Skip to main content
Log in

Effect of laparoscopic fundoplication treatment on gastroesophageal reflux disease-related respiratory symptoms

  • Clinical Report
  • Published:
Frontiers of Medicine in China Aims and scope Submit manuscript

Abstract

Gastroesophageal reflux disease (GERD) was diagnosed and fundoplication was performed, which relieved the symptoms. This paper explores the effect of fundoplication on GERD-related respiratory symptoms. From January 2007 to October 2008, 64 patients with respiratory symptoms related to GERD were consecutively enrolled for laparoscopic fundoplication. Of these, 60 patients had respiratory symptoms mainly combined with gastroesophageal reflux, while four had respiratory symptoms only. All patients had GERD confirmed, and medical treatment provided before surgery resulted in an insufficiently favorable effect or even producing further complications. All the patients were requested to fill a questionnaire form regarding the severity of symptoms and their medication so as to make an evaluation score for the follow-up. The outcome of respiratory symptoms after surgery was as follows: excellent in 23 cases (35.9%); good in 28 (43.8%); fair in 5 (7.8%); poor in 8 (12.5%). The mean respiratory symptom score decreased from 6.3±2.65 to 2.33±2.37. Laparoscopic fundoplication can be an effective treatment for the majority of patients with GERD-related respiratory symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Lindstrom D R, Wallace J, Loehrl T A, Merati A L, Toohill R J. Nissen fundoplication surgery for extraesophageal manifestations of gastroesophageal reflux (EER). Laryngoscope, 2002, 112(10): 1762–1765

    Article  CAS  PubMed  Google Scholar 

  2. Novitsky Y W, Zawacki J K, Irwin R S, French C T, Hussey V M, Callery M P. Chronic cough due to gastroesophageal reflux disease: efficacy of antireflux surgery. Surg Endosc, 2002, 16(4): 567–571

    Article  CAS  PubMed  Google Scholar 

  3. Hunter J G, Trus T L, Branum G D, Waring J P, Wood W C. A physiologic approach to laparoscopic fundoplication for gastro-esophageal reflux disease. Ann Surg, 1996, 223(6): 673–685

    Article  CAS  PubMed  Google Scholar 

  4. Patti M G, Arcerito M, Feo C V, De Pinto M, Tong J, Gantert W, Tyrrell D, Way L W. An analysis of operations for gastroesophageal reflux disease: identifying the important technical elements. Arch Surg, 1998, 133(6): 600–606

    Article  CAS  PubMed  Google Scholar 

  5. Johnson W E, Hagen J A, DeMeester T R, Kauer W K, Ritter M P, Peters J H, Bremner C G. Outcome of respiratory symptoms after antireflux surgery on patients with gastroesophageal reflux disease. Arch Surg, 1996, 131(5): 489–492

    CAS  PubMed  Google Scholar 

  6. Wang Z G. A belated revelation: From gastroesophageal reflux derived asthma to laryngotracheal spasm. Front Med Chin, 2008, 2(2): 127–129

    Article  Google Scholar 

  7. Triadafilopoulos G. GERD: the potential for endoscopic intervention. Dig Dis, 2004, 22(2): 181–188

    Article  PubMed  Google Scholar 

  8. Richter J E. Extraesophageal presentations of gastroesophageal reflux disease. Semin Gastrointest Dis, 1997, 8(2): 75–89

    CAS  PubMed  Google Scholar 

  9. Crisera C A, Connelly P R, Marmureanu A R, Li M, Rose M I, Longaker MT, Gittes G K. TTF-1 and HNF-3beta in the developing tracheoesophageal fistula: further evidence for the respiratory origin of the distal esophagus. J Pediatr Surg, 1999, 34(9): 1322–1326

    Article  CAS  PubMed  Google Scholar 

  10. Ruth M, Carlsson S, Månsson I, Bengtsson U, Sandberg N. Scintigraphic detection of gastro-pulmonary aspiration in patients with respiratory disorders. Clin Physiol, 1993, 13(1): 19–33

    Article  CAS  PubMed  Google Scholar 

  11. Wang Z G. Not asthma, but GERD: case report. Front Med Chin, 2007, 1(1): 115–119

    Article  CAS  Google Scholar 

  12. Wang Z G, Lai Y G, Wu J M. Evidence from preliminary animal study for gastroesophagolaryngotracheal reflux. Clin Misdiagn Mistherap, 2007, 20(12): 1–2

    Google Scholar 

  13. Lopes F D, Alvarenga G S, Quiles R, Dorna M B, Vieira J E, Dolhnikoff M, Martins M A. Pulmonary responses to tracheal or esophageal acidification in guinea pigs with airway inflammation. J Appl Physiol, 2002, 93(3): 842–847

    PubMed  Google Scholar 

  14. Hamamoto J, Kohrogi H, Kawano O, Iwagoe H, Fujii K, Hirata N, Ando M. Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways in guinea pigs. J Appl Physiol, 1997, 82(3): 738–745

    CAS  PubMed  Google Scholar 

  15. Schan C A, Harding S M, Haile J M, Bradley L A, Richter J E. Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology. Chest, 1994, 106(3): 731–737

    Article  CAS  PubMed  Google Scholar 

  16. Daoui S, D’Agostino B, Gallelli L, Alt X E, Rossi F, Advenier C. Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. Eur Respir J, 2002, 20(2): 268–273

    Article  CAS  PubMed  Google Scholar 

  17. Rosztóczy A, Makk L, Izbéki F, Róka R, Somfay A, Wittmann T. Asthma and gastroesophageal reflux: clinical evaluation of esophago-bronchial reflex and proximal reflux. Digestion, 2008, 77(3–4): 218–224

    Article  PubMed  Google Scholar 

  18. Karoui S, Zouiten L, Matri S, Jomni M T, Boubaker J, Filali A. Nocturnal gastroesophageal reflux disease in asthmatics patients: a pHmetric study about 81 cases. Tunis Med, 2007, 85(12): 1030–1034

    PubMed  Google Scholar 

  19. Tobin R W, Pope C E 2nd, Pellegrini C A, Emond M J, Sillery J, Raghu G. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med, 1998, 158(6): 1804–1808

    CAS  PubMed  Google Scholar 

  20. Wiener G J, Tsukashima R, kelly C, Wolf E, Schmeltzer M, Bankert C, Fisk L, Vaezi M. Oropharyngeal pH monitoring for the detection of liquid and aerosolized supraesophageal gastric reflux. J Voice, 2009, 23(4): 498–504

    Article  PubMed  Google Scholar 

  21. Draaisma W A, Rijnhart-de Jong H G, Broeders I A, Smout A J, Furnee E J, Gooszen H G. Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann Surg, 2006, 244(1): 34–41

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, ZG., Ji, F., Wu, JM. et al. Effect of laparoscopic fundoplication treatment on gastroesophageal reflux disease-related respiratory symptoms. Front. Med. China 4, 254–258 (2010). https://doi.org/10.1007/s11684-010-0029-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11684-010-0029-2

Keywords

Navigation