1001/jamasurg.2017.0898.

    Article  PubMed  Google Scholar 

  22. Stowers MD, Lemanu DP, Hill AG. Health economics in enhanced recovery after surgery programs. Can J Anaesth. 2015;62(2):219–30. https://doi.org/10.1007/s12630-014-0272-0.

    Article  PubMed  Google Scholar 

  23. US Drug Enforcement Agency (DEA). Schedules of controlled substances: placement of tramadol into schedule IV. Published July 2, 2014. Accessed February 7, 2020 at https://www.deadiversion.usdoj.gov/fed_regs/rules/2014/fr0702.htm.

  24. Hickman SR, Mathieson KM, Bradford LM, et al. Randomized trial of oral versus intravenous acetaminophen for postoperative pain control. Am J Health Syst Pharm. 2018;75(6):367–75. https://doi.org/10.2146/ajhp170064.

    Article  PubMed  Google Scholar 

  25. Jibril F, Sharaby S, Mohamed A, et al. Intravenous versus oral acetaminophen for pain: systematic review of current evidence to support clinical decision-making. Can J Hosp Pharm. 2015;68(3):238–47. https://doi.org/10.4212/cjhp.v68i3.1458.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to William J. Suggs.

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Appendix

Appendix

Table 4 Phone survey questions

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Pardue, B., Thomas, A., Buckley, J. et al. An Opioid-Sparing Protocol Improves Recovery Time and Reduces Opioid Use After Laparoscopic Sleeve Gastrectomy. OBES SURG 30, 4919–4925 (2020). https://doi.org/10.1007/s11695-020-04980-9

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