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Scutellaria baicalensis in stroke management: Nature’s blessing in traditional Eastern medicine

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Abstract

Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastern medicine, especially in Chinese medicine. The major phytochemicals isolated from S. baicalensis are flavonoids, glycosides and their glucoronides such as baicalin, baicalein, wogonin etc. More than 30 different kinds of flavonoids are isolated from this plant. S. baicalensis and its flavonoids are reported to have several pharmacological activities, which includes anti-allergic, antioxidant, anti apoptic, anti-inflammatory effects and many more. Recently, S. baicalensis and its isolated flavonoids have been studied for their neuroprotective effects, through a variety of in vitro and in vivo models of neurodegenerative diseases, plausibly suggesting that S. baicalensis has salutary effect as a nature’s blessing for neuroprotection. In this review, we are focousing on the neuroprotective effects of S. baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death. We aimed at compiling all the information regarding the neuroprotective effect of S. baicalensis in various experimental models of cerebral ischemia or stroke.

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References

  1. Kim H. Neuroprotective herbs for stroke therapy in traditional Eastern medicine. Neurol Res 2005;27:287–301.

    Article  PubMed  Google Scholar 

  2. Wu CJ, Chen JT, Yen TL, Jayakumar T, Chou DS, Hsiao G, et al. Neuroprotection by the traditional Chinese medicine, Tao-Hong-Si-Wu-Tang, against middle cerebral artery occlusion-induced cerebral ischemia in rats. Evid Based Complement Alternat Med 2011;2011:803015.

    PubMed Central  PubMed  Google Scholar 

  3. Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Phytomedicine 2002;9:478–484.

    Article  CAS  PubMed  Google Scholar 

  4. Willis JC, Shaw HKA, eds. A dictionary of the flowering plants and ferns. 7th ed. Cambridge: Cambridge U.P. 1966.

    Google Scholar 

  5. Bruno M, Piozzi, F, Maggio, AM, Simmonds MSJ. Antifeedant activity of neoclerodane diterpenoids from two Sicilian species of Scutellaria. Biochem System Ecology 2002;30:793–799.

    Article  CAS  Google Scholar 

  6. Brekhman II, Grinevitch MA, Kyu KB. Oriental medicine: a computerized study of complex recipes and their components: herbs most frequently used in traditional Japanese and Korean medicine. Am J Chin Med 1981;9:134–143.

    Article  CAS  PubMed  Google Scholar 

  7. Li HB, Jiang Y, Chen F. Separation methods used for Scutellaria baicalensis active components. J Chromatogr B Analyt Technol Biomed Life Sci 2004;812:277–290.

    Article  CAS  PubMed  Google Scholar 

  8. Horvath CR, Martos PA, Saxena PK. Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A 2005;1062:199–207.

    Article  CAS  PubMed  Google Scholar 

  9. Chen SL, Gilbert MG, Li XW, eds. Flora of China. Missouri Botanical Garden Press; 1994 (Volume 17):93.

  10. Yang SZ. The Divine Farmer’s Materia Medica: A Translation of the Shen Nong Ben Cao. Boulder: Blue Poppy Press; 1998.

    Google Scholar 

  11. Han J, Ye M, Xu M, Sun J, Wang B, Guo D. Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007;848:355–362.

    Article  CAS  PubMed  Google Scholar 

  12. Kazutaka Nishikawa KI. Flavonoids in root cultures of Scutellaria baicalensis. J Plant Physiol 1997;151:633–636.

    Article  Google Scholar 

  13. Shang X, He X, Li M, Zhang R, Fan P, Zhang Q, Jia Z. The genus Scutellaria: an ethnopharmacological and phytochemical review. J Ethnopharmacol 2010;128:279–313.

    Article  CAS  PubMed  Google Scholar 

  14. Koda A, Watanabe S, Yanagihara Y, Nagai H, Sakamoto K. A comparative study of the anti-allergic effects of disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG). Jpn J Pharmacol 1977;27:31–38.

    Article  CAS  PubMed  Google Scholar 

  15. Li BQ, Fu T, Gong WH, Dunlop N, Kung H, Yan Y, et al. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 2000;49:295–306.

    Article  CAS  PubMed  Google Scholar 

  16. Li BQ, Fu T, Yan YD, Baylor NW, Ruscetti FW, Kung HF. Inhibition of HIV infection by baicalin—a flavonoid compound purified from Chinese herbal medicine. Cell Mol Biol Res 1993;39:119–124.

    CAS  PubMed  Google Scholar 

  17. Konoshima T, Kokumai M, Kozuka M, Iinuma M, Mizuno M, Tanaka T, et al. Studies on inhibitors of skin tumor promotion. XI. Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their anti-tumor-promoting activities. Chem Pharm Bull (Tokyo) 1992;40:531–533.

    Article  CAS  Google Scholar 

  18. Ikemoto S, Sugimura K, Yoshida N, Yasumoto R, Wada S, Yamamoto K, et al. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 2000;55:951–955.

    Article  CAS  PubMed  Google Scholar 

  19. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1999;1472:643–650.

    Article  CAS  PubMed  Google Scholar 

  20. Kimura Y, Yokoi K, Matsushita N, Okuda H. Effects of flavonoids isolated from Scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. J Pharm Pharmacol 1997;49:816–822.

    Article  CAS  PubMed  Google Scholar 

  21. Jung SH, Kang KD, Ji D, Fawcett RJ, Safa R, Kamalden TA, et al. The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. Neurochem Int 2008;53:325–337.

    Article  CAS  PubMed  Google Scholar 

  22. Zhang XP, Li ZF, Liu XG. Review in pharmacological study of baicalein. Chin Pharmacol Bull 2001;17:711–713.

    CAS  Google Scholar 

  23. Shimizu I. Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. J Gastroenterol Hepatol 2000;15(Suppl):D84–D90.

    Article  PubMed  Google Scholar 

  24. Nan JX, Park EJ, Kim YC, Ko G, Sohn DH. Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats. J Pharm Pharmacol 2002;54:555–563.

    Article  CAS  PubMed  Google Scholar 

  25. Kim JY, Lee S, Kim DH, Kim BR, Park R, Lee BM. Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes. J Toxicol Environ Health A 2002;65:373–381.

    Article  CAS  PubMed  Google Scholar 

  26. Umeda M, Amagaya S, Ogihara Y. Effect of shosaikoto, daisaikoto and sannoshashinto (traditional Japanese and Chinese medicines) on experimental hyperlipidemia in rats. J Ethnopharmacol 1989;26:255–269.

    Article  CAS  PubMed  Google Scholar 

  27. Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, et al. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol 2002;64:1415–1424.

    Article  CAS  PubMed  Google Scholar 

  28. Liao JF, Hung WY, Chen CF. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur J Pharmacol 2003;464:141–146.

    Article  CAS  PubMed  Google Scholar 

  29. Zhou YP, Zhang JQ. Oral baicalin and liquid extract of licorice reduce sorbitol levels in red blood cell of diabetic rats. Chin Med J 1989;102:203–206.

    CAS  PubMed  Google Scholar 

  30. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alphaglucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 1998;61:1413–1415.

    Article  CAS  PubMed  Google Scholar 

  31. Shang YZ, Gong MY, Zhou XX, Li ST, Wang BY. Improving effects of SSF on memory deficits and pathological changes of neural and immunological systems in senescent mice. Acta Pharmacol Sin 2001;22:1078–1083.

    CAS  PubMed  Google Scholar 

  32. Shang Y, Cheng J, Qi J, Miao H. Scutellaria flavonoid reduced memory dysfunction and neuronal injury caused by permanent global ischemia in rats. Pharmacol Biochem Behav 2005;82:67–73.

    Article  CAS  PubMed  Google Scholar 

  33. Yamamoto H. In: Bajaj YPS, ed. Biotechnology in agriculture and forestry 15, Medicinal and aromatic plants III. 1991:398–411.

  34. Bochorakova H, Paulova H, Slanina J, Musil P, Taborska E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res 2003;17:640–644.

    Article  CAS  PubMed  Google Scholar 

  35. Yuan QJ, Zhang ZY, Hu J, Guo LP, Shao AJ, Huang LQ. Impacts of recent cultivation on genetic diversity pattern of a medicinal plant, Scutellaria baicalensis (Lamiaceae). BMC Genet 2010;11:29:1–13.

    CAS  Google Scholar 

  36. Chen P, Lin LZ, Harnly JM. Mass spect roscopic fingerprinting method for differentiation between Scutellaria lateriflora and the germander (Teucrium canadense and T. chamaedrys) species. J AOAC Int 2010;93:1148–1154.

    CAS  PubMed Central  PubMed  Google Scholar 

  37. World Health Organization. Scutellaria baicalensis in WHO monographs on selected medicinal plants. Geneva: World Health Organization; 1999:314–327.

    Google Scholar 

  38. Qian B, ed. Clinical effect of anticancer Chinese medicine Shanghai: Shanghai Translation Publishing House; 1987:6–7.

    Google Scholar 

  39. Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, et al. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine 2003;10:640–649.

    Article  CAS  PubMed  Google Scholar 

  40. Li ZP, Wei HQ. Chemical compounds of the genus Scutellaria. World Phytomed 1994;9:47.

    Google Scholar 

  41. Zhou ZH. New flavonoids glycosides from Scutellaria amoena. In: Yang CR ed. Advances in plant glycosides chemistry, Biology. Elsvier, Netherlands; 1997:305–310.

    Google Scholar 

  42. Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Blach-Olszewska Z, et al. Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS Neurol Disord Drug Targets 2011;10:184–191.

    Article  CAS  PubMed  Google Scholar 

  43. Mehendale S, Aung H, Wang CZ, Tong R, Foo A, Xie JT, et al. Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal sideeffects. J Pharm Pharmacol. 2007;59:1567–1572.

    Article  PubMed Central  PubMed  Google Scholar 

  44. Huen MS, Leung JW, Ng W, Lui WS, Chan MN, Wong JT, et al. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol 2003;66:125–132.

    Article  CAS  PubMed  Google Scholar 

  45. Irakli MN, Samanidou VF, Biliaderis CG, Papadoyannis IN. Simultaneous determination of phenolic acids and flavonoids in rice using solid-phase extraction and RP-HPLC with photodiode array detection. J Sep Sci 2012;35:1603–1611.

    Article  CAS  PubMed  Google Scholar 

  46. Makino T, Hishida A, Goda Y, Mizukami H. Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. J Nat Med 2008;62:294–299.

    Article  CAS  PubMed  Google Scholar 

  47. Ma SC, Du J, But PP, Deng XL, Zhang YW, Ooi VE, et al. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol 2002;79:205–211.

    Article  CAS  PubMed  Google Scholar 

  48. Ishimaru K, Nishikawa K, Omoto T, Asai I, Yoshihira K, Shimomura K. Two flavone 2′-glucosides from Scutellaria baicalensis. Phytochemistry 1995;40:279–281.

    Article  CAS  PubMed  Google Scholar 

  49. Ahmed A, Hussein MC, Torre DL, Jimeno ML, Rodríguez B, Bruno M, et al. A neo-clerodane diterpenoids from Scutellaria baicalensis. Phytochemistry 1996;43:835–837.

    Article  Google Scholar 

  50. Li HY, Hu J, Zhao S, Yuan ZY, Wan HJ, Lei F, et al. Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFalpha. J Biomed Biotechnol 2012;2012:267890.

    PubMed Central  PubMed  Google Scholar 

  51. Chen YC, Shen SC, Chen LG, Lee TJ, Yang LL. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 2001;61:1417–1427.

    Article  CAS  PubMed  Google Scholar 

  52. Shieh DE, Liu LT, Lin CC. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 2000;20:2861–2865.

    CAS  PubMed  Google Scholar 

  53. Kim YO, Leem K, Park J, Lee P, Ahn DK, Lee BC, et al. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J Ethnopharmacol 2001;77:183–188.

    Article  CAS  PubMed  Google Scholar 

  54. Zhang Z, Cui W, Li G, Yuan S, Xu D, Hoi MP, et al. Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCalpha and PI3K/AKT signaling pathways. J Agric Food Chem 2012;60:8171–8182.

    Article  CAS  PubMed  Google Scholar 

  55. Jeon SJ, Rhee SY, Seo JE, Bak HR, Lee SH, Ryu JH, et al. Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture. Neurosci Res 2011;69:214–222.

    Article  CAS  PubMed  Google Scholar 

  56. Lim JS, Yoo M, Kwon HJ, Kim H, Kwon YK. Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochem Biophys Res Commun 2010;402:42–47.

    Article  CAS  PubMed  Google Scholar 

  57. Zhang S, Ye J, Dong G. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. J Mol Neurosci 2010;40:311–320.

    Article  PubMed  Google Scholar 

  58. Yune TY, Lee JY, Cui CM, Kim HC, Oh TH. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem 2009;110:1276–1287.

    Article  CAS  PubMed  Google Scholar 

  59. Cho J, Lee HK. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biol Pharm Bull 2004;27:1561–1564.

    Article  CAS  PubMed  Google Scholar 

  60. Piao HZ, Jin SA, Chun HS, Lee JC, Kim WK. Neuroprotective effect of wogonin: potential roles of inflammatory cytokines. Arch Pharm Res 2004;27:930–936.

    Article  CAS  PubMed  Google Scholar 

  61. Tu XK, Yang WZ, Liang RS, Shi SS, Chen JP, Chen CM, et al. Effect of baicalin on matrix metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral ischemia in rats. Neurochem Res 2011;36:2022–2028.

    Article  CAS  PubMed  Google Scholar 

  62. Xue X, Qu XJ, Yang Y, Sheng XH, Cheng F, Jiang EN, et al. Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor kappaB p65 activation. Biochem Biophys Res Commun 2010;403:398–404.

    Article  CAS  PubMed  Google Scholar 

  63. Tu XK, Yang WZ, Shi SS, Chen Y, Wang CH, Chen CM, et al. Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia. Inflammation 2011;34:463–470.

    Article  CAS  PubMed  Google Scholar 

  64. Tu XK, Yang WZ, Shi SS, Wang CH, Chen CM. Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia. Neurochem Res 2009;34:1626–1634.

    Article  CAS  PubMed  Google Scholar 

  65. Cui L, Zhang X, Yang R, Liu L, Wang L, Li M, et al. Baicalein is neuroprotective in rat MCAo model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol Biochem Behav 2010;96:469–475.

    Article  CAS  PubMed  Google Scholar 

  66. Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, et al. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem 2010;112:1500–1512.

    Article  CAS  PubMed  Google Scholar 

  67. Xu YW, Sun L, Liang H, Sun GM. 12/15-Lipoxygenase inhibitor baicalein suppresses PPAR gamma expression and nuclear translocation induced by cerebral ischemia/ reperfusion. Brain Res 2010;1307:149–157.

    Article  CAS  PubMed  Google Scholar 

  68. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 2006;37:3014–3018.

    Article  PubMed  Google Scholar 

  69. Zhang Y, Wang X, Xu Z, Liu Z, Ni Q, Chu X, et al. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J Ethnopharmacol 2006;108:355–360.

    Article  CAS  PubMed  Google Scholar 

  70. Cao Y, Mao X, Sun C, Zheng P, Gao J, Wang X, et al. Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways. Brain Res Bull 2011;85:396–402.

    Article  CAS  PubMed  Google Scholar 

  71. Dai J, Chen L, Qiu YM, Li SQ, Xiong WH, Yin YH, et al. Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin’s neuroprotection against gerbil global ischemia/reperfusion injury. Brain Res Bull 2012;90C:1–9.

    Google Scholar 

  72. He XL, Wang YH, Gao M, Li XX, Zhang TT, Du GH. Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage. Brain Res 2009;1249:212–221.

    Article  CAS  PubMed  Google Scholar 

  73. Liu C, Wu J, Gu J, Xiong Z, Wang F, Wang J, et al. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav 2007;86:423–430.

    Article  CAS  PubMed  Google Scholar 

  74. Lee JH, Lee SR. The effect of baicalein on hippocampal neuronal damage and metalloproteinase activity following transient global cerebral ischaemia. Phytother Res 2012;26:1614–1619.

    Article  CAS  PubMed  Google Scholar 

  75. Lee H, Kim YO, Kim H, Kim SY, Noh HS, Kang SS, et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 2003;17:1943–1944.

    CAS  PubMed  Google Scholar 

  76. Cheng O, Li Z, Han Y, Jiang Q, Yan Y, Cheng K. Baicalin improved the spatial learning ability of global ischemia/ reperfusion rats by reducing hippocampal apoptosis. Brain Res 2012;1470:111–118.

    Article  CAS  PubMed  Google Scholar 

  77. Tai MC, Tsang SY, Chang LY, Xue H. Therapeutic potential of wogonin: a naturally occurring flavonoid. CNS Drug Rev 2005;11:141–150.

    Article  CAS  PubMed  Google Scholar 

  78. Ma X, Xie KP, Shang F, Huo HN, Wang LM, Xie MJ. Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor alpha expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane. Physiol Acta (Chin) 2012;64:207–212.

    CAS  Google Scholar 

  79. Chung H, Jung YM, Shin DH, Lee JY, Oh MY, Kim HJ, et al. Anticancer effects of wogonin in both estrogen receptorpositive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int J Cancer 2008;122:816–822.

    Article  CAS  PubMed  Google Scholar 

  80. Kim EJ, Kang D, Han J. Baicalein and wogonin are activators of rat TREK-2 two-pore domain KP+ channel. Acta Physiol (Oxf) 2011;202:185–192.

    Article  CAS  Google Scholar 

  81. Po LS, Chen ZY, Tsang DS, Leung LK. Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells. Cancer Lett 2002;187:33–40.

    Article  CAS  PubMed  Google Scholar 

  82. Kim SJ, Lee SM. Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Toxicol Appl Pharmacol 2012;258:43–50.

    Article  CAS  PubMed  Google Scholar 

  83. Lim HA, Lee EK, Kim JM, Park MH, Kim DH, Choi YJ, et al. PPARgamma activation by baicalin suppresses NF-kappaB-mediated inflammation in aged rat kidney. Biogerontology 2012;13:133–145.

    Article  CAS  PubMed  Google Scholar 

  84. Zhang Q Sun W, Han Z, Zhong Y, Wang B. Scutellaria baicalensis Georgi against cerebral ischemia and oxidative injury. Asian J Tradit Med 2009;4:26–35.

    Google Scholar 

  85. Cho J, Lee HK. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur J Pharmacol 2004;485:105–110.

    Article  CAS  PubMed  Google Scholar 

  86. Li FQ, Wang T, Pei Z, Liu B, Hong JS. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. J Neural Transm 2005;112:331–347.

    Article  CAS  PubMed  Google Scholar 

  87. Chung CP, Park JB, Bae KH. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Planta Med 1995;61:150–153.

    Article  CAS  PubMed  Google Scholar 

  88. Li H, Wang H, Chen JH, Wang LH, Zhang HS, Fan Y. Determination of amino acid neurotransmitters in cerebral cortex of rats administered with baicalin prior to cerebral ischemia by capillary electrophoresis-laser-induced fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 2003;788:93–101.

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, 130-701, Korea

    Bhakta Prasad Gaire & Hocheol Kim

  2. Department of Carcliology and Neurology, Hospital of Oriental Medicine, Kyung Hee University, Seoul, Korea

    Sang-Kwan Moon

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  1. Bhakta Prasad Gaire
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Gaire, B.P., Moon, SK. & Kim, H. Scutellaria baicalensis in stroke management: Nature’s blessing in traditional Eastern medicine. Chin. J. Integr. Med. 20, 712–720 (2014). https://doi.org/10.1007/s11655-014-1347-9

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