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Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion tensor imaging studies

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Abstract

This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls (HC) using the anisotropic effect size–signed differential mapping. A total of 808 patients with PD and 760 HC coming from 27 databases were finally included. Subgroup analyses were conducted considering heterogeneity with respect to medication status, disease stage, analysis methods, and the number of diffusion directions in acquisition. Compared with HC, patients with PD had decreased FA in the left middle cerebellar peduncle, corpus callosum (CC), left inferior fronto-occipital fasciculus, and right inferior longitudinal fasciculus. Most of the main results remained unchanged in subgroup meta-analyses of medicated patients, early stage patients, voxel-based analysis, and acquisition with 30 diffusion directions. The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex. The cerebellum and CC, associated with typical motor impairment, showed the most consistent FA decreases in PD. Medication status, analysis approaches, and the number of diffusion directions have an important impact on the findings, needing careful evaluation in future meta-analyses.

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Acknowledgements

This study was supported by the National Natural Science Foundation (Nos. 81621003, 81761128023, 81220108013, 81227002, and 81030027), the Program for Innovative Research Team in University (No. IRT16R52) of China, the Professorship Award (No. T2014190) of China, and the CMB Distinguished Professorship Award (No. F510000/G16916411) administered by the Institute of International Education.

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Authors and Affiliations

  1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Xueling Suo, Du Lei, Wenbin Li, Lei Li, Song Wang & Qiyong Gong

  2. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA

    Du Lei & Wenbin Li

  3. Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, 610041, China

    Jing Dai

  4. Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Nannan Li, Lan Cheng & Rong Peng

  5. Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L69 3GE, UK

    Graham J. Kemp

  6. Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, 610041, China

    Qiyong Gong

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  1. Xueling Suo
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Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, and Qiyong Gong declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.

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Suo, X., Lei, D., Li, W. et al. Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion tensor imaging studies. Front. Med. 15, 125–138 (2021). https://doi.org/10.1007/s11684-019-0725-5

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