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Cytocompatibility Evaluation of Ti-6Al-4V Alloy After Gas Oxynitriding

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Abstract

The oxynitriding of Ti-6Al-4V alloy was realized by thermodiffusion saturation of non-stoichiometric titanium nitride by oxygen (P(O2) = 10−3 to 1 Pa). The oxygen content in TiNxO1−x increased by increasing P(O2) and it led to transformation into TiO2 as follows: TiN0.46O0.54 → TiN0.42O0.58 → TiN0.36O0.64 + TiO2. It caused an increase in the viability of pseudonormal human cells of HEK293T line after 8 days of testing. TiN0.36O0.64 + TiO2 coating exhibited normal morphology and provided 1.2-fold higher cytocompatibility compared to Ti-6Al-4V alloy. This coating can be recommended for further in-depth testing as bio-implant material.

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Authors and Affiliations

  1. Karpenko Physico-Mechanical Institute of National Academy of Sciences of Ukraine, 5, Naukova Str., Lviv, 79060, Ukraine

    I. M. Pohrelyuk, O. V. Tkachuk & R. V. Proskurnyak

  2. Institute of Cell Biology of National Academy of Sciences of Ukraine, 14/16, Dragomanov Str., Lviv, 79005, Ukraine

    N. M. Boiko, O. Yu. Kluchivska & R. S. Stoika

  3. Institute of Metallurgy and Materials Science of Polish Academy of Sciences, 25, W. Reymonta Str., 30-059, Kraków, Poland

    P. Ozga

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  1. I. M. Pohrelyuk
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Pohrelyuk, I.M., Tkachuk, O.V., Proskurnyak, R.V. et al. Cytocompatibility Evaluation of Ti-6Al-4V Alloy After Gas Oxynitriding. J. of Materi Eng and Perform 29, 7785–7792 (2020). https://doi.org/10.1007/s11665-020-05265-z

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  • DOI: https://doi.org/10.1007/s11665-020-05265-z

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