Abstract
Objective
To assess the antinociceptive and anti-inflammatory properties of the aqueous extract of Armadillidium vulgare (AV).
Methods
The antinociceptive effect of AV (400, 600 and 800 mg/kg) was investigated in mice using the acetic acid-induced writhing, formalin-induced nociceptive, and hot plate tests. Phlogogen-induced paw edema using carrageenan, dextran, or compound 48/80 as phlogogen was used as inflammatory models to evaluate AV's anti-inflammatory effect. Additionally, the bioactive substances glucosamine (GLcN) and taurine in AV were determined using high-performance liquid chromatography.
Results
Oral treatment of the mice with AV (600 and 800 mg/kg) significantly reduced the number of writhes in the acetic acid-induced writhing test (P<0.01) but not the hot plate test (P>0.05). All doses tested significantly inhibited paw-withdrawal during the second phase of the formalin-induced nociceptive model (P<0.01). AV demonstrated a strong anti-inflammatory effect in all those inflammatory models (P<0.05).
Conclusions
AV has antinociceptive and anti-inflammatory effects, providing scientific evidence of the efficacy of its traditional use in pain treatment. Furthermore, GLcN and taurine contribute, at least in part, to the anti-inflammatory activity of AV.
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Acknowledgments
The authors are grateful to Prof. LIU Chuan-ming (School of Traditional Chinese Medicine, Southern Medical University) for his support in the identification of the medicinal animals and Prof. HUANG Yong, Prof. TONG Li (School of Traditional Chinese Medicine, Southern Medical University), and Dr. LI Xiao-long (Dalian Institute of Chemical Physics, Chinese Academy of Sciences) for imparting their valuable knowledge and technical assistance.
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Guo, Ss., Ren, My., Song, S. et al. Evaluation of antinociceptive and anti-inflammatory effects of aqueous extract of Armadillidium vulgare Latreille. Chin. J. Integr. Med. 23, 138–145 (2017). https://doi.org/10.1007/s11655-016-2646-3
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DOI: https://doi.org/10.1007/s11655-016-2646-3