Skip to main content

Advertisement

SpringerLink
Log in

Treatment of neuropathic pain with plant medicines

  • Feature Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Neuropathic pain is a common and very prevalent disorder affecting the citizens of both developed and developing countries. The approved and licensed drugs for neuropathic pain are reported to have associated side effects. Traditional plant treatments have been used throughout the world for the treatment of neuropathic pain. Among the many medications and other alternative medicines, several herbs are known to cure and control neuropathic pain with no side effects. The present paper discusses the plants with neuropathic pain and related beneficial effects originating from different parts of world that are of current interest.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Muthraman A, Singh N. Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects. Complement Aalternat Med 2011;11:24.

    Article  Google Scholar 

  2. Siniscalco D, Rossi F, Maione S. Molecular approaches for neuropathic pain treatment. Curr Med Chem 2007; 14:1783–1787.

    Article  PubMed  CAS  Google Scholar 

  3. Choi SZ, Son Mi-Won. A novel botanical drug for the treatment of diabetic neuropathy. Arch Pharm Res 2011;34:865–867.

    Article  PubMed  CAS  Google Scholar 

  4. Muthuraman A, Singh N. Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transaction-induced painful neuropthy in rats. J Nat Med 2011;65:282–292.

    Article  PubMed  Google Scholar 

  5. Muthuraman A, Singh N, Jaggi AS. Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and antioxidative activity. Food Chem Toxicol 2011;49:2557–2563.

    Article  PubMed  CAS  Google Scholar 

  6. Bisht D, Chanotiya C, Mishra D, Pandey K. Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger. Nat Prod Res 2011;25:1993–1998.

    Article  PubMed  CAS  Google Scholar 

  7. Muthuraman A, Singh N. Attenuating effect of hydroalcoholic extract of Acorus calamus in Vincristine-induced painful neuropathy in rats. J Nat Med 2011;65:480–487.

    Article  PubMed  CAS  Google Scholar 

  8. Watcho P, Stavniichuk R, Ribnicky DM, Raskin Ilya, Obrosova IG. High-fat diet induced neuropathy of prediabetes and obesity: effect of pmi-5011, an ethanolic extract of Artemiesia dracunculus L. Mediators Inflamm 2010:268547. Epub 2010 Apr 8.

  9. Obolskiy D, Pischel I, B. Feistel, N. Glotov, M. Heinrich. Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology and safety. J Agric Food Chem 2011;59:11367–11384.

    Article  PubMed  CAS  Google Scholar 

  10. Xu HM, Arita H, Hayashida M, Zhang L, Sekiyama H, Hanaoka K. Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. J Ethnopharmacol 2006;103:392–397.

    Article  PubMed  Google Scholar 

  11. Yue H, Pi Z, Song F, Liu Z, Cai Z, Liu S. Studies on the aconitine type alkaloids in the roots of Aconitum charmichaeli Debs by HPLC/EIMS/MS(n). Talanta 2009;77:1800–1807.

    Article  PubMed  CAS  Google Scholar 

  12. Shim S, Lee S, Kim J, Son K, Kang S. Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli. Arch Pharm Res 2005;28:1239–1243.

    Article  PubMed  CAS  Google Scholar 

  13. Karanian DA, Bahr BA. Cannabinoid drugs and enhancement of endocannabinoid responses: strategies for a wide array of disease states. Curr Mol Med 2007;6:677–684.

    Article  Google Scholar 

  14. Costa B, Trovato AE, Comelli F, Giagnoni G, Colleoni M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur J Pharmacol 2007;556:75–83.

    Article  PubMed  CAS  Google Scholar 

  15. Comelli F, Giagnoni G, Bettoni, Isabella, Colleoni M, Costa B. Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved. Phyotherapy Research 2008;22:1017–1024.

    Article  Google Scholar 

  16. Vani T, Rajani M, Sarkar S, Shishoo CJ. Antioxidant property of the Ayurvedic formulation Triphala and its constituents. Int J Pharmacol 2007;35:313–317.

    Google Scholar 

  17. Tiwari V, KUhad A, Chopra K. Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. Phytother Res 2011;25:1527–1536.

    Article  PubMed  Google Scholar 

  18. Baliga MS, Dsouza JJ. Amla (emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prevent 2011;20:225–239.

    Article  CAS  Google Scholar 

  19. Kim YS, Park HJ, Kim TK, Moon DE, Lee HJ. The effects of Ginkgo Biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. Pain Mechanisms 2009;108:1958–1963.

    Google Scholar 

  20. EGb 761: ginkgo biloba extract, Ginkor. Drugs R D 2003;4:188–193.

  21. Kanter M. Effects of Nigella sativa and its major constituent thymoquinone on sciatic nerves in experimental diabetic neuropath. Neurochem Res 2008;33:87–96.

    Article  PubMed  CAS  Google Scholar 

  22. Hess SC, Monache FD. Divergioic acid, a triterpene from Vochysia divergens. J Brazilian Chem Soc 1999;10:104–106.

    Article  CAS  Google Scholar 

  23. Beirith A, Santos AR, Calixto JB, Hess SC, Messana I, Ferrari F, et al. Study of the antinociceptive action of the etha-nolic extract and the triterpene 24-hydroxytormentic acid isolated from Ocotea suaveolens (Meissn) Hassler. Planta Med 1999;65:50–55.

    Article  PubMed  CAS  Google Scholar 

  24. Bortalanza LB, Ferreira J, Hess SC, Monache FD, Yunes RA, Calixto JB. Anti-allodynic action of the tormentic acid, a triterpene isolated from plant against neuropathic and inflammatory persistent pain in mice. Eur J Pharmacol 2002;453:203–208.

    Article  PubMed  CAS  Google Scholar 

  25. Bahnot A, Shri R. A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice. Pharmacognosy Res 2010;2:374–384.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA, 90089-9121, USA

    Garima Garg & James D. Adams

Authors
  1. Garima Garg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James D. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James D. Adams.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garg, G., Adams, J.D. Treatment of neuropathic pain with plant medicines. Chin. J. Integr. Med. 18, 565–570 (2012). https://doi.org/10.1007/s11655-012-1188-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11655-012-1188-6

Keywords

Search

Navigation