Abstract
Objective
To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis (CSG) with the Pi-deficiency syndrome (PDS) and those of the non-Pi-deficiency syndrome (non-PDS), i.e. patients of CSG with Pi (脾)-Wei (胃) dampnese-heat syndrome and healthy persons.
Methods
With the BRB-Array Tools software package, original data collection and bioinformatic: analysis of gene arrays were conducted in 6 CSG patients of PDS (CSG-PDS), 6 CSG patients of non-PDS (CSG-nPDS), and 6 healthy volunteers (Normal).
Results
Compared with non-PDS, the gene expressions: in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly.
Conclusions
The two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.
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Supported by the National Natural Science Foundation of China (No. 90209004) and E-Institute Construction Plan Project of Shanghai Municipal Education Committee (No. E03008)
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Chen, Yl., Chen, Ww., Wang, Yf. et al. Bioinformatics research on chronic superficial gastritis of Pi-deficiency syndrome by gene arrays. Chin. J. Integr. Med. 15, 341–346 (2009). https://doi.org/10.1007/s11655-009-0341-3
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DOI: https://doi.org/10.1007/s11655-009-0341-3