Abstract
Diffusion tensor imaging quantifies the asymmetry (fractional anisotropy; FA) and amount of water diffusion (mean diffusivity/apparent diffusion coefficient; MD/ADC) and has been used to assess white matter damage following traumatic brain injury (TBI). In healthy brains, diffusion is constrained by the organization of axons, resulting in high FA and low MD/ADC. Following a TBI, diffusion may be altered; however the exact nature of these changes has yet to be determined. A meta-analysis was therefore conducted to determine the location and extent of changes in DTI following adult TBI. The data from 44 studies that compared the FA and/or MD/ADC data from TBI and Control participants in different regions of interest (ROIs) were analyzed. The impact of injury severity, post-injury interval (acute: ≤ 1 week, subacute: 1 week-3 months, chronic: > 3 months), scanner details and acquisition parameters were investigated in subgroup analyses, with the findings indicating that mild TBI should be examined separately to that of moderate to severe injuries. Lower FA values were found in 88% of brain regions following mild TBI and 92% following moderate-severe TBI, compared to Controls. MD/ADC was higher in 95% and 100% of brain regions following mild and moderate-severe TBI, respectively. Moderate to severe TBI resulted in larger changes in FA and MD/ADC than mild TBI. Overall, changes to FA and MD/ADC were widespread, reflecting more symmetric and a higher amount of diffusion, indicative of white matter damage.
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References
Adams, J. H., Doyle, D., Ford, I., Gennarelli, T. A., Graham, D. I., & McLellan, D. R. (1989). Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology, 15(1), 49–59. https://doi.org/10.1111/j.1365-2559.1989.tb03040.x.
Amyot, F., Arciniegas, D. B., Brazaitis, M. P., Curley, K. C., Diaz-Arrastia, R., Gandjbakhche, A.,.. . Stoker, D. (2015). A review of the effectiveness of neuroimaging modalities for the detection of traumatic brain injury. Journal of Neurotrauma, 32(22), 1693–1721. https://doi.org/10.1089/neu.2013.3306.
Aoki, Y., Inokuchi, R., Gunshin, M., Yahagi, N., & Suwa, H. (2012). Diffusion tensor imaging studies of mild traumatic brain injury: A meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 83(9), 870–876. https://doi.org/10.1136/jnnp-2012-302742.
Arfanakis, K., Haughton, V. M., Carew, J. D., Rogers, B. P., Dempsey, R. J., & Meyerand, M. E. (2002). Diffusion tensor MR imaging in diffuse axonal injury. American Journal of Neuroradiology, 23(5), 794–802.
Bandak, F. A., Ling, G., Bandak, A., & De Lanerolle, N. C. (2015). Injury biomechanics, neuropathology, and simplified physics of explosive blast and impact mild traumatic brain injury. Handbook of Clinical Neurology, 127, 89–104. https://doi.org/10.1016/b978-0-444-52892-6.00006-4.
Bazarian, J. J., Zhong, J., Blyth, B., Zhu, T., Kavcic, V., & Peterson, D. (2007). Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study. Journal of Neurotrauma, 24(9), 1447–1459. https://doi.org/10.1089/neu.2007.0241. *1
Bigler, E. D., & Bazarian, J. J. (2010). Diffusion tensor imaging: a biomarker for mild traumatic brain injury? Neurology, 74(8), 626–627. https://doi.org/10.1212/WNL.0b013e3181d3e43a.
Blyth, B. J., & Bazarian, J. J. (2010). Traumatic alterations in consciousness: traumatic brain injury. Emergency Medicine Clinics of North America, 28(3), 571–594. https://doi.org/10.1016/j.emc.2010.03.003.
Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2010). A basic introduction to fixed-effect and random-effects models for meta-analysis. Research Synthesis Methods, 1(2), 97–111. https://doi.org/10.1002/jrsm.12.
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Subgroup Analyses Introduction to Meta-Analysis (pp. 149–186): John Wiley & Sons, Ltd.
Boyles, A. L., Harris, S. F., Rooney, A. A., & Thayer, K. A. (2011). Forest plot viewer: a new graphing tool. Epidemiology, 22(5), 746–747. https://doi.org/10.1097/EDE.0b013e318225ba48.
Brandstack, N., Kurki, T., Hiekkanen, H., & Tenovuo, O. (2011). Diffusivity of normal-appearing tissue in acute traumatic brain injury. Clinical Neuroradiology, 21(2), 75–82. https://doi.org/10.1007/s00062-011-0058-5. *2
Brazinova, A., Rehorcikova, V., Taylor, M. S., Buckova, V., Majdan, M., Psota, M.,.. . Synnot, A. (2015). Epidemiology of traumatic brain injury in Europe: a living systematic review. Journal of Neurotrauma. https://doi.org/10.1089/neu.2015.4126.
Chang, M. C., & Jang, S. H. (2010). Corpus callosum injury in patients with diffuse axonal injury: a diffusion tensor imaging study. NeuroRehabilitation, 26(4), 339–345. https://doi.org/10.3233/NRE-2010-0571.
Chang, M. C., Kim, S. H., Kim, O. L., Bai, D. S., & Jang, S. H. (2010). The relation between fornix injury and memory impairment in patients with diffuse axonal injury: a diffusion tensor imaging study. NeuroRehabilitation, 26(4), 347–353. https://doi.org/10.3233/NRE-2010-0572.
Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155–159.
Cristofori, I., & Levin, H. S. (2015). Traumatic brain injury and cognition. Handbook of Clinical Neurology, 128, 579–611. https://doi.org/10.1016/B978-0-444-63521-1.00037-6.
D’Souza, M. M., Trivedi, R., Singh, K., Grover, H., Choudhury, A., Kaur, P.,.. . Tripathi, R. P. (2015). Traumatic brain injury and the post-concussion syndrome: a diffusion tensor tractography study. Indian Journal of Radiology and Imaging, 25(4), 404–414. https://doi.org/10.4103/0971-3026.169445. *3
Dean, P. J. A., Sato, J. R., Vieira, G., McNamara, A., & Sterr, A. (2015). Multimodal imaging of mild traumatic brain injury and persistent postconcussion syndrome. Brain and Behavior, 5(1), 45–61. https://doi.org/10.1002/brb3.292. *4
Dodd, A. B., Epstein, K., Ling, J. M., & Mayer, A. R. (2014). Diffusion tensor imaging findings in semi-acute mild traumatic brain injury. Journal of Neurotrauma, 31(14), 1235–1248. https://doi.org/10.1089/neu.2014.3337.
Douglas, D. B., Iv, M., Douglas, P. K., Anderson, A., Vos, S. B., Bammer, R.,.. . Wintermark, M. (2015). Diffusion tensor imaging of TBI: Potentials and challenges. Topics in Magnetic Resonance Imaging, 24(5), 241–251. https://doi.org/10.1097/rmr.0000000000000062.
Ellis, P. D. (2010). The Essential Guide to Effect Sizes: Statistical Power, Meta-Analysis, and the Interpretation of Research Results. United Kingdom: University Press, Cambridge.
Fitsiori, A., Nguyen, D., Karentzos, A., Delavelle, J., & Vargas, M. I. (2011). The corpus callosum: white matter or terra incognita. British Journal of Radiology, 84(997), 5–18. https://doi.org/10.1259/bjr/21946513.
FitzGerald, D. B., & Crosson, B. A. (2011). Diffusion weighted imaging and neuropsychological correlates in adults with mild traumatic brain injury. International Journal of Psychophysiology, 82(1), 79–85. https://doi.org/10.1016/j.ijpsycho.2011.02.011.
Gardner, A., Kay-Lambkin, F., Stanwell, P., Donnelly, J., Williams, W. H., Hiles, A.,.. . Jones, D. K. (2012). A systematic review of diffusion tensor imaging findings in sports-related concussion. Journal of Neurotrauma, 29(16), 2521–2538. https://doi.org/10.1089/neu.2012.2628.
Grossman, E. J., Ge, Y. L., Jensen, J. H., Babb, J. S., Miles, L., Reaume, J.,.. . Inglese, M. (2012). Thalamus and cognitive impairment in mild traumatic brain injury: a diffusional kurtosis imaging study. Journal of Neurotrauma, 29(13), 2318–2327. https://doi.org/10.1089/neu.2011.1763. *5
Haberg, A. K., Olsen, A., Moen, K. G., Schirmer-Mikalsen, K., Visser, E., Finnanger, T. G.,.. . Eikenes, L. (2015). White matter microstructure in chronic moderate-to-severe traumatic brain injury: impact of acute-phase injury-related variables and associations with outcome measures. Journal of Neuroscience Research, 93(7), 1109–1126. https://doi.org/10.1002/jnr.23534.
Hasan, K. M., Wilde, E. A., Miller, E. R., Kumar Patel, V., Staewen, T. D., Frisby, M. L.,.. . Narayana, P. A. (2014). Serial atlas-based diffusion tensor imaging study of uncomplicated mild traumatic brain injury in adults. Journal of Neurotrauma, 31(5), 466–475. https://doi.org/10.1089/neu.2013.3085.
Hedges, L. V., & Olkin, I. (1985). Statistical methods for meta-analysis. London: Academic Press Inc. Ltd.
Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. Bmj, 327(7414), 557–560. https://doi.org/10.1136/bmj.327.7414.557.
Hong, J. H., Jang, S. H., Kim, O. L., Kim, S. H., Ahn, S. H., Byun, W. M.,.. . Lee, D. H. (2012). Neuronal loss in the medial cholinergic pathway from the nucleus basalis of Meynert in patients with traumatic axonal injury: a preliminary diffusion tensor imaging study. Journal of Head Trauma Rehabilitation, 27(3), 172–176. https://doi.org/10.1097/HTR.0b013e318217192d. *6
Huedo-Medina, T. B., Sánchez-Meca, J., Marín-Martínez, F., & Botella, J. (2006). Assessing heterogeneity in meta-analysis: Q statistic or I2 Index? Psychological Methods, 11(2), 193–206. https://doi.org/10.1037/1082-989X.11.2.193.
Huisman, T. A. (2010). Diffusion-weighted and diffusion tensor imaging of the brain, made easy. Cancer Imaging, 10, 163–171. https://doi.org/10.1102/1470-7330.2010.9023.
Huisman, T. A., Schwamm, L. H., Schaefer, P. W., Koroshetz, W. J., Shetty-Alva, N., Ozsunar, Y.,.. . Sorensen, A. G. (2004). Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. American Journal of Neuroradiology, 25(3), 370–376.
Hulkower, M. B., Poliak, D. B., Rosenbaum, S. B., Zimmerman, M. E., & Lipton, M. L. (2013). A decade of DTI in traumatic brain injury: 10 years and 100 articles later. American Journal of Neuroradiology, 34(11), 2064–2074. https://doi.org/10.3174/ajnr.A3395.
Ilvesmaki, T., Luoto, T. M., Hakulinen, U., Brander, A., Ryymin, P., Eskola, H.,.. . Ohman, J. (2014). Acute mild traumatic brain injury is not associated with white matter change on diffusion tensor imaging. Brain: A Journal of Neurology, 137(7), 1876–1882. https://doi.org/10.1093/brain/awu095.*7
Imperati, D., Colcombe, S., Kelly, C., Martino, A., Zhou, J., Castellanos, F. X., & Milham, M. P. (2011). Differential development of human brain white matter tracts. PLoS One, 6(8). https://doi.org/10.1371/journal.pone.0023437.
Inglese, M., Makani, S., Johnson, G., Cohen, B. A., Silver, J. A., Gonen, O., & Grossman, R. I. (2005). Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study. Journal of Neurosurgery, 103(2), 298–303. https://doi.org/10.3171/jns.2005.103.2.0298. *8
Jang, S. H., Kim, S. H., Kim, O. R., Byun, W. M., Kim, M. S., Seo, J. P., & Chang, M. C. (2013). Cingulum injury in patients with diffuse axonal injury: a diffusion tensor imaging study. Neuroscience Letters, 543, 47–51. https://doi.org/10.1016/j.neulet.2013.02.058.*9
Johnson, S. B., Blum, R. W., & Giedd, J. N. (2009). Adolescent maturity and the brain: the promise and pitfalls of neuroscience research in adolescent health policy. Journal of Adolescent Health, 45(3), 216–221. https://doi.org/10.1016/j.jadohealth.2009.05.016.
Kasahara, K., Hashimoto, K., Abo, M., & Senoo, A. (2012). Voxel- and atlas-based analysis of diffusion tensor imaging may reveal focal axonal injuries in mild traumatic brain injury - comparison with diffuse axonal injury. Magnetic Resonance Imaging, 30(4), 496–505. https://doi.org/10.1016/j.mri.2011.12.018. *10
Kennedy, M. R., Wozniak, J. R., Muetzel, R. L., Mueller, B. A., Chiou, H. H., Pantekoek, K., & Lim, K. O. (2009). White matter and neurocognitive changes in adults with chronic traumatic brain injury. Journal of the International Neuropsychological Society, 15(1), 130–136. https://doi.org/10.1017/s1355617708090024.*11
Kim, J. H., Ahn, S. H., Cho, Y. W., Kim, S. H., & Jang, S. H. (2015). The relation between injury of the spinothalamocortical tract and central pain in chronic patients with mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 30(6), 40–46. https://doi.org/10.1097/htr.0000000000000121.*12
Kraus, M. F., Susmaras, T., Caughlin, B. P., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007). White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain: A Journal of Neurology, 130(10), 2508–2519. http://dx.doi.org.proxy.library.adelaide.edu.au/10.1093/brain/awm216.*13
Kumar, R., Gupta, R. K., Husain, M., Chaudhry, C., Srivastava, A., Saksena, S., & Rathore, R. K. S. (2009). Comparative evaluation of corpus callosum DTI metrics in acute mild and moderate traumatic brain injury: Its correlation with neuropsychometric test. Brain Injury, 23(7–8), 675–685. https://doi.org/10.1080/02699050903014915. *14
Kumar, R., Husain, M., Gupta, R. K., Hasan, K. M., Haris, M., Agarwal, A. K.,.. . Narayana, P. A. (2009). Serial changes in the white matter diffusion tensor imaging metrics in moderate traumatic brain injury and correlation with neuro-cognitive function. Journal of Neurotrauma, 26(4), 481–495. https://doi.org/10.1089/neu.2008.0461.
Kumar, R., Saksena, S., Husain, M., Srivastava, A., Rathore, R. K. S., Agarwal, S., & Gupta, R. K. (2010). Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests: a 2-year follow-up study. Journal of Head Trauma Rehabilitation, 25(1), 31–42.
Lakens, D. (2013). Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Frontiers in Psychology, 4, 863. https://doi.org/10.3389/fpsyg.2013.00863.
Lange, R. T., Iverson, G. L., Brubacher, J. R., Madler, B., & Heran, M. K. (2012). Diffusion tensor imaging findings are not strongly associated with postconcussional disorder 2 months following mild traumatic brain injury. The Journal of Head Trauma Rehabilitation, 27(3), 188–198. https://doi.org/10.1097/HTR.0b013e318217f0ad. *15
Lange, R. T., Panenka, W. J., Shewchuk, J. R., Heran, M. K., Brubacher, J. R., Bioux, S.,.. . Iverson, G. L. (2015). Diffusion tensor imaging findings and postconcussion symptom reporting six weeks following mild traumatic brain injury. Archives of Clinical Neuropsychology, 30(1), 7–25. https://doi.org/10.1093/arclin/acu060.
Lee, H. D., & Jang, S. H. (2015). Injury of the corticoreticular pathway in patients with mild traumatic brain injury: a diffusion tensor tractography study. Brain Injury, 29(10), 1219–1222. https://doi.org/10.3109/02699052.2015.1045028. *16
Ling, J. M., Pena, A., Yeo, R. A., Merideth, F. L., Klimaj, S., Gasparovic, C., & Mayer, A. R. (2012). Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: a longitudinal perspective. Brain: A Journal of Neurology, 135(4), 1281–1292. http://dx.doi.org.proxy.library.adelaide.edu.au/10.1093/brain/aws073. *17
Lipsey, M. W., & Wilson, D. B. (2001). Practical meta-analysis. Thousand Oaks, CA: Sage Publications.
Lipton, M. L., Gellella, E., Lo, C., Gold, T., Ardekani, B. A., Shifteh, K.,.. . Branch, C. A. (2008). Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: a voxel-wise analysis of diffusion tensor imaging. Journal of Neurotrauma, 25(11), 1335–1342. https://doi.org/10.1089/neu.2008.0547. *18
Little, D. M., Kraus, M. F., Joseph, J., Geary, E. K., Susmaras, T., Zhou, X. J.,.. . Gorelick, P. B. (2010). Thalamic integrity underlies executive dysfunction in traumatic brain injury. Neurology, 74(7), 558–564. https://doi.org/10.1212/WNL.0b013e3181cff5d5. *19
Lo, C., Shifteh, K., Gold, T., Bello, J. A., & Lipton, M. L. (2009). Diffusion tensor imaging abnormalities in patients with mild traumatic brain injury and neurocognitive impairment. Journal of Computer Assisted Tomography, 33(2), 293–297. https://doi.org/10.1097/RCT.0b013e31817579d1. *20
Madden, D. J., Bennett, I. J., Burzynska, A., Potter, G. G., Chen, N. K., & Song, A. W. (2012). Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochimica et Biophysica Acta – Molecular Basis of Disease, 1822(3), 386–400. https://doi.org/10.1016/j.bbadis.2011.08.003.
Maruta, J., Palacios, E. M., Zimmerman, R. D., Ghajar, J., & Mukherjee, P. (2016). Chronic post-concussion neurocognitive deficits. I. Relationship with white matter integrity. Frontiers in Human Neuroscience, 10, 35. https://doi.org/10.3389/fnhum.2016.00035. *22
Maruta, J., Suh, M., Niogi, S. N., Mukherjee, P., & Ghajar, J. (2010). Visual tracking synchronization as a metric for concussion screening. The Journal of Head Trauma Rehabilitation, 25(4), 293–305. *21
Matsushita, M., Hosoda, K., Naitoh, Y., Yamashita, H., & Kohmura, E. (2011). Utility of diffusion tensor imaging in the acute stage of mild to moderate traumatic brain injury for detecting white matter lesions and predicting long-term cognitive function in adults. Journal of Neurosurgery, 115(1), 130–139. https://doi.org/10.3171/2011.2.jns101547. *23
Mayer, A. R., Ling, J., Mannell, M. V., Gasparovic, C., Phillips, J. P., Doezema, D.,.. . Yeo, R. A. (2010). A prospective diffusion tensor imaging study in mild traumatic brain injury. Neurology, 74(8), 643–650. https://doi.org/10.1212/WNL.0b013e3181d0ccdd.
McKee, A. C., & Daneshvar, D. H. (2015). The neuropathology of traumatic brain injury. Handbook of Clinical Neurology, 127, 45–66. https://doi.org/10.1016/B978-0-444-52892-6.00004-0.
Messe, A., Caplain, S., Paradot, G., Garrigue, D., Mineo, J. F., Ares, S., Lehericy, G. S. (2010). Diffusion tensor imaging and white matter lesions at the subacute stage in mild traumatic brain injury with persistent neurobehavioral impairment. Human Brain Mapping, 32(6), 999–1011. https://doi.org/10.1002/hbm.21092. *24
Messe, A., Caplain, S., Pelegrini-Issac, M., Blancho, S., Montreuil, M., Levy, R.,.. . Benali, H. (2012). Structural integrity and postconcussion syndrome in mild traumatic brain injury patients. Brain Imaging and Behavior, 6(2), 283–292. https://doi.org/10.1007/s11682-012-9159-2. *25
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6(7), e1000097. https://doi.org/10.1371/journal.pmed.1000097.
Mueller, B. A., Lim, K. O., Hemmy, L., & Camchong, J. (2015). Diffusion MRI and its role in neuropsychology. Neuropsychology Review, 25(3), 250–271. https://doi.org/10.1007/s11065-015-9291-z.
Narayana, P. A., Yu, X., Hasan, K. M., Wilde, E. A., Levin, H. S., Hunter, J. V.,.. . McCarthy, J. J. (2015). Multi-modal MRI of mild traumatic brain injury. NeuroImage: Clinical, 7, 87–97. https://doi.org/10.1016/j.nicl.2014.07.010.
Niogi, S. N., & Mukherjee, P. (2010). Diffusion tensor imaging of mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 25(4), 241–255. https://doi.org/10.1097/HTR.0b013e3181e52c2a.
Orwin, R. G. (1983). A fail-safe N for effect size in meta-analysis. Journal of Educational Statistics, 8(2), 157–159.
Palacios, E. M., Fernandez-Espejo, D., Junque, C., Sanchez-Carrion, R., Roig, T., Tormos, J. M.,.. . Vendrell, P. (2011). Diffusion tensor imaging differences relate to memory deficits in diffuse traumatic brain injury. BMC Neurology, 11(24). https://doi.org/10.1186/1471-2377-11-24. *26
Palacios, E. M., Sala-Llonch, R., Junque, C., Fernandez-Espejo, D., Roig, T., Tormos, J. M.,.. . Vendrell, P. (2013). Long-term declarative memory deficits in diffuse TBI: correlations with cortical thickness, white matter integrity and hippocampal volume. Cortex, 49(3), 646–657. https://doi.org/10.1016/j.cortex.2012.02.011. *27
Palmer, H. S., Garzon, B., Xu, J., Berntsen, E. M., Skandsen, T., & Haberg, A. K. (2010). Reduced fractional anisotropy does not change the shape of the hemodynamic response in survivors of severe traumatic brain injury. Journal of Neurotrauma, 27(5), 853–862. https://doi.org/10.1089/neu.2009.1225. *28
Pandit, A., Expert, P., Lambiotte, R., Bonnelle, V., Leech, R., Turkheimer, F., & Sharp, D. (2013). Traumatic brain injury impairs small world topology. Neurology, 80(20), 1826–1833. https://doi.org/10.1212/WNL.0b013e3182929f38.
Pinto, P. S., Poretti, A., Meoded, A., Tekes, A., & Huisman, T. A. (2012). The unique features of traumatic brain injury in children. Review of the characteristics of the pediatric skull and brain, mechanisms of trauma, patterns of injury, complications and their imaging findings – part 1. Journal of Neuroimaging, 22(2), e1–e17. https://doi.org/10.1111/j.1552-6569.2011.00688.x.
Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M.,.. . Sharp, D. J. (2011). Inflammation after trauma: Microglial activation and traumatic brain injury. Annals of Neurology, 70(3), 374–383. https://doi.org/10.1002/ana.22455.
Roberts, R. M., Mathias, J. L., & Rose, S. E. (2014). Diffusion tensor imaging (DTI) findings following pediatric non-penetrating TBI: a meta-analysis. Developmental Neuropsychology, 39(8), 600–637. https://doi.org/10.1080/87565641.2014.973958.
Rosenthal, J. A. (1996). Qualitative descriptors of strength of association and effect size. Journal of Social Service Research, 21(4), 37–59.
Rothstein, H. R., Sutton, A. J., & Borenstein, M. (2006). Publication bias in meta-analysis: Prevention, assessment and adjustments: John Wiley & Sons.
Rutgers, D. R., Fillard, P., Paradot, G., Tadie, M., Lasjaunias, P., & Ducreux, D. (2008). Diffusion tensor imaging characteristics of the corpus callosum in mild, moderate, and severe traumatic brain injury. American Journal of Neuroradiology, 29(9), 1730–1735. https://doi.org/10.3174/ajnr.A1213. *29
Santiago, L. A., Oh, B. C., Dash, P. K., Holcomb, J. B., & Wade, C. E. (2012). A clinical comparison of penetrating and blunt traumatic brain injuries. Brain Injury, 26(2), 107–125. https://doi.org/10.3109/02699052.2011.635363.
Scott, G., Hellyer, P. J., Ramlackhansingh, A. F., Brooks, D. J., Matthews, P. M., & Sharp, D. J. (2015). Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage. Journal of Neuroinflammation, 12, 224. https://doi.org/10.1186/s12974-015-0445-y. *30
Seo, J. P., Kim, O. L., Kim, S. H., Chang, M. C., Kim, M. S., Son, S. M., & Jang, S. H. (2012). Neural injury of uncinate fasciculus in patients with diffuse axonal injury. NeuroRehabilitation, 30(4), 323–328. https://doi.org/10.3233/nre-2012-0762. *31
Shenton, M. E., Hamoda, H. M., Schneiderman, J. S., Bouix, S., Pasternak, O., Rathi, Y.,.. . Zafonte, R. (2012). A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging and Behavior, 6(2), 137–192. https://doi.org/10.1007/s11682-012-9156-5.
Shiramizu, H., Masuko, A., Ishizaka, H., Shibata, M., Atsumi, H., Imai, M.,.. . Matsumae, M. (2008). Mechanism of injury to the corpus callosum, with particular reference to the anatomical relationship between site of injury and adjacent brain structures. Neurologia Medico-chirurgica, 48(1), 1–6. https://doi.org/10.2176/nmc.48.1.
Sidaros, A., Engberg, A. W., Sidaros, K., Liptrot, M. G., Herning, M., Petersen, P.,.. . Rostrup, E. (2008). Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: A longitudinal study. Brain: A Journal of Neurology, 131(2), 559–572. http://dx.doi.org.proxy.library.adelaide.edu.au/10.1093/brain/awm294. *32
Smits, M., Houston, G. C., Dippel, D. W., Wielopolski, P. A., Vernooij, M. W., Koudstaal, P. J.,.. . van der Lugt, A. (2011). Microstructural brain injury in post-concussion syndrome after minor head injury. Neuroradiology, 53(8), 553–563. https://doi.org/10.1007/s00234-010-0774-6. *33
Strauss, S., Hulkower, M., Gulko, E., Zampolin, R. L., Gutman, D., Chitkara, M.,.. . Lipton, M. L. (2015). Current clinical applications and future potential of diffusion tensor imaging in traumatic brain injury. Topics in Magnetic Resonance Imaging, 24(6), 353–362. https://doi.org/10.1097/RMR.0000000000000071.
Tollard, E., Galanaud, D., Perlbarg, V., Sanchez-Pena, P., Le Fur, Y., Abdennour, L.,.. . Puybasset, L. (2009). Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: preliminary results. Critical Care Medicine, 37(4), 1448–1455. https://doi.org/10.1097/CCM.0b013e31819cf050. *34
Ubukata, S., Ueda, K., Sugihara, G., Yassin, W., Aso, T., Fukuyama, H., & Murai, T. (2015). Corpus callosum pathology as a potential surrogate marker of cognitive impairment in diffuse axonal injury. The Journal of Neuropsychiatry & Clinical Neuroscience. https://doi.org/10.1176/appi.neuropsych.15070159. *35
Uchino, A., Takase, Y., Nomiyama, K., Egashira, R., & Kudo, S. (2006). Acquired lesions of the corpus callosum: MR imaging. European Radiology, 16(4), 905–914. https://doi.org/10.1007/s00330-005-0037-9.
Veeramuthu, V., Narayanan, V., Kuo, T. L., Delano-Wood, L., Chinna, K., Bondi, M. W.,.. . Ramli, N. (2015). Diffusion tensor imaging parameters in mild traumatic brain injury and Its correlation with early neuropsychological impairment: a longitudinal study. Journal of Neurotrauma, 32(19), 1497–1509. https://doi.org/10.1089/neu.2014.3750. *36
Wada, T., Asano, Y., & Shinoda, J. (2012). Decreased fractional anisotropy evaluated using tract-based spatial statistics and correlated with cognitive dysfunction in patients with mild traumatic brain injury in the chronic stage. American Journal Neuroradiology, 33(11), 2117–2122. https://doi.org/10.3174/ajnr.A3141. *37
Waljas, M., Lange, R. T., Hakulinen, U., Huhtala, H., Dastidar, P., Hartikainen, K.,.. . Iverson, G. L. (2014). Biopsychosocial outcome after uncomplicated mild traumatic brain injury. Journal of Neurotrauma, 31(1), 108–124. https://doi.org/10.1089/neu.2013.2941. *38
Wilde, E. A., Li, X., Hunter, J. V. M., Narayana, P. A., Hasan, K. M., Biekman, B.,.. . Levin, H. S. (2016). Loss of consciousness is related to white matter injury in mild traumatic brain injury. Journal of Neurotrauma, 33(22), 2000–2010. https://doi.org/10.1089/neu.2015.4212. *39
Xu, J., Rasmussen, I. A., Lagopoulos, J., & Haberg, A. (2007). Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging. Journal of Neurotrauma, 24(5), 753–765. https://doi.org/10.1089/neu.2006.0208. *40
Yao, S., Song, J., Gao, L., Yan, Y., Huang, C., Ding, H.,.. . Xu, G. (2015). Thalamocortical sensorimotor circuit damage associated with disorders of consciousness for diffuse axonal injury patients. Journal of the Neurological Sciences, 356(1–2), 168–174. https://doi.org/10.1016/j.jns.2015.06.044. *41
Yuh, E. L., Cooper, S. R., Mukherjee, P., Yue, J. K., Lingsma, H. F., Gordon, W. A.,.. . Track-Tbi, I. (2014). Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: A TRACK-TBI study. Journal of Neurotrauma, 31(17), 1457–1477. https://doi.org/10.1089/neu.2013.3171. *42
Zhang, K., Johnson, B., Pennell, D., Ray, W., Sebastianelli, W., & Slobounov, S. (2010). Are functional deficits in concussed individuals consistent with white matter structural alterations: combined FMRI & DTI study. Experimental Brain Research, 204(1), 57–70. https://doi.org/10.1007/s00221-010-2294-3. *43
Zhu, Y., Li, Z., Bai, L., Tao, Y., Sun, C., Li, M.,.. . Zhang, M. (2014). Loss of microstructural integrity in the limbic-subcortical networks for acute symptomatic traumatic brain injury. Biomed Research International. https://doi.org/10.1155/2014/548392. *44
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Wallace, E.J., Mathias, J.L. & Ward, L. Diffusion tensor imaging changes following mild, moderate and severe adult traumatic brain injury: a meta-analysis. Brain Imaging and Behavior 12, 1607–1621 (2018). https://doi.org/10.1007/s11682-018-9823-2
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DOI: https://doi.org/10.1007/s11682-018-9823-2