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Changes in Body Composition and Biochemical Parameters Following Laparoscopic One Anastomosis Gastric Bypass: 1-Year Follow-Up

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Abstract

Background/Aim

Little data is available on body composition and biochemical parameter changes after one anastomosis gastric bypass (OAGB) surgery. This study was therefore conducted to assess body composition and biochemical parameter changes in patients who underwent OAGB. The relationship between the percentage of total weight loss (%TWL) with percentage changes in body composition and biochemical parameters was measured in the first year after surgery.

Materials and Methods

This retrospective study was carried out on 363 patients (mean age 39.93 ± 9.98 years) who underwent OAGB between January 2011 and November 2018. Anthropometric, body composition and biochemical measurements were recorded before and 1 year after surgery. For paired data, a paired sample t test or Wilcoxon test was used. Spearman or Pearson correlation test was used to evaluate the relationship between % TWL and changes in body composition and biochemical parameters.

Results

The average %TWL at 1 year following surgery was 35.72 ± 6.85. Fat and muscle tissue and also serum levels of glycemic parameters, low density lipoprotein, triglycerides (TG), total cholesterol, zinc, albumin, hemoglobin, hematocrit, and platelet had decreased a year after OAGB (P < 0.05). The postoperative levels of HDL-c, vitamins D, B12, and folic acid were dramatically higher than the preoperative values. Higher %TWL significantly correlated to greater decreases in body fat, muscle mass, and serum TG at 1 year post-surgery, compared to preoperative values.

Conclusion

OAGB may be effective over a follow-up period of 1 year in achieving weight, fat mass reduction, and improved serum levels of glycemic parameters and lipid profiles.

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References

  1. Carbajo MA, Fong-Hirales A, Luque-de-Leon E, et al. Weight loss and improvement of lipid profiles in morbidly obese patients after laparoscopic one-anastomosis gastric bypass: 2-year follow-up. Surg Endosc. 2017;31(1):416–21.

    Article  Google Scholar 

  2. Lee WJ, Wang W, Lee YC, et al. Effect of laparoscopic mini-gastric bypass for type 2 diabetes mellitus: comparison of BMI>35 and <35 kg/m2. J Gastrointest Surg. 2008;12(5):945–52.

    Article  Google Scholar 

  3. Arble DM, Evers SS, Bozadjieva N, et al. Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat. Surg Obes Relat Dis. 2018;14(12):1857–67.

    Article  Google Scholar 

  4. Solouki A, Kermansaravi M, Davarpanah Jazi AH, et al. One-anastomosis gastric bypass as an alternative procedure of choice in morbidly obese patients. J Res Med Sci. 2018;23:84.

    Article  Google Scholar 

  5. Lee WJ, Ser KH, Lee YC, et al. Laparoscopic Roux-en-Y vs. mini-gastric bypass for the treatment of morbid obesity: a 10-year experience. Obes Surg. 2012;22(12):1827–34.

    Article  Google Scholar 

  6. Plamper A, Lingohr P, Nadal J, et al. Comparison of mini-gastric bypass with sleeve gastrectomy in a mainly super-obese patient group: first results. Surg Endosc. 2017;31:1156–62.

    Article  Google Scholar 

  7. Vaurs C, Dimeglio C, Charras L, et al. Determinants of changes in muscle mass after bariatric surgery. Diabetes Metab. 2015;41(5):416–21.

    Article  CAS  Google Scholar 

  8. Garciacaballero M, Reyes-Ortiz A, García Sillero M, et al. Changes of body composition in patients with BMI 23-50 after tailored one anastomosis gastric bypass (BAGUA): influence of diabetes and metabolic syndrome. Obes Surg. 2014;24(12):2040–7.

    Article  CAS  Google Scholar 

  9. Rutledge R, Walsh TR. Continued excellent results with the mini-gastric bypass: six-year study in 2,410 patients. Obes Surg. 2005;15(9):1304–8.

    Article  Google Scholar 

  10. Khalaj A, Kalantar Motamedi MA, Mousapour P, et al. Protein-calorie malnutrition requiring revisional surgery after one-anastomosis-mini-gastric bypass (OAGB-MGB): case series from the Tehran Obesity Treatment Study (TOTS). Obes Surg. 2019;29(6):1714–20.

    Article  Google Scholar 

  11. Kessler Y, Adelson D, Mardy-Tilbor L, Ben-Porat T, Szold A, Goitein D, et al. Nutritional status following one anastomosis gastric bypass. Clin Nutr. 2019.

  12. van Rutte P, Aarts E, Smulders J, Nienhuijs S. Nutrient deficiencies before and after sleeve gastrectomy. Obes Surg. 2014;24.

  13. Arias PM, Domeniconi EA, Garcia M, et al. Micronutrient deficiencies after Roux-en-Y gastric bypass: long-term results. Obes Surg. 2020;30(1):169–73.

    Article  Google Scholar 

  14. Milone M, Lupoli R, Maietta P, et al. Lipid profile changes in patients undergoing bariatric surgery: a comparative study between sleeve gastrectomy and mini-gastric bypass. Int J Surg. 2015;14:28–32.

    Article  Google Scholar 

  15. Bagheri M, Talebpour M, Sharifi A, et al. Lipid profile change after bariatric surgeries: laparoscopic gastric plication versus mini gastric bypass. Acta Chir Belg. 2018;119:1–6.

    Google Scholar 

  16. Zamaninour N, Ansar H, Pazouki A, et al. Relationship between modified body adiposity index and A body shape index with biochemical parameters in bariatric surgery candidates. Obes Surg. 2020;30(3):901–9.

    Article  Google Scholar 

  17. Ansar H, Zamaninour N, Pazouki A, et al. Weight loss after one anastomosis gastric bypass-mini gastric bypass (OAGB-MGB): patient-related perioperative predictive factors. Obes Surg. 2019;30(4):1316–23.

    Article  Google Scholar 

  18. Carbajo MA, Jimenez JM, Luque-de-Leon E, et al. Evaluation of weight loss indicators and laparoscopic one-anastomosis gastric bypass outcomes. Sci Rep. 2018;8(1):1961.

    Article  Google Scholar 

  19. Abdeen G, le Roux CW. Mechanism underlying the weight loss and complications of Roux-en-Y gastric bypass. Review. Obes Surg. 2016;26(2):410–21.

    Article  CAS  Google Scholar 

  20. Koopman R, Ly CH, Ryall JG. A metabolic link to skeletal muscle wasting and regeneration. Front Physiol. 2014;5:32.

    Article  Google Scholar 

  21. Marks BL, Rippe JM. The importance of fat free mass maintenance in weight loss programmes. Sports Med. 1996;22(5):273–81.

    Article  CAS  Google Scholar 

  22. Cava E, Yeat NC, Mittendorfer B. Preserving healthy muscle during weight loss. Adv Nutr. 2017;8(3):511–9.

    Article  CAS  Google Scholar 

  23. Angrisani L, Vitiello A, Hasani A, et al. Endpoint of bariatric surgery is not only preservation of free fat mass but restoration of normal body composition. Obes Surg. 2017;27(6):1633–4.

    Article  Google Scholar 

  24. Maïmoun L, Lefebvre P, Aouinti S, et al. Acute and longer-term body composition changes after bariatric surgery. Surg Obes Relat Dis. 2019;15(11):1965–73.

    Article  Google Scholar 

  25. Palacio A, Quintiliano D, Lira I, et al. Changes in body composition in patients following bariatric surgery: gastric bypass and sleeve gastrectomy. Nutr Hosp. 2019;36(2):334–49.

    PubMed  Google Scholar 

  26. Omar W, Elhoofy A, Abdelbaky M. Bariatric surgery and its role in the management of metabolic syndrome. Egypt J Surg. 2019;38(2):257–66.

    Google Scholar 

  27. Heffron SP, Parikh A, Volodarskiy A, et al. Changes in lipid profile of obese patients following contemporary bariatric surgery: a meta-analysis. Am J Med. 2016;129(9):952–9.

    Article  CAS  Google Scholar 

  28. Penney NC, Kinross J, Newton RC, et al. The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic commenw. Int J Obes. 2015;39(11):1565–74.

    Article  CAS  Google Scholar 

  29. Laferrère B, Pattou F. Weight-independent mechanisms of glucose control after Roux-en-Y gastric bypass. Front Endocrinol (Lausanne). 2018;9:530.

    Article  Google Scholar 

  30. Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition (Burbank, Los Angeles County, Calif). 2010;26(11–12):1031–7.

    Article  CAS  Google Scholar 

  31. Lupoli R, Lembo E, Saldalamacchia G, et al. Bariatric surgery and long-term nutritional issues. World J Diabetes. 2017;8(11):464–74.

    Article  Google Scholar 

  32. Aaseth E, Fagerland MW, Aas AM, et al. Vitamin concentrations 5 years after gastric bypass. Eur J Clin Nutr. 2015;69(11):1249–55.

    Article  CAS  Google Scholar 

  33. Kermansaravi M, Abdolhosseini MR, Kabir A, et al. Severe hypoalbuminemia and steatohepatitis leading to death in a young vegetarian female, 8 months after mini gastric bypass: a case report. Int J Surg Case Rep. 2017;31:17–9.

    Article  Google Scholar 

  34. Motamedi MAK, Barzin M, Ebrahimi M, et al. Severe fatal protein malnutrition and liver failure in a morbidly obese patient after mini-gastric bypass surgery: case report. Int J Surg Case Rep. 2017;33:71–4.

    Article  Google Scholar 

  35. Chen M, Krishnamurthy A, Mohamed AR, et al. Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation. Biomed Res Int. 2013;2013:205467.

    PubMed  PubMed Central  Google Scholar 

  36. Johansson H-E, Wåhlén A, Aldenbäck E, et al. Platelet counts and liver enzymes after gastric bypass surgery. Obes Surg. 2018;28(6):1526–31.

    Article  Google Scholar 

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Acknowledgments

The authors extend their sincere thanks to all participants and National Obesity Surgery Database team, who prepared us very useful data.

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

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Authors and Affiliations

  1. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Mansouri Alley, Niyayesh St.; Sattarkhan St, Tehran, Iran

    Negar Zamaninour, Abdolreza Pazouki, Mohammad Kermansaravi & Ali Kabir

  2. Center of Excellence of European Branch, International Federation for Surgery of Obesity, Tehran, Iran

    Abdolreza Pazouki & Mohammad Kermansaravi

  3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Atefeh Seifollahi

Authors
  1. Negar Zamaninour
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  2. Abdolreza Pazouki
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  3. Mohammad Kermansaravi
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  4. Atefeh Seifollahi
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  5. Ali Kabir
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Corresponding author

Correspondence to Ali Kabir.

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The authors declare that they have no conflict of interest.

Ethics and Consent

This study was conducted in accordance with the Helsinki declaration and approved by the Research Ethics committee (Ethics number: IR.IUMS.REC 1395.95-03-140-28809). Written informed consent form was received from all patients at the time of first registry in our database for any possible anonymous usage from their data.

Informed Consent

Written informed consent form was received from all patients at the time of first registry in our database for any possible anonymous usage from their data.

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Zamaninour, N., Pazouki, A., Kermansaravi, M. et al. Changes in Body Composition and Biochemical Parameters Following Laparoscopic One Anastomosis Gastric Bypass: 1-Year Follow-Up. OBES SURG 31, 232–238 (2021). https://doi.org/10.1007/s11695-020-04901-w

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  • DOI: https://doi.org/10.1007/s11695-020-04901-w

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