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Moringa concanensis Nimmo. seed extracts as a potential source of bioactive molecules, antioxidants and enzyme inhibitors

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Abstract

Moringa concanensis Nimmo (Wild Drumstick) is an underutilized edible plant used to treat various diseases. The present study was designed to investigate the phytochemical content and therapeutic potential of M. concanensis seeds using spectroscopic, chromatographic and various in-vitro assays. GC–MS analysis identified 34 compounds with palmitone, palmitic acid, oleic acid, linoleic acid, n-Pentacosane and octacosane as major constituents. Methanolic extract of seeds revealed maximum amount of phytochemicals like phenolics, flavonoids, tannins, flavanols, proanthocyanins and vitamin E. Similarly, methanolic extract showed moderate α-amylase inhibitory effect (72.81 ± 0.46 µg/mL), and ethyl acetate extract revealed notable α-glucosidase inhibitory effect (IC50 of 40.80 ± 0.53 µg/mL). All the studied extracts exhibited decent free radical scavenging ability. Chloroform and ethyl acetate extract of seeds displayed the lowest MIC against the growth of Bacillus subtilis (59.37 µg/mL). The study results support the possible use of M. concanensis seeds towards the preparation of therapeutic and food formulations.

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Funding

The first author is thankful to the Tamilnadu State Council for Science & Technology, Government of Tamil Nadu, Chennai, for granting a Research Fellowship (TNSCST/RFRS/VR/05/2018-19/7626). The authors are grateful to the Science and Engineering Research Board for financial support (Grant No. EMR/2016/007164).

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Authors and Affiliations

  1. Post Graduate and Research Department of Botany, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur, 613 503, India

    Jayaraj Krupa, Peramaiyan Gangapriya, Singamoorthy Amalraj, Moses Sam Arulraj & Muniappan Ayyanar

  2. Centre for Research & Post Graduate Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, 626 123, India

    Ramar Murugan

  3. Department of Pharmacognosy, Goa College of Pharmacy, Panaji, Goa University, Goa, 403 001, India

    Shailendra Gurav

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  1. Jayaraj Krupa
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Correspondence to Muniappan Ayyanar.

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Krupa, J., Murugan, R., Gangapriya, P. et al. Moringa concanensis Nimmo. seed extracts as a potential source of bioactive molecules, antioxidants and enzyme inhibitors. Food Measure 16, 3699–3711 (2022). https://doi.org/10.1007/s11694-022-01463-6

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