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Obesity and Inflammation: Change in Adiponectin, C-Reactive Protein, Tumour Necrosis Factor-Alpha and Interleukin-6 After Bariatric Surgery

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Abstract

Background

Obesity is associated with a low-grade inflammatory state. A causal association between inflammation and atherosclerosis has been suggested. The aim of this study was to evaluate changes in the proinflammatory profile of morbidly obese patients after weight loss following bariatric surgery.

Methods

In this study, we measured levels of adiponectin, high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) and their relation to insulin resistance and lipid parameters in 60 morbidly obese women at baseline and 3, 6 and 12 months after gastric bypass.

Results

Twelve months after surgery, there was a significant increase in plasma levels of adiponectin (p < 0.001) and high-density lipoprotein cholesterol (p < 0.01) and a significant decrease in levels of IL-6 (p < 0.001), hs-CRP (p < 0.001), cholesterol (p < 0.001), triglycerides (p < 0.001), low-density lipoprotein cholesterol (p < 0.001), glucose (p < 0.001), insulin (p < 0.001) and homeostasis model assessment (HOMA; p < 0.001). At 12 months, correlations were seen between IL-6 levels and the following: body mass index (BMI) (r = 0.53, p < 0.001), insulin (r = 0.51, p < 0.001) and HOMA (r = 0.55, p < 0.001). Also, hs-CRP levels correlated with BMI (r = 0.40, p = 0. 004), triglycerides (r = 0.34, p = 0.017), insulin (r = 0.50, p = 0.001) and HOMA (r = 0.46, p = 0.002).

Conclusions

In patients with morbid obesity, significant weight loss is followed by a significant improvement in the inflammatory state, insulin sensitivity and lipid profile. A relationship exists between improved inflammatory profile and insulin sensitivity.

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Conflict of interest

Fátima Illán Gómez, Manuel Gonzálvez Ortega, Isabel Orea Soler, Ma. Soledad Alcaraz Tafalla, Aurora Aragón Alonso, Mercedes Pascual Díaz, Matías Pérez Paredes, Ma. Luisa Lozano Almela declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Endocrinology and Nutrition, University Hospital Morales Meseguer, C/ Marques de los Velez s/n 30008, Murcia, Spain

    Fátima Illán-Gómez, Isabel Orea-Soler, Ma. Soledad Alcaraz-Tafalla, Aurora Aragón-Alonso & Mercedes Pascual-Díaz

  2. Department of Cardiology, University Hospital Morales Meseguer, C/ Marques de los Velez s/n 30008, Murcia, Spain

    Manuel Gonzálvez-Ortega & Matías Pérez-Paredes

  3. Department of Hematology, University Hospital Morales Meseguer, C/Marques de los Velez s/n 30008, Murcia, Spain

    Ma. Luisa Lozano-Almela

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  1. Fátima Illán-Gómez
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Correspondence to Fátima Illán-Gómez.

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Illán-Gómez, F., Gonzálvez-Ortega, M., Orea-Soler, I. et al. Obesity and Inflammation: Change in Adiponectin, C-Reactive Protein, Tumour Necrosis Factor-Alpha and Interleukin-6 After Bariatric Surgery. OBES SURG 22, 950–955 (2012). https://doi.org/10.1007/s11695-012-0643-y

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