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Efficacy and Safety of Endoscopic Sleeve Gastroplasty at Mid Term in the Management of Overweight and Obese Patients: a Systematic Review and Meta-Analysis

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Abstract

Background

Endoscopic sleeve gastroplasty (ESG) has emerged as a promising technique in endoscopic bariatric and metabolic therapies (EBMTs). We aimed to perform a systematic review and meta-analysis to provide an update on its efficacy and safety.

Methods

This is a systematic review and meta-analysis was performed following the PRISMA guidelines. MEDLINE, Cochrane, EMBASE, and LILACS were searched to identify the studies related to ESG.

Results

Eleven studies with a total of 2170 patients were included. The average BMI pre-ESG was 35.78 kg/m2. Pooled mean %TWL observed at 6, 12, and 18 months was 15.3%, 16.1%, and 16.8% respectively. Pooled mean %EWL at 6, 12, and 18 months was 55.8%, 60%, and 73% respectively. No procedure-related mortality was reported.

Conclusion

ESG is a safe and effective procedure for primary obesity therapy with promising short- and mid-term results.

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Authors and Affiliations

  1. Gastrointestinal Endoscopy Unit, Hospital das Clínicas, University of Sao Paulo School of Medicine, São Paulo, Brazil

    Antonio Afonso de Miranda Neto, Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro, Alberto Machado da Ponte Neto, Antonio Coutinho Madruga Neto, Epifanio Silvino do Monte Junior, Wanderley Marques Bernardo & Eduardo Guimarães Hourneaux de Moura

  2. Department of Medicine, West Virginia University Health Sciences Center Charleston Division, Charleston, WV, USA

    Ahmad Khan

  3. Division of Gastroenterology, West Virginia University Health Sciences Center Charleston Division, Charleston, WV, USA

    Shailendra Singh

  4. Gastroenterology Unit, Hospital das Clínicas, University of Sao Paulo School of Medicine, São Paulo, Brazil

    Francisco Tustumi

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  1. Antonio Afonso de Miranda Neto
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Contributions

Miranda Neto, AAM: acquisition of data, analysis, interpretation of data, drafting the article, revising the article, final approval. Moura, DTH: analysis and interpretation of data, revising the article. Ribeiro, IB: acquisition of data, drafting the article, revising the article, final approval. Khan, A: analysis and interpretation of data, drafting the article, final approval. Shailendra, S: revising, editing and drafting article, final approval. Ponte Neto, AM: revising, editing and drafting article, final approval. Madruga Neto, AC: revising, editing and drafting article, final approval. Monte Junior, ES: revising, editing and drafting article, final approval. Tustumi, F: revising, editing and drafting article, final approval. Bernardo, WM: revising, editing and drafting article, final approval. de Moura, EGH: analysis and interpretation of data, drafting the article, revising the article, final approval.

Corresponding author

Correspondence to Igor Braga Ribeiro.

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Conflict of Interest

Dr. Moura reports personal fees from Boston Scientific, personal fees from Olympus, outside the submitted work.

Ethical Statement

The study was approved by the Research Ethics Committee of the University of São Paulo School of Medicine Hospital das Clínicas.

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Informed written consent was obtained from all participants.

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de Miranda Neto, A.A., de Moura, D.T.H., Ribeiro, I.B. et al. Efficacy and Safety of Endoscopic Sleeve Gastroplasty at Mid Term in the Management of Overweight and Obese Patients: a Systematic Review and Meta-Analysis. OBES SURG 30, 1971–1987 (2020). https://doi.org/10.1007/s11695-020-04449-9

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